Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. 产品名称 Information
GN10347 Nicotinamide (Vitamin B3)
烟酰胺; Niacinamide; Nicotinic acid amide
Nicotinamide (Vitamin B3)是维生素B3的酰胺衍生物，可以抑制SIRT1（IC₅₀：50-180μM）和SIRT2（IC₅₀：2μM）的活性。Nicotinamide还可增加细胞中NAD⁺、ATP、ROS水平。
GN10357 Parthenolide
小白菊内酯; (-)-Parthenolide
Parthenolide是一种NF-κB抑制剂，对Eca109、KYSE-510、SiHa和MCF-7细胞48h的IC₅₀值分别约为10.3、13.3、8.42和9.54µM。
GC13822 (-)-JQ1
(S)-(+)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂卓-6-基)乙酸叔丁酯,(-)-JQ1
A selective inhibitor of BET bromodomains
GC12961 Apicidin
OSI 2040

A cell-permeable HDAC inhibitor
GC11334 Romidepsin (FK228, depsipeptide)
罗米地辛; FK 228; FR 901228; NSC 630176
A class I HDAC inhibitor
GC15526 Trichostatin A (TSA)
曲古抑菌素A; TSA
Trichostatin A (TSA) 是一种有效的组蛋白脱乙酰酶 (HDAC) 抑制剂和抗真菌抗生素，对 HDAC 的 IC50 值为 1.8 nM，具有抑制细胞生长和诱导细胞分化。
GC17907 3-Deazaneplanocin A (DZNep) hydrochloride
3-去氮腺嘌呤A盐酸盐; DZNep hydrochloride; NSC 617989 hydrochloride; 3-Deazaneplanocin hydrochloride
3-Deazaneplanocin A (DZNep) hydrochloride 是一种腺苷类似物，是一种竞争性 S-腺苷高半胱氨酸水解酶抑制剂，在无细胞试验中的 Ki 为 50 pM。
GC12257 Panobinostat (LBH589)
帕比司他; LBH589; NVP-LBH589
A pan-HDAC inhibitor
GC11625 Entinostat (MS-275,SNDX-275)
恩替诺特; MS-275; SNDX-275
A histone deacetylase inhibitor
GC12153 Zebularine
2-嘧啶酮-B-核甙,NSC 309132
A DNA methyltransferase inhibitor
GC15610 UNC0638 A G9a and GLP histone methyltransferase inhibitor
GC13398 RG 108
N-Phthalyl-L-tryptophan,RG108
DNA methyltransferase inhibitor
GC11778 Lomeguatrib
罗米鲁曲,PaTrin-2

Inactivator of O⁶-methylguanine-DNA methyltransferase
GC16531 Bromodomain Inhibitor, (+)-JQ1
(S)-(+)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂卓-6-基)乙酸叔丁酯
A selective inhibitor of BET bromodomains
GC12171 BIX 01294 An inhibitor of G9a histone methyltransferase
GC17275 AMI-1
猩红酸钠盐,Arginine N - methyltransferase inhibitor - 1
A cell permeable inhibitor of PRMTs
GC10946 5-Azacytidine
5-氮杂胞苷; Azacitidine; 5-AzaC; Ladakamycin
5-氮胞苷（也称为 5-AzaC）是一类胞嘧啶类似物的化合物，是一种 DNA 甲基转移酶 (DNMT) 抑制剂，对多发性骨髓瘤 (MM) 细胞（包括 MM.1S）具有强效细胞毒性, MM.1R, RPMI-8266, RPMI-LR5, RPMI-Dox40和Patient-derived MM,半数抑制浓度IC50值分别为1.5 μmol/L, 0.7 μmol/L, 1.1 μmol/L, 2.5 μmol/L , 分别为 3.2 μmol/L 和 1.5 μmol/L . 5-氮胞苷掺入细胞 DNA 和/或 RNA，随后螯合 DNMT 并在 5-氮胞苷的 C6 和半胱氨酸之间形成共价键DNMT 的硫醇盐导致细胞中 DNMT 活性的耗竭和细胞 DNA 的去甲基化。
GC15255 Decitabine(NSC127716, 5AZA-CdR)
地西他滨; 5-Aza-2'-deoxycytidine; 5-AZA-CdR; NSC 127716
地西他滨(Decitabine, DAC)是一种具有口服生物活性的脱氧胞苷类似物抗代谢物,具有DNA甲基转移酶抑制剂的功能。
GC13145 3-Deazaneplanocin,DZNep
3-去氮腺嘌呤A; DZNep; 3-Deazaneplanocin

An inhibitor of lysine methyltransferase EZH2
GP10020 Histone-H2A-(107-122)-Ac-OH
Ac-Gly-Val-Leu-Pro-Asn-Ile-Gln-Ala-Val-Leu-Leu-Pro-Lys-Lys-Thr-Glu-OH

Histone-H2A peptide