Neuroscience(神经科学)
Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more
Products for Neuroscience
- 5-HT Receptor(400)
- AChR(53)
- AChE(101)
- Alzheimer(83)
- Amyloid β(119)
- BACE(4)
- CGRP (29)
- COX(279)
- DAPK(5)
- Dopamine Receptor(281)
- GABA Receptor(143)
- Gap Junction(16)
- GluR(117)
- Histamine(2)
- Histamine Receptor(228)
- mPEGS-1(4)
- Muscarinic Receptor(41)
- Neuroscience Peptides(38)
- Nicotinic Receptor(63)
- P2 Receptor(2)
- P2X7 receptor(3)
- SSRIs(5)
- Substance P/NK1 Receptor(20)
- NMDA(2)
- Beta-secretase(24)
- CaMK(28)
- Dopamine Transporter(17)
- Monoamine Oxidase(78)
- Serotonin Transporter(54)
- nAChR(91)
- iGluR(148)
- Neurokinin Receptor(70)
- MCHR1 (GPR24)(16)
- mAChR(170)
- GPR139(3)
- Cholecystokinin Receptor(23)
- Behavioral Neuroscience(270)
- Huntington(9)
- Neuroendocrinology(39)
- Neuroprotection(79)
- Ophthalmology(115)
- Pain Research(162)
- Parkinson(48)
- Prion(6)
- Seizure Disorders(73)
- Cholinesterases(13)
- Cat.No. 产品名称 Information
- GC52414 [Ala17]-MCH (trifluoroacetate salt) An MCH-derived peptide and MCH receptor agonist
- GC52412 TT-232 (trifluoroacetate salt) A synthetic peptide derivative of somatostatin
- GC52411 Exendin-4 (5-39) amide (trifluoroacetate salt) An antagonist of the GLP-1 receptor
- GC52409 BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt) A neuropeptide and MRGPRX1 agonist
- GC52407 BAM-22P (human, mouse, rat, bovine) (trifluoroacetate salt) A neuropeptide
- GC52403 Ivermectin-d2 An internal standard for the quantification of ivermectin
- GC52399 Norephedrine-d5 (hydrochloride) An internal standard for the quantification of norephedrine
- GC52391 306-O12B-3 An ionizable cationic lipidoid
- GC52390 Spexin 1 (human, mouse, rat, bovine) (acetate) An endogenous peptide and agonist of GAL2 and GAL3
- GC52389 Caveolin-1 (82-101) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) A synthetic peptide fragment of caveolin-1
- GC52388 [D-Lys3]-GHRP-6 (trifluoroacetate salt) An antagonist of GHS-R1a
- GC52385 Myelin Basic Protein (85-99) Peptide Antagonist (trifluoroacetate salt) An MBP (85-99) antagonist
- GC52382 Nogo-66 (1-40) (human, mouse, rat) (trifluoroacetate salt) A peptide fragment of Nogo-A
- GC52354 Tertiapin Q (trifluoroacetate salt) A peptide derivative of tertiapin
- GC52342 P4pal10 (trifluoroacetate salt) A PAR4 and FPR2 antagonist and an FFAR2 agonist
- GC52332 Arimoclomol A co-inducer of heat shock proteins
- GC52331 Lactoyl Phenylalanine A secondary metabolite
- GC52329 Betamethasone-d5 An internal standard for the quantification of betamethasone
- GC52328 KYL (trifluoroacetate salt) An EphA4 inhibitor
- GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate A metabolite of certain phenols and glycosides
- GC52323 L-Isoleucine-13C6 An internal standard for the quantification of L-isoleucine
- GC52310 L-Arginine-13C6 (hydrochloride) An internal standard for the quantification of L-arginine
- GC52303 Ethyl Mycophenolate A potential impurity found in commercial preparations of mycophenolate mofetil
- GC52283 L-Cysteine-15N-d3 An internal standard for the quantification of L-cysteine
- GC52278 Creatine Phosphate (sodium salt hydrate) A phosphorylated form of creatine
- GC52274 Y-33075 (hydrochloride) An inhibitor of ROCK2
- GC52270 Pranoprofen-13C-d3 An internal standard for the quantification of pranoprofen
- GC52264 Latanoprost tris(triethylsilyl) ether A precursor in the synthesis of latanoprost
- GC52262 Tolterodine Dimer A potential impurity in commercial preparations of tolterodine
- GC52251 Imidacloprid Impurity 1 A potential impurity in commercial preparations of imidacloprid
- GC52243 Corynantheidine An alkaloid with antinociceptive activity
- GC52214 Nicotinamide riboside-d4 (triflate) An internal standard for the quantification of nicotinamide riboside
- GC67620 Methacholine bromide Methacholine (Acetyl-β-methylcholine) bromide 是一种有效的 muscarinic-3 (M3) 激动剂。Methacholine bromide 直接作用于平滑肌上的乙酰胆碱受体,导致支气管收缩和气道变窄。Methacholine bromide 对识别支气管高反应性 (BHR) 显示出高灵敏度。Methacholine bromide 可用于测量气道高反应性 (AHR),作为评估具有哮喘样症状和正常静息呼气流速的个体的诊断辅助[2]。
- GC66843 L-Homocysteic acid L-Homocysteic acid (L-HCA) 是一种内源性兴奋性氨基酸,可作为 NMDA 受体激动剂 (EC50: 14 μM)。L-Homocysteic acid 具有神经毒性,可用于神经系统疾病的研究。
- GC66445 Dimethindene maleate Dimethindene maleate 是一种选择性的 histamine H1 拮抗剂,具有抗组胺效应。Dimethindene maleate 可用于过敏性反应的研究。
- GC66431 NCRW0005-F05 NCRW0005-F05 是一种有效的 GPR139 激动剂,IC50 为 0.21 μM。NCRW0005-F05 可用于糖尿病、肥胖症和帕金森的研究。
- GC66429 Phenacetin-d5 Phenacetin-d5 (Acetophenetidin-d5) 是 Phenacetin 的氘代物。Phenacetin (Acetophenetidin) 是一种非阿片类解热化合物,可用于缓解疼痛的研究。Phenacetin 是一种选择性的 COX-3 抑制剂。Phenacetin 能作为人肝微粒体和大鼠体内 CYP1A2 的探针。
- GC66416 β-Amyloid (22-35) (TFA) β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA,β-淀粉样蛋白的 22-35 残基片段,对无血清培养的大鼠海马神经元具有细胞毒性作用。β-Amyloid 22-35 TFA 在中性缓冲液中形成聚集体和典型的淀粉样纤维,类似于 β-淀粉样蛋白。
- GC66408 Fremanezumab Fremanezumab (TEV-48125) 是一种人源化 IgG2a 单克隆抗体,可选择性且有效地与降钙素基因相关肽 (CGRP) 结合。CGRP 是一种 37 个氨基酸的神经肽,参与偏头痛的中枢和外周病理生理事件。Fremanezumab 具有用于慢性偏头痛研究的潜力。
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GC66406
Aducanumab
Aducanumab (BIIB037),一种人单克隆抗体,对β淀粉样蛋白 (Aβ) 的聚集形式具有选择性。Aducanumab 显示出脑渗透性,可用于阿尔茨海默病 (AD) 研究。
- GC66402 Galcanezumab Galcanezumab (LY 2951742) 是一种针对 CGRP 配体的人源化 IgG4 单克隆抗体。Galcanezumab 可用于偏头痛或丛集性头痛的研究。
- GC66346 β-Amyloid (42-1), human TFA β-Amyloid (42-1), human TFA 是淀粉样蛋白 β 肽 (1-42) 的无活性形式。β-Amyloid (42-1), human TFA 是由 42 个氨基酸组成的肽,其在阿尔茨海默病的发病机制中起关键作用。
- GC66258 Propacetamol A prodrug form of acetaminophen
- GC66255 (E)-3,4,5-Trimethoxycinnamic acid (E)-3,4,5-Trimethoxycinnamic acid (TMCA) 是一种被多甲氧基取代的肉桂酸。(E)-3,4,5-Trimethoxycinnamic acid 是一种口服有效的 GABAA/BZ 受体激动剂。(E)-3,4,5-Trimethoxycinnamic acid 与 5-HT2C 和 5-HT1A 受体具有良好的结合亲和力,其 IC50 值分别为 2.5 和 7.6 μM。(E)-3,4,5-Trimethoxycinnamic acid 具有抗惊厥和镇静活性。(E)-3,4,5-Trimethoxycinnamic acid 可用于失眠、头痛、癫痫的研究。
- GC66211 Ibuprofen sodium Ibuprofen ((±)-Ibuprofen) sodium 是一种具有口服活性的 COX-1 选择性抑制剂,IC50 值为 13 μM。Ibuprofen sodium 抑制细胞增殖、血管生成,并诱导细胞凋亡 (apoptosis)。Ibuprofen sodium 是一种非甾体抗炎试剂和一氧化氮 (NO) 供体。Ibuprofen sodium 可用于疼痛、肿胀、炎症、感染、免疫学、癌症的研究。
- GC66089 β-Amyloid (1-40) (TFA) β-Amyloid (1-40) TFA 是阿尔茨海默症患者脑斑块中发现的一种主要蛋白片段。
- GC66073 Flupyradifurone Flupyradifurone 是一种 nAChR 激动剂,可干扰害虫中枢神经系统的信号转导,可用作杀虫剂。
- GC66072 Buntanetap Buntanetap ((+)-Phenserine) 是新型的 cholinesterase 非竞争性抑制剂。IC50 值为 45.3 μM。
- GC65983 5-HT3 antagonist 5 5-HT3 antagonist 5 是一种喹喔啉 -2- 甲酰胺化合物,是 5-HT3 受体拮抗剂。5-HT3 antagonist 5 对 5-HT3 激动剂和 2- 甲基 -5-HT 也具有拮抗作用,并在小鼠中表现出抗抑郁效果。
- GC65979 AChE-IN-27 AChE-IN-27 (化合物 8c) 是一种 AChE 抑制剂 (IC50=0.19 µM)。AChE-IN-27 可用于神经系统疾病,如阿尔茨海默病、老年痴呆、共济失调和重症肌无力得研究。