MAPK Signaling(MAPK信号通路)

Cat.No. 产品名称 Information

GC43341 Cyclic GMP

A second messenger

GC43339 Cyclic di-AMP (sodium salt) A bacterial second messenger

GC43332 Cuspin-1 An upregulator of SMN protein

GC43198 CAY10717 A multi-targeted kinase inhibitor

GC43167 CAY10561 A selective inhibitor of ERK

GC43065 C2 Phytoceramide (t18:0/2:0) A bioactive sphingolipid

GC42968 BPIQ-II (hydrochloride) A potent, selective EGFR inhibitor

GC42622 8-bromo-Cyclic AMP A PKA activator

GC42616 7-oxo Staurosporine An antibiotic with diverse biological activities

GC41740 (S)-p38 MAPK Inhibitor III A cell-permeable p38 MAP kinase inhibitor

GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol A cytochrome P450 metabolite of 2-AG

GC41635 Phosphodiesterase 4 Inhibitor An inhibitor of PDE4

GC41573 Theaflavin 3,3'-digallate

A polyphenol with diverse biological activities

GC41423 5-trans Prostaglandin E2 An impurity in commercial lots of PGE₁

GC40650 CAY10706 A TrxR inhibitor

GC40484 Ferulic Acid methyl ester A lipophilic antioxidant

GC40352 Cafestol A natural diterpene which increases serum cholesterol

GC34918 MW-150 dihydrochloride dihydrate An inhibitor of p38α MAPK

GC34831 Tauroursodeoxycholate dihydrate Tauroursodeoxycholatedihydrate(TUDCAdihydrate;UR906dihydrate;Taurolitedihydrate)是一种内质网应激抑制剂。Tauroursodeoxycholate显著降低凋亡分子如caspase-3和caspase-12表达。Tauroursodeoxycholate也抑制ERK。

GC34650 Longdaysin

Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7.

GC19507 LUT-014 LUT-014 是一种 B-Raf 抑制剂，IC50 为 11.7 nM，用于减少与 EGFR 抑制剂治疗相关的剂量限制性痤疮样病变。

GC40213 Regorafenib-13C-d3 An internal standard for the quantification of regorafenib

GC40054 CCT241161 A multi-kinase inhibitor

GC34342 BAY885 An ERK5 inhibitor

GC34275 L-JNKI-1 L-JNKI-1是一种针对JNK的细胞渗透性多肽抑制剂。

GC34208 GNE 220 Hydrochloride GNE220(Hydrochloride)是一种有效的选择性MAP4K4抑制剂，其IC50值为7nM。

GC34197 FMK-MEA

FMK-MEA 是一种有效的选择性 p90 核糖体 S6 激酶 (RSK) 抑制剂。

GC34181 Tauroursodeoxycholate (TUDCA) 牛磺酸脱氧胆酸盐(TUDCA)是包括肝细胞在内的多种细胞的细胞保护剂,也是癌症细胞凋亡的诱导剂。牛磺酸脱氧胆酸盐作为一种内质网应激抑制剂,通过减少内质网应激,有效地保护肝细胞和恢复葡萄糖稳态。.

GC34140 TC13172

TC13172是MLKL的抑制剂，作用于HT-29细胞，其EC50值为2nM。

GC34072 Talmapimod (SCIO-469) A p38 MAPK inhibitor

GC34057 TBHQ (tert-Butylhydroquinone) Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.

GC33857 Omtriptolide Omtriptolide(PG490-88)是从中草药纯化的雷公藤内酯的水溶性衍生物前药。

GC33844 Isovitexin (Saponaretin) A C-glycosylated flavone with diverse biological activities

GC33831 Lidocaine hydrochloride (Lignocaine hydrochloride) An Analytical Reference Standard

GC33771 Metadoxine Metadoxine (Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat), also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication. Metadoxine is a novel 5-HT2B receptor antagonist with a possible therapeutic role in treating ADHD.

GC33388 MEK-IN-1 MEK-IN-1是来自专利WO2008076415A1的MEK抑制剂。

GC33305 Balamapimod (MKI 833) Balamapimod (MKI 833) (MKI 833) 是一种可逆的 Ras/Raf/MEK 抑制剂，具有潜在的抗肿瘤活性。

GC33238 SJFδ SJFδ是一种含10个原子连接桥的PROTAC。SJFδ降解p38α，DC50为46.17nM，但不降解其他p38亚型(p38α,p38β和p38γ)。

GC33229 SJFα SJFα是一种含13个原子连接桥的PROTAC。SJFα降解p38α，DC50为7.16nM，但降解p38δ效果较差(DC50=299nM)，且在浓度高达2.5μM时也不会降解其他p38亚型(β和γ)。

GC33206 ERK-IN-1 ERK-IN-1（化合物 B）是一种可口服的 ERK1 和 ERK2 抑制剂，用于治疗以激活 MAPK 通路突变为特征的增殖性疾病。该活性尤其与 KRAS 突变 NSCLC、BRAF 突变 NSCLC、KRAS 突变胰腺癌、KRAS 突变结直肠癌 (CRC) 和 KRAS 突变卵巢癌的治疗有关。 ERK-IN-1 hydrochloride 也可以抑制 RAF。

GC33142 MK2-IN-1 (MK2 Inhibitor) MK2-IN-1 (MK2 Inhibitor) 是一种有效的、选择性的 MAPKAPK2(MK2) 抑制剂 (IC50=0.11 uM)，具有非 ATP 竞争性结合模式。

GC33123 GNE 220 GNE-220是一种有效的选择性MAP4K4抑制剂，IC50为7nM。

GC33051 KO-947 An ERK inhibitor

GC33033 ETC-206 An inhibitor of MKNK1 and MKNK2

GC33008 p38 MAPK-IN-1 p38MAPK-IN-1是p38MAPK新型高效选择性抑制剂,IC50值68nM。

GC32983 Juglanin Juglanin是一个JNK激活剂。

GC32950 Belvarafenib An inhibitor of B-RAF and C-RAF

GC32937 SLV-2436 (SEL201-88) SEL-201 (SLV-2436, SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50 of 10.8 ?nM and 5.4 nM, respectively.

GC32900 CC-90003 CC-90003 is an irreversible inhibitor of ERK1/2 with IC50s in the 10-20 nM range and shows good kinase selectivity in a 258-kinase biochemical assay.

GC32797 AD80 AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.

MAPK Signaling(MAPK信号通路)

Products for MAPK Signaling