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JGB1741 Sale

(Synonyms: ILS-JGB-1741) 目录号 : GC13062

A SIRT1 inhibitor

JGB1741 Chemical Structure

Cas No.:1256375-38-8

规格 价格 库存 购买数量
1mg
¥625.00
现货
5mg
¥2,781.00
现货
10mg
¥4,450.00
现货
25mg
¥8,807.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

JGB1741 is a small molecule SIRT1 inhibitor [1].

Sirtuins or Sir2 (silent information regulator 2)-related enzymes have originally been defined as a family of nicotinamide adenine dinucleotide-dependent enzymes which are involved in deacetylating lysine residue on multiple proteins. The sirtuins show highly conservation from archaebacteria to eukaryotes. The mammalian sirtuins SIRT1–SIRT7 have been implicated in a variety of cellular functions, such as gene silencing, over the control of the cell cycle and apoptosis, to energy homeostasis [2].

In vitro: JGB1741 potently inhibited the proliferation of human metastatic breast cancer cells, MDA-MB 231. JGB1741 showed antitumor effects on three different cancer cell lines, K562, HepG2 and MDA-MB 231 with an IC50 of 1, 10 and 0.5 μM, respectively. JGB1741-induced apoptosis has been associated with increase in cytochrome c release, modulation in Bax/Bcl2 ratio and cleavage of PARP [1].

References:
[1] Kalle A M, Mallika A, Badiger J, et al.  Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells[J]. Biochemical and biophysical research communications, 2010, 401(1): 13-19.
[2] Yamamoto H, Schoonjans K, Auwerx J.  Sirtuin functions in health and disease[J]. Molecular Endocrinology, 2007, 21(8): 1745-1755.

Chemical Properties

Cas No. 1256375-38-8 SDF
别名 ILS-JGB-1741
化学名 4,5,6,7-tetrahydro-2-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(phenylmethyl)-benzo[b]thiophene-3-carboxamide
Canonical SMILES OC1=C(/C=N/C2=C(C(NCC3=CC=CC=C3)=O)C(CCCC4)=C4S2)C(C=CC=C5)=C5C=C1
分子式 C27H24N2O2S 分子量 440.6
溶解度 ≤0.2mg/ml in DMSO;0.14mg/ml in dimethyl formamide 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.2696 mL 11.3482 mL 22.6963 mL
5 mM 0.4539 mL 2.2696 mL 4.5393 mL
10 mM 0.227 mL 1.1348 mL 2.2696 mL
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