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Home >> Signaling Pathways >> Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. 产品名称 Information
  2. GC14168 UMB-32 An inhibitor of BRD4, TAF1, and TAF1L bromodomains
  3. GC17005 4-iodo-SAHA

    ISAHA

     A potent SAHA analog
  4. GC16763 NI-57 A BRPF bromodomain inhibitor
  5. GC14240 MS049 (hydrochloride) A selective, dual PRMT4/PRMT6 inhibitor
  6. GC13025 GSK6853 A selective chemical probe for the bromodomain of BRPF1
  7. GC16900 PRL-3 Inhibitor

    BR-1,P0108,Phosphatase of Regenerating Liver 3 Inhibitor,PTP4A3 Inhibitor

     An inhibitor of PTP4A3
  8. GC13668 Phthalazinone pyrazole Potent, selective inhibitor of Aurora kinase A
  9. GC12458 N-Oxalylglycine

    N-草酰甘氨酸,NOG

     An inhibitor of JMJD2 histone demethylases
  10. GC12082 Cantharidic Acid (sodium salt) A protein phosphatase inhibitor
  11. GC13062 JGB1741

    ILS-JGB-1741

     A SIRT1 inhibitor
  12. GC13534 Lysine-specific Demethylase Inhibitor (1C)

    KDM1 Inhibitor I|LSD1 Inhibitor

     lysine-specific demethylase Inhibitor
  13. GC15120 PTP Inhibitor I

    2-溴-4'-羟基苯乙酮,α-Bromo-4-hydroxyacetophenone|2-Bromo-4'-hydroxyacetophenone|4-Hydroxyphenacyl bromide|Protein Tyrosine Phosphatase Inhibitor I|SHP-1 Inhibitor II

     A SHP-1(ΔSH2) and PTP1B inhibitor
  14. GC15301 PBIT

    2-​p-​tolyl-1,​2-​Benzisothiazolin-​3-​one

     An inhibitor of JARID1 family demethylases
  15. GC17922 4'-bromo-Resveratrol

    5-[(E)-2-(4-溴苯基)乙烯基]间苯二酚,4′‐BR

     A potent inhibitor of SIRT1 and SIRT3
  16. GC15804 PTP Inhibitor II

    alpha-溴-4-甲氧基苯乙酮,α-Bromo-4’-methoxyacetophenone|ω-Bromo-4’-methoxyacetophenone|4-(Bromoacetyl)anisole|4-Methoxyphenacyl bromide|NSC 129010|Protein Tyrosine Phosphatase Inhibitor II

     A SHP-1(ΔSH2) inhibitor
  17. GC16432 MS023 (hydrochloride) An inhibitor of type I PRMTs
  18. GC13014 AZD 5153 A BRD4 inhibitor
  19. GC14362 Lin28 1632 An inhibitor of the Lin28/let-7 interaction
  20. GC10898 5-(N,N-dimethyl)-Amiloride (hydrochloride)

    DMA,L-591,605,MK-685

     An inhibitor of Na+/H+ exchangers
  21. GC10226 Butyrolactone 3

    丁内酯 3; MB-3

     A HAT inhibitor
  22. GC14428 CPTH2 (hydrochloride) A HAT inhibitor
  23. GC14282 3-acetyl-11-keto-β-Boswellic Acid

    11-羰基-Β-乙酰乳香酸,3-O-acetyl-11-keto-β-Boswellic acid,AKBA

     A selective 5-LO inhibitor
  24. GC16298 CPI-1205 EZH2抑制剂
  25. GC14597 ITSA-1 (ITSA1)

    ITSA-1 是一种组蛋白去乙酰化酶（HDAC）激活剂，能够抑制HDAC抑制剂TSA对HDAC的抑制，但不抑制其他HDAC抑制剂。
  26. GC14103 NSC228155 An EGFR activator and inhibitor of KID-KIX interactions
  27. GC10774 CPI-455

    6-异丙基-7-氧代-5-苯基-4,7-二氢吡唑并[1,5-A]嘧啶-3-腈

     A KDM5 inhibitor
  28. GC17023 HLCL-61 A PRMT5 inhibitor
  29. GC10382 CPI-637 An inhibitor of CBP/EP300 bromodomains
  30. GC15152 PF-CBP1 An inhibitor of the CBP and p300 bromodomains
  31. GC16726 BI-7273 A potent BRD9 bromodomain inhibitor
  32. GC16817 BI-9564 A selective BRD9/7 bromodomain inhibitor
  33. GC10099 MS023

    N1-甲基-N1-[[4-[4-(异丙氧基)苯基]-1H-吡咯-3-基]甲基]-1,2-乙二胺

     MS023 是 I 型蛋白精氨酸甲基转移酶 (PRMT) 的有效、选择性和细胞活性抑制剂。
  34. GC14585 GSK591

    EPZ015866; GSK3203591

     A chemical probe for PRMT5
  35. GC12588 I-BRD9 A BRD9 bromodomain inhibitor
  36. GC16397 OICR-9429 A probe for WDR5
  37. GC16725 AZ6102

    REL-2-[4-[6-[(3R,5S)-3,5-二甲基-1-哌嗪基]-4-甲基-3-吡啶基]苯基]-3,7-二氢-7-甲基-4H-吡咯并[2,3-D]嘧啶-4-酮

     A TNKS1/2 inhibitor
  38. GC10905 Amodiaquine dihydrochloride dihydrate

    阿莫地喹盐酸盐; Amodiaquin dihydrochloride dihydrate

     A prodrug form of N-desethyl amodiaquine
  39. GC16509 Adox

    腺苷二醛

     An irreversible inhibitor of SAH hydrolase
  40. GC16261 LLY507 A SMYD2 inhibitor
  41. GC16647 Daprodustat(GSK1278863)

    达普司他,GSK1278863

     A HIF-PH1, -2, and -3 inhibitor
  42. GC15102 EPZ020411 A PRMT6 inhibitor
  43. GC14380 BGP-15

    (Z)-N-(2-羟基-3-(哌啶-1-基)丙氧基)烟酰胺双盐酸盐

     A PARP inhibitor and insulin sensitizer
  44. GC17546 AMI5

    水溶伊红,Acid Red 87

     曙红 Y（二钠）是一种可溶性酸性红色染料分子。
  45. GC17820 AS8351

    NSC51355

     A histone demethylase inhibitor
  46. GC16224 EPZ031686 EPZ031686 是一种有效且具有口服活性的 SMYD3 抑制剂，IC50 值为 3 nM。 EPZ031686 可用于癌症研究。
  47. GC17472 Oxamflatin

    Metacept-3

     Inhibitor of histone deacetylases
  48. GC12288 GSK-J1 sodium salt A dual inhibitor of JMJD3 and UTX
  49. GC12874 SGC707 A potent allosteric inhibitor of PRMT3
  50. GC17555 NVP-TNKS656

    TNKS656

     A TNKS2 inhibitor
  51. GC17207 UNC3866 An inhibitor of CBX7

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