Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. 产品名称 Information
GC13942 SirReal2
乙酰胺,2-[(4,6-二甲基-2-嘧啶基)硫]-N-[5-(1-萘甲基)-2-噻唑]-
A selective SIRT2 inhibitor
GC17828 BI-847325 A selective dual MEK/Aurora kinase inhibitor
GC10341 Peficitinb (ASP015K, JNJ-54781532)
培菲替尼,ASP015K; JNJ-54781532
A JAK inhibitor
GC11031 PX-478 2HCl PX-478是一种选择性抑制剂，可以抑制常规和低氧诱导的HIF-1α水平。
GC16875 FLLL32
(2E,2'E)-1,1'-环己基亚基二[3-(3,4-二甲氧基苯基)-2-丙烯-1-酮]
An inhibitor of JAK2/STAT3 signaling
GC15789 GSK2801 A probe for BAZ2A/B bromodomains
GC16914 MN 64 A TNKS inhibitor
GC11652 CHZ868 CHZ868 是一种 II 型 JAK2 抑制剂，在 EPOR JAK2 WT Ba/F3 细胞中的 IC50 为 0.17 μM。
GC12976 Suberohydroxamic Acid
软木肟酸,Suberohydroxamic acid; SBHA
HDAC inhibitor
GC11873 2,4-Pyridinedicarboxylic Acid
2,4-吡啶二羧酸
An inhibitor of 2-oxoglutarate-dependent enzymes
GC17704 Triacetyl Resveratrol
三乙酰基白藜芦醇
A resveratrol derivative with diverse biological activities
GC10979 PFI 4 A chemical probe for BRPF1
GC13442 Sanguinarine chloride
氯化血根碱; Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride
A natural alkaloid with anti-inflammatory and anti-oxidant properties
GC11249 2-hexyl-4-Pentynoic Acid
2-正己基-4-戊炔酸,(±)-2-Hexyl-4-pentynoic acid
An HDAC inhibitor
GC12822 BML-210(CAY10433)
NphenylN'(2Aminophenyl)hexamethylenediamide, CAY10433
A potent, synthetic HDAC inhibitor
GC14367 UF 010 A class I HDAC inhibitor
GC14938 PF-03394197(Oclacitinib)
奥拉替尼
A JAK family kinase inhibitor
GC12821 Oltipraz
奥替普拉; RP 35972; NSC 347901
A Nrf2 and CAR activator
GC12074 BG45 A selective HDAC3 inhibitor
GC10417 ACY-241
西他司他,Citarinostat
An HDAC6 inhibitor
GC10770 Decernotinib(VX-509)
迪西替尼
A selective JAK3 inhibitor
GC16042 Chidamide
西达本胺,Chidamide impurity
An HDAC inhibitor
GC12005 C7280948 A PRMT1 inhibitor
GC16299 BET bromodomain inhibitor
BET抑制剂,CPI-0610; CPI0610; CPI 0610
BET 溴结构域抑制剂是从专利 WO/2015/153871A2 化合物实施例 11 中提取的一种有效的 BET 抑制剂。
GC11578 GSK2879552 An LSD1 inhibitor
GC10046 Molidustat (BAY85-3934)
BAY 85-3934
A pan-HIF-PH inhibitor
GC11641 Boc-Lys(Ac)-AMC A fluorogenic HDAC substrate
GC12997 GSK J4 free base
N-[2-(2-吡啶基)-6-(1,2,4,5-四氢-3H-3-苯并氮杂卓-3-基)-4-嘧啶基]-BETA-丙氨酸乙酯
GSK J4 free base 是 H3K27me3/me2-去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 的有效双重抑制剂，IC50 分别为 8.6 和 6.6 μM。 GSK J4 游离碱抑制 LPS 诱导的 TNF-α；在人原代巨噬细胞中产生，IC50 为 9 μM. GSK J4 是 GSK-J1 的细胞渗透性前药。 GSK J4 free base 诱导内质网应激相关的细胞凋亡。
GC14857 LFM-A13 A BTK inhibitor
GC16638 FG2216
IOX3; YM311
An inhibitor of HIF-PH2
GC11414 GSK503 A potent, selective EZH2 inhibitor
GC13541 G007-LK
Tankyrase 1/2 Inhibitor VI
A TNKS1/2 inhibitor
GC15049 MCB-613
4-乙基-2,6-双(吡啶-3-基亚甲基)环己酮
A small molecule stimulator of SRCs
GC15302 EPZ015666
GSK3235025
A bioavailable PRMT5 inhibitor
GC12484 BRD73954 A dual inhibitor of HDAC6 and HDAC8
GC15368 GSK-LSD1 2HCl 不可逆的、选择性的 LSD1 抑制剂
GC12498 Sephin1
(E/Z)-Sephin1; (E/Z)-IFB-088
A selective inhibitor of the phosphatase regulatory subunit PPP1R15A
GC14763 WDR5 0103
WD-Repeat Protein 5-0103
An inhibitor of WDR5 peptide binding
GC15652 UNC 2400 UNC 2400 与 UNC1999 非常相似，作为细胞研究的阴性对照，其效力比 UNC1999 低 1,000 倍以上。
GC16015 A 366 A potent inhibitor of G9a
GC13474 Garcinol
山竹子素

Garcinol是组蛋白乙酰转移酶p300和PCAF的非特异性抑制剂，IC₅₀分别为7μM和5μM。
GC15836 IWP 12
Inhibitor of Wnt Production-12
A PORCN inhibitor
GC10319 TC-E 5002
N-(9-环丙基-1-氧代壬基)-N-羟基-Β-丙氨酸
A KDM2/7 inhibitor
GC14655 OXF BD 02 OXF BD 02 是 BRD4(1)（BRD4 的第一个溴结构域）的选择性抑制剂，IC50 值为 382 nM。
GC10727 Ischemin sodium salt CBP bromodomain inhibitor
GC12440 GSK 5959 An inhibitor of the BRPF1 bromodomain
GC15175 BAZ2-ICR A BAZ2A/B bromodomain inhibitor
GC17126 EX-527 R-enantiomer
(R)-EX-527
EX-527 R-对映异构体 ((R)-EX-527) 是 Selisstat 的 R-对映异构体。 Selisistat (EX-527) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 98 nM。
GC13417 EX-527 S-enantiomer
(1S)-6-氯-2,3,4,9-四氢-1H-咔唑-1-甲酰胺,(S)-EX-527
EX-527 S-对映异构体 ((S)-EX-527) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 98 nM。
GC17482 OF-1 A bromodomain probe for BRPF proteins