Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. 产品名称 Information
GC19098 CeMMEC1 A selective TAF1 bromodomain 2 inhibitor
GC19092 CCT241736 A dual inhibitor of Aurora kinases and FLT3
GC19038 ARV-825 A BRD4 inhibitor that drives BRD4 degradation
GC19020 ACY-738
N-羟基-2-[(1-苯基环丙基)氨基]-5-嘧啶甲酰胺
An HDAC6 inhibitor
GC19013 3-TYP
吡啶-3-乙炔
3-TYP 抑制 SIRT3，IC50 为 16 nM，比 SIRT1 和 SIRT2 更有效，IC50 分别为 88 nM 和 92 nM。
GC18949 CAY10677
Icmt Inhibitor 15
An inhibitor of protein prenylation
GC18925 Cl-Amidine (hydrochloride)
N-[(1S)-1-(氨基羰基)-4-[(2-氯-1-亚氨基乙基氨基]丁基]-苯甲酰胺盐酸盐
A PAD inhibitor
GC18915 Trapoxin A Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor.
GC18731 LP99 A selective inhibitor of BRD7/9
GC18729 MZ1 A PROTAC that drives BRD4 degradation
GC18650 S-(5'-Adenosyl)-L-methionine (tosylate)
AdoMet, SAM, SAMe

S-Adenosyl-L-methioninetosylate(S-Adenosylmethioninetosylate)是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和ATP内源性生产的，是一种重要的具有口服活性的甲基供体。
GC18642 SW155246 A DNA methyltransferase 1 inhibitor
GC18623 α-Hydroxyglutaric Acid
2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid
An α-hydroxy acid
GC18577 CID-2818500
Α-硝基茋
An inhibitor of PRMT1
GC18509 3-Methylcytidine (methosulfate)
3-甲基胞苷甲基硫酸酯
An internal standard for HPLC
GC18508 BAY-299 A potent and selective BRD1 inhibitor
GC18428 SGC2085 (hydrochloride) A PRMT4/CARM1 inhibitor
GC18408 BML-278
DIETHYL1-BENZYL-4-PHENYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE锛圵S201542锛,WUXIAPPTEC"
An activator of SIRT1, SIRT2, and SIRT3
GC18402 GSK3117391 An HDAC inhibitor
GC18236 Echinomycin
醌霉素A,Antibiotic A 654I； NSC 13502； NSC 526417； Quinomycin A； SK 302B
An inhibitor of HIF-1-mediated gene transcription
GC18228 CAY10602
1-(4-氟苯基)-3-(苯磺酰基)-1H-吡咯并[2,3-B]喹喔啉-2-胺
A SIRT1 activator
GC18206 WT161 A potent inhibitor of HDAC6
GC18172 E7449
E7449; 2X-121
An inhibitor of PARP1, PARP2, and TNKS1/2
GC18161 BCI-121 An inhibitor of SMYD3
GC18159 BAY-598 An inhibitor of SMYD2
GC18153 WM-8014
WM8014,WM 8014
An inhibitor of KAT6A and KAT6B
GC12530 PFI-2 (hydrochloride)
(R)-PFI-2 hydrochloride
GC11302 Hinokitiol
桧木醇; β-Thujaplicin
A tropolone with diverse biological activities
GC15711 Aurora Kinase Inhibitor III A potent inhibitor of Aurora A kinase
GC11792 OG-L002 HCl An LSD1 inhibitor
GC16811 Vadadustat
伐度司他,PG-1016548; AKB-6548
An inhibitor of HIF-PH2 and HIF-PH3
GC17724 Thiomyristoyl
TM
A potent and selective SIRT2 inhibitor
GC12367 CM-272 An inhibitor of G9a, GLP, and DNA methyltransferases
GC14524 CTPB A selective activator of p300 HAT
GC15931 AGK7
SIRT2 Inhibitor (Inactive Control)
An inactive control for AGK2
GC13088 BRD6688 A kinetically selective HDAC2 inhibitor
GC14686 JFD00244
BML-266
An inhibitor of SIRT2
GC16114 Bizine An LSD1 inhibitor
GC11716 SIRT1/2 Inhibitor IV
Cambinol,NSC 112546,SIRT1 Inhibitor II,SIRT2 Inhibitor VI
Cell-permeable inhibitor of SIRT1 and SIRT2
GC12630 MS37452 An inhibitor of CBX7 chromodomain binding to H3K27me3
GC12009 HAT Inhibitor II
组蛋白乙酰转移酶抑制剂II,Histone Acetyltransferase Inhibitor II
An inhibitor of HAT p300
GC13634 (S)-PFI-2 (hydrochloride)
(+)-PFI-2
Negative control of (R)-PFI 2
GC14016 Sulforaphane
萝卜硫素

萝卜硫素 (SFN) 称为 [1-isothiocyanato-4-(methylsulfinyl)butane]。
GC15379 JNJ-42041935
HIF-PHD Inhibitor II
A selective inhibitor of HIF-PH enzymes
GC15974 bpV(HOpic) (potassium salt, technical grade)
Bisperoxovanadium(HOpic)
A PTEN inhibitor
GC12255 IOX4 A selective, bioavailable inhibitor of HIF-PH2
GC15969 PTP Inhibitor IV
Protein Tyrosine Phosphatase Inhibitor IV
An active-site directed inhibitor of protein tyrosine phosphatases
GC10408 2-D08 An inhibitor of sumoylation
GC11806 β-Glycerophosphate (sodium salt hydrate)
五水β-甘油磷酸钠(二钠五水合物)

An inhibitor of alkaline phosphatase
GC12775 2',3',5'-triacetyl-5-Azacytidine
三乙酰基-阿扎胞苷
A prodrug form of 5-azacytidine