Membrane Transporter/Ion Channel(跨膜转运)

Cat.No. 产品名称 Information

GC30986 Nicardipine (YC-93)

尼卡地平; YC-93 free base

Nicardipine is a potent calcium channel blockader with marked vasodilator action.

GC30984 XEN907 XEN907是一种新型的螺羟吲哚类NaV1.7阻断剂,抑制hNaV1.7,IC50为3nM。

GC30983 alpha-Asarone (α-Asarone)

α-细辛脑; α-Asarone; trans-Asarone

An inhibitor of HMG-CoA reductase and CYP450 isoforms

GC30977 Ca2+ channel agonist 1 Ca2+channelagonist1是一种N-型钙离子通道(N-typeCa2+channel)激动剂和Cdk2的抑制剂，EC50分别为14.23μM和3.34μM，对运动神经终端功能障碍有潜在疗效。

GC30973 Mephenesin

甲酚甘油醚

Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.

GC30961 Mirogabalin besylate (DS 5565 besylate)

10928苯磺酸盐,DS 5565 besylate

A calcium channel blocker

GC30957 Propoxycaine hydrochloride

盐酸丙氧卡因；丙氧卡因盐酸盐

Propoxycaine盐酸盐是一种局部麻醉剂,结合并抑制电压门控钠通道,抑制脉冲起始和传导所需的离子通量,从而导致感觉的丢失。

GC30951 MDL 105519

3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸

MDL105519是有效和选择性的甘氨酸与NMDA受体结合的拮抗剂。

GC30950 TTA-Q6 TTA-Q6是T型Ca2+通道的选择性拮抗剂，可用于神经学研究。

GC30946 Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid)

丙环定盐酸盐; Tricyclamol hydrochloride; (±)-Procyclidine hydrochloride

A muscarinic acetylcholine receptor antagonist

GC30943 6,2'-Dihydroxyflavone

6,2-二羟基黄酮

6,2'-Dihydroxyflavone是一个新型的GABAA受体拮抗剂。

GC30933 (+)-Kavain

醉椒素

A kavalactone with diverse biological activities

GC30930 DAA-1106

N-(2,5-二甲氧基苄基)-N-(5-氟-2-苯氧基苯基)乙酰胺

A TSPO agonist

GC30927 Acevaltrate

乙酰缬草三酯

Acevaltrate, an active component derived from the herbal plant Valeriana jatamansi Jones, is strikingly potent to induce GBM cell apoptosis. Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50 of 22.8 μM and 42.3 μM, respectively.

GC30917 AM-2099 AM-2099是电压门控钠通道Nav1.7的有效，选择性的抑制剂，对人类Nav1.7的IC50值为0.16μM。

GC30914 Butamben (Butyl 4-aminobenzoate)

4-氨基苯甲酸丁酯,Butyl 4-aminobenzoate

Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.

GC30911 Apimostinel (NRX-1074)

NRX-1074; AGN-241660

Apimostinel (NRX-1074) (NRX-1074; AGN-241660) 是一种具有口服活性的 NMDA 受体部分激动剂。

GC30910 Eucalyptol (1,8-Cineole)

NSC 6171

Eucalyptol是5-HT3受体,钾通道,TNF-α和IL-1β的抑制剂。

GC30898 6-Methylflavone

6-甲基黄酮

6-methylflavone是α1β2γ2L和α1β2GABAA受体的激活剂。

GC30893 TRPM8 Antagonist TRPM8 antagonist 2 (TRPM8 Antagonist) is a potent and selective antagonist of TRPM8 with IC50 of 0.2 nM that can be used for the pharmacological treatment of neuropathic pain syndromes.

GC30891 Almitrine mesylate (Almitrine bismesylate)

甲磺酸阿米三嗪,Almitrine bismesylate; Almitrine bismethanesulfonate; Almitrine dimesylate

Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM.

GC30889 (-)-Securinine

一叶秋碱

An alkaloid

GC30873 Mirogabalin (DS5565)

米洛巴林,DS5565

A calcium channel blocker

GC30866 Anabasine ((S)-Anabasine)

(+)-假木贼碱; (S)-Anabasine; (+)-Anabasine

Anabasine ((S)-Anabasine) ((S)-Anabasine ((S)-Anabasine)) 是一种生物碱，在烟草 (Nicotiana) 中是一种微量成分。

GC30865 TPA 023 TPA023是GABAAα2/α3的选择性的激动剂，Ki值为0.19-0.41nM。

GC30862 L-Cycloserine ((S)-4-Amino-3-isoxazolidone)

环丝氨酸,(S)-Cycloserine; (S)-4-Amino-3-isoxazolidone

An inhibitor of sphingolipid synthesis and aminotransferases

GC30860 Neu2000

Salfaprodil free base; Neu2000

Neu2000 (Salfaprodil free base) 是 N-甲基-D-天冬氨酸 (NMDA) 的 NR2B 选择性和非竞争性拮抗剂。

GC30852 Org-26576 Org26576是AMPA受体的正变构调节剂。

GC30850 GV-58

(2R)-2-[[6-[[(5-甲基噻吩-2-基)甲基]氨基]-9-丙基-9H-嘌呤-2-基]氨基]丁烷-1-醇

GV-58 is a novel, selective N-type and P/Q-type Ca2+ channels agonist with IC50s of 7.21 μM and 8.81 μM, respectively.

GC30847 IC87201 An inhibitor of the nNOS-PSD-95 protein-protein interaction

GC30844 Afloqualone

氟喹酮; HQ-495

An Analytical Reference Standard

GC30839 Traxoprodil

曲索罗地

An antagonist of NR2B subunit-containing NMDA receptors

GC30837 A-1165442 A-1165442是有效，竞争性，有口服活性的TRPV1拮抗剂，对人TRPV1的IC50值为9nM。

GC30835 Rislenemdaz (MK-0657)

MK-0657; CERC-301

Rislenemdaz (MK-0657) (CERC-301) 是一种口服生物可利用的选择性 N-甲基-D-天冬氨酸 (NMDA) 受体亚基 2B (GluN2B) 拮抗剂，其 Ki 和 IC 50 分别为 8.1 nM 和 3.6 nM。

GC30827 Pipequaline (PK-8165)

哌夸林,PK-8165

A partial agonist of central benzodiazepine receptors

GC30818 ZL006 An nNOS/PSD-95 interaction inhibitor

GC30815 Synaptamide (Dehydroepiandrosteron(DHEA))

DEA, DHEA, Synaptamide

An endocannabinoid found in brain and retina

GC30813 Raxatrigine hydrochloride (GSK-1014802 hydrochloride)

GSK-1014802 hydrochloride; CNV1014802 hydrochloride

An inhibitor of voltage-gated sodium channels

GC30807 ZSET1446 (ST-101)

ST-101

ZSET1446 (ST-101) 是一种新型认知增强剂，可显着改善各种类型的阿尔茨海默病 (AD) 模型中的学习缺陷。

GC30805 PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine)

N-(p-Methylphenylsulfonyl)phenoxazine

PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine) 是一种有效的选择性 P2X4 拮抗剂，对人 P2X4 的 IC50 为 1.38 μM。

GC30799 HC-070 HC-070是一种瞬时受体电位通道蛋白4/5(TRPC4/TRPC5)拮抗剂，在细胞中，对hTRPC5和hTRPC4的IC50值分别为9.3nM和46nM。

GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate)

谷氨酸单钠盐

L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.