Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. 产品名称 Information
GC12450 BI 2536
BI-2536;BI2536
A potent inhibitor of Plk1
GC16277 α-Amanitin
alpha-鹅膏覃碱; α-Amatoxin
A selective RNA polymerase II inhibitor
GC12020 TCS 401 A selective PTP1B inhibitor
GC17762 NSC 33994 NSC 33994 (G6) 是一种选择性 JAK2 抑制剂，IC50 为 60 nM。
GC16973 DMOG
二甲基乙二酰氨基乙酸,Dimethyloxallyl Glycine
DMOG（二羟基丙氨酸）是 α-酮戊二酸辅助因子的拮抗剂和 HIF-脯氨酸羟化酶的抑制剂，导致 HIF-1α 蛋白在细胞核中的稳定和积累。
GC15688 UNC 0224 A potent inhibitor of G9a histone methyltransferase
GC12019 TCS HDAC6 20b An HDAC6 inhibitor
GC13237 LMK 235
N-[[6-(羟基氨基)-6-氧代己基]氧基]-3,5-二甲基-苯甲酰胺
A selective inhibitor of HDAC4 and HDAC5
GC11972 NU 9056 NU 9056 是一种有效且选择性的 Tip60 (KAT5) 组蛋白乙酰转移酶抑制剂，浓度为 2 µM。 NU 9056 对 Tip60 的选择性比 PCAF、p300 和 GCN5 高 16 倍以上。 NU 9056 诱导前列腺癌细胞凋亡。
GC10174 SGC-CBP30
SGCCBP30,SGC CBP30
A potent inhibitor of CREBBP/EP300 bromodomains
GC16378 TC-A 2317 hydrochloride TC-A 2317 hydrochloride 是一种具有口服活性的 Aurora A 激酶抑制剂 (Ki=1.2 nM)。 TC-A 2317 hydrochloride 对 Aurora B 激酶 (Ki=101 nM) 和其他 60 种激酶具有出色的选择性、良好的细胞渗透性和良好的 PK 曲线。抗肿瘤活性。
GC17241 Thiolutin
硫藤黄素,Acetopyrrothin
An inhibitor of Hsp27 and RNA polymerases
GC15060 Mithramycin A
光辉霉素,Mithramycin A
A DNA-binding antitumor antibiotic
GC10169 NSC 87877 A potent inhibitor of SHP-1 and SHP-2
GC16256 BVT 948
4-羟基-3,3-二甲基-2H-苯并[G]吲哚-2,5(3H)-二酮
An inhibitor of protein tyrosine phosphatases
GC17344 Alexidine dihydrochloride
己联双辛胍二盐酸盐
An alkyl bis(biguanide) antiseptic
GC14321 Sal 003
(2E)-3-苯基-N-[2,2,2-三氯-1-[[[(4-氯苯基)氨基]硫代甲酰基]氨基]乙基]-2-丙烯酰胺
An inhibitor of eIF2α dephosphorylation
GC16958 Okadaic acid
冈田酸

A potent inhibitor of protein phosphatases
GC17966 NFAT Inhibitor
VIVIT peptide
A peptide inhibitor of NFAT
GC16117 INCA-6
Triptycene-1,4-quinone
A cell-permeant inhibitor of NFAT signaling
GC12604 Fumonisin B1
伏马菌素B1

A mycotoxin
GC14395 Fostriecin sodium salt
福司曲星
A potent inhibitor of protein phosphatases 2A and 4
GC14024 DL-AP3
DL-2-氨基-3-磷丙酸
A metabotropic glutamate receptor antagonist
GC17011 C2 Ceramide
N-乙酰基神经鞘氨醇,C2 Ceramide (d18:1/2:0)， C2 Ceramide ，Ceramide (d18:1/2:0)， Cer(18:1/2:0)，N-acetoyl-D-erythro-sphingosine
C2 Ceramide是一种短链细胞渗透性神经酰胺类似物，可抑制Bcl2蛋白的磷酸化，IC₅₀值为14μmol/L。
GC18106 Calyculin A
蛋白磷酸酯酶抑制剂,(-)-Calyculin A

Calyculin A是蛋白磷酸酶1（PP1）和蛋白磷酸酶2A（PP2A）的强效抑制剂, IC₅₀值分别为2nM和0.5–1.0nM。
GC12743 Calcineurin Autoinhibitory Peptide Calcineurin autoinhibitory peptide 是 Ca2+/calmodulin-dependent protein phosphatase (calcineurin) 的选择性抑制剂，IC50 为 ~10 μM。
GC11674 WIKI4
Tankyrase 1/2 Inhibitor V
A potent TNKS1/2 inhibitor
GC17775 NU 1025
NSC 696807
An inhibitor of PARP
GC12869 JW 55
Tankyrase 1/2 Inhibitor IV
A TNKS1/2 inhibitor
GC12991 EB 47 A PARP1 and TNKS2 inhibitor
GC12680 DR 2313
3,5,7,8-四氢-2-甲基-4H-硫代吡喃并[4,3-D]嘧啶-4-酮
A PARP inhibitor
GC14434 BYK 49187 Potent PARP-1/PARP-2 inhibitor
GC10690 BYK 204165
PARP Inhibitor XIV
A selective inhibitor of PARP1
GC16474 4-HQN
4-羟基喹唑啉
A heterocyclic building block
GC17178 TCS PIM-1 1
SC 204330
A Pim-1 kinase inhibitor
GC13488 R8-T198wt R8-T198wt 是一种细胞可渗透的羧基末端 p27Kip1 肽，通过抑制 Pim-1 激酶表现出抗肿瘤活性。
GC13558 PIM-1 Inhibitor 2
PIMi II
A potent PIM-1 kinase inhibitor
GC12419 UNC 926 hydrochloride An antagonist of L3MBTL1, L3MBTL3, and L3MBTL4
GC15125 ZM 449829
2-萘乙烯基酮
An inhibitor of JAK3
GC16584 TCS 21311
NIBR3049
A JAK3 inhibitor
GC12118 SD 1008
SD 1008 是一种有效的 JAK 抑制剂。 SD 1008 抑制 STAT3、JAK2 和 Src 的酪氨酰磷酸化。 SD 1008 还降低 STAT3 依赖性荧光素酶活性。 SD 1008 通过直接阻断 JAK-STAT3 信号通路增强紫杉醇诱导的卵巢癌细胞凋亡。
GC17033 Lestaurtinib
来他替尼; CEP-701; KT-5555
A potent JAK2 and PRK1 kinase inhibitor
GC13347 Cucurbitacin I
葫芦素I,Elatericin B; JSI-124; NSC-521777
An inhibitor STAT3/JAK signaling
GC15391 Cercosporamide
尾孢素酰胺,(-)-Cercosporamide

A potent inhibitor of fungal Pkc1 and mammalian Mnk isoforms
GC17055 1,2,3,4,5,6-Hexabromocyclohexane
1,2,3,4,5,6-六溴化环己烷
1,2,3,4,5,6-六溴环己烷（1,2,3,4,5,6-Hexabromocyclohexane）直接抑制JAK2激酶结构域内的口袋，抑制自身磷酸化。
GC15594 PX 12
2-(仲丁基二硫基)-1H-咪唑,IV-2
An irreversible inhibitor of thioredoxin-1
GC14319 ML 228
CID-46742353
A HIF pathway activator
GC13141 KC7F2 An inhibitor of HIF-1a protein synthesis
GC17405 Chetomin
毛壳菌素,NSC 289491
An inhibitor of HIF signaling
GC16518 UNC 0646
N-(1-环己基-4-哌啶基)-2-[六氢-4-异丙基-1H-1,4-二氮杂卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺
An inhibitor of G9a/GLP methyltransferases