Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC40651 Oxyphenbutazone
羟布宗
An NSAID
GC40645 Actarit
阿克他利,4-Acetylaminophenylacetic acid; MS-932
An anti-inflammatory agent
GC40632 CMS121 A substituted quinoline with diverse biological activities
GC40616 Des-4-fluorobenzyl Mosapride
莫沙必利脱氟苄基杂质
A metabolite of mosapride
GC40611 Prostaglandin E3
PGE3
Decreases IOP in rabbits
GC40610 Prostaglandin D3
PGD3
An inhibitor of platelet aggregation
GC40595 (S)-AM1241
(-)AM1241
A CB₂ receptor agonist
GC40594 (R)-AM1241
(+)AM1241
A CB₂ receptor agonist and inverse agonist
GC40587 8,12-iso-iPF2α-VI
8,12-iso-Isoprostane-F2α-VI, 12-iso-5,6E,14Z-PGF2α, 125,6E,14ZProstaglandin F2α
An isoprostane used as a biomarker for oxidative stress
GC40572 7-keto Cholesterol
胆甾-3-羟基-5-烯-7-酮,SC-4722, 7-酮胆固醇
7-keto Cholesterol是一种与血管疾病相关的主要氧甾醇，广泛存在于动脉粥样硬化斑块中，具有比胆固醇更强的致动脉粥样硬化作用。
GC40571 24(S),25-epoxy Cholesterol
(24S)-24,25-环氧胆固醇,24(S)-24,25-EC
An oxysterol
GC40569 Cyclopenin
(-)-Cyclopenine
An AChE inhibitor
GC40565 Feprazone
非普拉宗,DA2370; Prenazone; Zepelin
A COX-2 inhibitor
GC40510 4-Methylumbelliferyl-α-D-Galactopyranoside
4-甲基伞形酮-α-D-吡喃半乳糖苷; 4MU-α-Gal
A fluorogenic substrate of α-galactosidase
GC40487 3-hydroxy Undecanoic Acid
3-羟基十一烷酸
A hydroxy fatty acid
GC40479 6-Aminophenanthridine
6AP
An antiprion agent
GC40476 Allethrin
丙烯菊酯
A pyrethroid insecticide
GC40473 2-hydroxy Lignoceric Acid
2-羟基二十四烷酸
An α-hydroxy very long chain fatty acid
GC40467 (±)11-HETE
(±)11-Hydroxyeicosatetraenoic Acid
A non-enzymatically derived oxylipin
GC40401 Prostaglandin F2α Alcohol methyl ether
AGN 191129, PGF2αOMe
A PGF_2α analog
GC40392 17-phenyl trinor Prostaglandin F2α methyl ester
比马前列素酸甲基酯
A lipophilic analog of 17-phenyl trinor PGF_2α
GC40352 Cafestol
咖啡醇
Cafestol是咖啡中主要活性成分之一，是一种咖啡特异性二萜类化合物，具有ERK2抑制活性。
GC40287 Octyl-α-hydroxyglutarate
Octyl2-HG
A cell-permeable form of 2-HG
GC40286 (E,Z)-2-propyl-2-Pentenoic Acid
2-丙基-2-戊烯酸
A valproic acid metabolite
GC40262 α-Humulene
ALPHA-律草烯,Humulene; α-Caryophyllene
A sesquiterpene with diverse biological activities
GC34944 β-CGRP, human TFA
Human β-CGRP TFA; CGRP-II (Human) (TFA)
β-CGRP,humanTFA是一种降钙素肽，通过降钙素受体样受体CRLR与RAMP的复合物起作用，在细胞体系中，对CRLR/RAMP1和CRLR/RAMP2的IC50值分别为1nM和300nM。
GC34842 Toloxatone
托洛沙酮; MD 69276

An inhibitor of MAO-A
GC34828 Tat-NR2B9c TFA
Tat-NR2Bct TFA; NA-1 TFA
Tat-NR2B9c(TFA)是由20个氨基酸组成的多肽，为PSD-95的抑制剂，对PSD-95d2和PSD-95d1的EC50值分别为6.7nM和670nM。Tat-NR2B9c同时可降低NMDA诱导的p38的活化，具有神经保护作用。
GC34753 Radiprodil
RGH-896

An NMDA receptor antagonist
GC34684 Neurokinin B TFA
神经激肽 B 三氟乙酸盐
NeurokininBTFA属于速激肽家族。Neurokinin结合到一系列G蛋白偶联受体(GPCR)-包括神经激肽受体1(NK1R)，NK2R和NK3R，且介导其生物学作用。
GC34683 Neurokinin A(4-10) TFA NeurokininA(4-10)TFA是速激肽NK2受体激动剂。
GC34638 JNJ-61432059 JNJ-61432059是具有口服活性的、选择性的AMPAR的负向调节剂，其对GluA1/γ-8的pIC50值为9.7。在老鼠的海马体中显示出具有时间和剂量依赖性的AMPA受体占用情况，在角膜点燃癫痫动物模型中显示出较强的保护作用。
GC34575 Eplivanserin mixture
SR-46349 (mixture)
Eplivanserinmixture是一种选择性的血清素再摄取抑制剂，是5-HT2A受体的拮抗剂。化合物信息来自专利WO2005/002578A1。
GC34559 DOV-216,303 Free Base
1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷
DOV-216,303(FreeBase)是有效的5-羟色胺、去甲肾上腺素、多巴胺再摄取的三重抑制剂，其对hSERT、hNET和hDAT的IC50值分别为14nM，20nM和78nM。在嗅球切除大鼠模型中，可增加前额皮质中单胺的释放及具有抗抑郁的作用。
GC34494 Bifenazate
联苯肼酯
An acaricide
GC34477 AT-1002 TFA AT-1002TFA是一种6聚体合成肽，是一种紧密连接(junction)的调节剂和吸收增强剂。
GC19514 1-Methyl-L-tryptophan
相思子碱
An IDO inhibitor
GC19499 A-381393 A-381393 是一种有效的、选择性的脑穿透多巴胺 D4 受体拮抗剂，对人多巴胺 D4.4、D4.2 和 D4.7 受体的 Kis 分别为 1.5、1.9 和 1.6 nM，比选择性高 2700 倍以上D1、D2、D3 和 D5 多巴胺受体。
GC40237 Ramelteon-d5
TAK-375-d5
An internal standard for the quantification of ramelteon
GC40227 Indomethacin-d4
吲哚美辛-D4; Indometacin-d4
An internal standard for the quantification of indomethacin
GC40225 Olanzapine-d8
奥氮平-d8
An internal standard for the quantification of olanzapine
GC40196 Levetiracetam-d6
左乙拉西坦杂质-d6,UCB L059-d6
An internal standard for the quantification of levetiracetam
GC40191 Ibuprofen Carboxylic Acid
羧基布洛芬
A major metabolite of ibuprofen
GC40190 Febuxostat Acyl Glucuronide
非布司他杂质
A metabolite of febuxostat
GC40184 Probenecid-d14
丙磺舒 d14
An internal standard for the quantification of probenecid
GC40176 1-Stearoyl-rac-glycerol
单硬脂酸甘油酯
A monoacylglycerol
GC40161 ACTH (4-10) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
Adrenocorticotropic Hormone (4-10), Corticotropin (4-10)
An endogenous peptide fragment of ACTH
GC40159 PAR1 (1-6) (mouse, rat) (trifluoroacetate salt)
H-Ser-Phe-Phe-Leu-Arg-Asn, PAR1-AP, Proteinase-Activated Receptor 1, SFFLRN, TRAP, Thrombin Receptor Activating Peptide
A peptide agonist of PAR1
GC40145 (S)-Laudanosine
(+)-Laudanosine, L-Laudanosine, L-(+)-Laudanosine, NSC 35045
The (S) enantiomer of laudanosine
GC40143 Dihydrotetrabenazine
反式(2,3)-二氢丁苯那嗪
An active metabolite of tetrabenazine