Cell Cycle/Checkpoint(细胞周期/检查点)
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more
Products for Cell Cycle/Checkpoint
- ATM/ATR(28)
- Aurora Kinase(52)
- Cdc42(4)
- Cdc7(3)
- Chk(13)
- c-Myc(20)
- CRM1(8)
- Cyclin-Dependent Kinases(69)
- E1 enzyme(1)
- G-quadruplex(11)
- Haspin(6)
- HMTase(1)
- Kinesin(23)
- Ksp(4)
- Microtubule/Tubulin(215)
- Mps1(13)
- Mitotic(7)
- RAD51(13)
- ROCK(59)
- Rho(13)
- PERK(10)
- PLK(34)
- PTEN(6)
- Wee1(6)
- PAK(20)
- Arp2/3 Complex(8)
- Dynamin(10)
- ECM & Adhesion Molecules(40)
- Cytoskeleton & Motor Proteins(53)
- Endomembrane System & Vesicular Trafficking(26)
- G1(38)
- Genotoxic Stress(18)
- G2/M(26)
- G2/S(10)
- Inositol Phosphates(20)
- Proteolysis(98)
- Cellular Chaperones(8)
- Cat.No. 产品名称 Information
- GC45944 para-amino-Blebbistatin A more stable and less phototoxic form of (–)-blebbistatin with enhanced water solubility
- GC38845 sAJM589 sAJM589 是一种 Myc 抑制剂,能干扰 Myc- max 异二聚体的形成,其 IC50 值为 1.8 μM。
- GC38791 GSK-25 GSK-25 是一种有效的、选择性的,具有口服活性的 ROCK1 抑制剂 (IC50=7 nM)。GSK-25 对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性 (RSK1: IC50=398 nM, p70S6K: IC50=1 μM)。GSK-25 可抑制 P450 (CYP2C9、CYP2D6、CYP3A4的IC50 分别为2.5、5.2、2.5 μM)。
- GC38783 Ginkgolic acid C17:1 A phenolic acid with antibacterial and anticancer activities
- GC45903 Quazinone A PDE3 inhibitor
- GC45890 (+)-Abscisic Acid-d6 An internal standard for the quantification of (+)-abscisic acid
- GC45877 CYM 5478 An S1P2 agonist
- GC45846 PKUMDL-LC-101-D04 An allosteric activator of GPX4
- GC45833 N-Oleoyl-L-phenylalanine An N-acyl amide
- GC45809 AMG-Tie2-1 A Tie2 and VEGFR2 inhibitor
- GC45798 Rhein-13C4 An internal standard for the quantification of rhein
- GC45783 1,2-Dioleoyl-rac-glycerol-13C3 An internal standard for the quantification of 1,2-dioleoyl-rac-glycerol
- GC45769 Vandetanib-d6 An internal standard for the quantification of vandetanib
- GC45758 Paclitaxel octadecanedioate A prodrug form of paclitaxel
- GC45750 Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate) An actin-sequestering peptide
- GC45744 monoMICAAc A solvatochromic fluorescent pH probe
- GC45743 ICAAc A solvatochromic fluorophore and pH probe
- GC45688 STX140 An estrogen sulfamate
- GC45680 Prodan A solvatochromic fluorescent probe
- GC45668 Gly-Arg-AMC (hydrochloride) A fluorogenic substrate for cathepsin C
- GC45667 N-(p-Tosyl)-GPR-pNA (acetate) A colorimetric thrombin substrate
- GC45639 Hexapeptide-11 (acetate) A synthetic hexapeptide
- GC45616 C6 Urea Ceramide An inhibitor of neutral ceramidase
- GC38589 MYCi361 MYCi361 is a MYC inhibitor that engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 binds to MYC with Kd of 3.2 μM. MYCi361 suppresses in vivo tumor growth, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.
- GC38588 MYCi975 MYCi975 (NUCC-0200975) is a potent, selective and orally active inhibitor of MYC that disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 exhibits potent anti-tumor activities.
- GC38564 Deoxypodophyllotoxin A flavolignan with diverse biological activities
- GC38519 Ilorasertib hydrochloride A multi-kinase inhibitor
- GC38480 Vat-Cit-PAB-Monomethyl Dolastatin 10 Vat-Cit-PAB-Monomethyl Dolastatin 10 是抗体-药物偶联物的一部分,由 Monomethyl Dolastatin 10 (一种有效的微管蛋白抑制剂) 和 ADC linker Vat-Cit-PAB 连接而成。
- GC38468 DM4-SMe DM4-SMe 是抗体-美登素偶联物 (AMC) 的代谢产物,是一种微管蛋白 (tubulin) 抑制剂,还是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分,可通过二硫键或稳定的硫醚键与抗体连接。DM4-SMe 抑制 KB 细胞的增殖,IC50 值为 0.026 nM。
- GC38460 DM4-SPDP DM4-SPDP 是由连接桥 SPDP 和 毒性分子 DM4 连接而成的,可用来制备抗体偶联药物。DM4 是抑制细胞分裂的抗微管蛋剂。SPDP 是一种短链交联剂,可通过 NHS-酯和吡啶基二硫醇反应性基团与半胱氨酸巯基形成可裂解的 (可还原的) 二硫键,实现胺与巯基的结合。
- GC38456 Pironetin An inhibitor of microtubule assembly
- GC38410 Vincristine An antimitotic inhibitor of tubulin polymerization
- GC38403 LDN-192960 hydrochloride An inhibitor of haspin and DYRK2
- GC38397 MMAF sodium An auristatin with anticancer activity
- GC38355 DM3-SMe DM3-SMe 是一种美登素衍生物,是一种微管蛋白 (tubulin) 抑制剂,是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分,可通过二硫键或稳定的硫醚键与抗体连接。DM3-SMe 在体外显示出高度的细胞毒性活性,IC50 为 0.0011 nM。
- GA23742 Z-D-Arg-Gly-Arg-pNA . 2 HCl A colorimetric Factor Xa substrate
- GA23633 T-Peptide T-peptide 是一种 Tuftsin 类似物,可用于人类免疫缺陷病毒 (HIV) 感染的研究。
- GA23570 Suc-Tyr-Val-Ala-Asp-pNA A colorimetric caspase-1 and -4 substrate
- GA23337 Oxythiamine . HCl A thiamine antimetabolite
- GA22303 H-D-Pro-Phe-Arg-pNA . 2 HCl A colorimetric plasma kallikrein substrate
- GA21951 H-4-Nitro-Phe-OEt . HCl A building block
- GA21397 Dolastatin 15 A peptide with anticancer activity
- GA20494 Ac-Asp-Glu-Val-Asp-pNA A colorimetric caspase substrate
- GC45595 Vulpinic Acid A lichen metabolite with diverse biological activities
- GC45552 Pyrenophorol A fungal metabolite with diverse biological activities
- GC45538 Oxychlororaphine A microbial metabolite with diverse biological activities
- GC45534 OH-Chol A cationic cholesterol derivative
- GC45523 Nemorosone A PPAP with antiproliferative properties
- GC45515 MX1013 A dipeptide pan-caspase inhibitor
- GC45471 H-Gly-Arg-pNA (hydrochloride) A colorimetric thrombin substrate