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Home >> Signaling Pathways >> Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. 产品名称 Information
  2. GC11576 Tranylcypromine (2-PCPA) HCl

    (1S,2R)-2-苯基-环丙胺盐酸盐,(1S,2R)-SKF 385 hydrochloride

     (1S,2R)-Tranylcypromine ((1S,2R)-SKF 385) hydrochloride 是一种有效的抗抑郁剂。
  3. GC17314 OG-L002 An LSD1 inhibitor
  4. GC15259 EPZ004777 HCl EPZ004777 HCl 是一种有效的选择性 DOT1L 抑制剂，IC50 为 0.4 nM。
  5. GC12733 C646 C646是一种有效的选择性p300/CBP组蛋白乙酰转移酶抑制剂(Ki 400 nM),已被证明具有多效性,包括神经保护、抗癌和抗上皮间质转化(anti-EMT)作用。
  6. GC15410 Bufexamac

    丁苯羟酸; Bufexamic acid

     An NSAID and a class IIb HDAC inhibitor
  7. GC16290 Nafamostat hydrochloride

    盐酸萘莫司他

     Nafamostat hydrochloride 是一种合成丝氨酸蛋白酶抑制剂，是一种抗凝剂。
  8. GC17676 Nafamostat

    萘莫司他

     A serine protease inhibitor
  9. GC14490 Donepezil HCl

    盐酸多奈哌齐; E2020

    An AChE inhibitor
  10. GC12579 GLPG0634

    非戈替尼,GLPG0634

     A JAK1 inhibitor
  11. GC10154 ABC294640

    3-(4-氯苯基)-N-(4-吡啶基甲基)金刚烷-1-甲酰胺,ABC294640

     An inhibitor of SPHK2
  12. GC14699 CPI-203 A bioavailable inhibitor of BET bromodomains
  13. GC12698 BAY 87-2243 A mitochondrial complex I inhibitor and inducer of ferroptosis
  14. GC14756 EI1

    6-氰基-N-[(1,2-二氢-4,6-二甲基-2-氧代-3-吡啶基)甲基]-1-(1-乙基丙基)-1H-吲哚-4-甲酰胺,KB-145943

     A selective inhibitor of EZH2
  15. GC14151 CBB1007 CBB1007 是一种细胞可渗透的脒基胍化合物，可作为一种有效的、可逆的和底物竞争性 LSD1 选择性抑制剂（hLSD1 的 IC50 = 5.27 μM）。
  16. GC13103 AZ505 ditrifluoroacetate

    N-环己基-3-[[2-(3,4-二氯苯基)乙基]氨基]-N-[2-[[2-(3,4-二氢-5-羟基-3-氧代-2H-1,4-苯并恶嗪-8-基)乙基]氨基]乙基]丙酰胺二(2,2,2-三氟乙酸盐)

     An inhibitor of SMYD2
  17. GC13744 AZ505

    N-环己基-3-(3,4-二氯苯乙基氨基)-N-[2-[[2-[5-羟基-3-氧代-3,4-二氢-2H-苯并[B][1,4]恶嗪-8-基]乙基]氨基]乙基]丙酰胺

     An inhibitor of SMYD2
  18. GC14063 GSK1324726A

    I-BET726

     A selective inhibitor of BET family proteins
  19. GC13148 MS436 MS436 是一类新的溴结构域抑制剂，对 BRD4 BrD1 具有估计的 Ki=30-50 nM 的强亲和力，对 BrD2 的选择性是 10 倍。
  20. GC12548 UNC 0631 An inhibitor of G9a/GLP methyltransferases
  21. GC15747 I-BET151 (GSK1210151A)

    7-(3,5-二甲基异噁唑-4-基)-8-甲氧基-1-((R)-1-(吡啶-2-基)乙基)-1H-咪唑并[4,5-C]喹啉-2(3H)-酮,GSK1210151A

     A BRD2, BRD3, and BRD4 inhibitor
  22. GC17073 I-BET-762

    (4S)-6-(4-氯苯基)-N-乙基-8-甲氧基-1-甲基-4H-[1,2,4]三唑并[4,3-A][1,4]苯并二氮杂卓-4-乙酰胺,I-BET762; GSK525762; GSK525762A

     Inhibitor of BET proteins
  23. GC11537 MK-4827 tosylate

    尼拉帕尼对苯甲磺酸盐; MK-4827 tosylate

     An orally bioavailable PARP1/2 inhibitor
  24. GC12756 MK-4827 hydrochloride

    MK-4827 hydrochloride

     MK-4827 hydrochloride (MK-4827 hydrochloride) 是一种高效且具有口服生物利用度的 PARP1 和 PARP2 抑制剂，IC50 分别为 3.8 和 2.1 nM。 MK-4827 hydrochloride 抑制 DNA 损伤的修复，激活细胞凋亡并显示出抗肿瘤活性。
  25. GC11424 Valproic acid

    丙戊酸; VPA; 2-Propylpentanoic Acid

     A class I HDAC inhibitor
  26. GC16143 Varenicline Hydrochloride

    6,7,8,9-四氢-6,10-甲桥-6H-吡嗪并[2,3-H][3]苯并氮杂卓盐酸盐,CP 526555 hydrochloride

     Varenicline Hydrochloride (CP 526555 hydrochloride) 是一种高亲和力、选择性的 α4β2 尼古丁乙酰胆碱受体 (nAChR) 部分激动剂和完整的 α7 nAChR 激动剂。
  27. GC11439 MG 149

    Tip60 HAT inhibitor

     A HAT inhibitor
  28. GC12891 CCT007093

    (2E,5E)-2,5-二(2-噻吩基亚甲基)环戊酮

     An inhibitor of PPM1D
  29. GC14755 Inauhzin

    INZ

     A selective SIRT1 inhibitor
  30. GC14364 SGI-1027

    DNA Methyltransferase Inhibitor II

     A DNA methyltransferase inhibitor
  31. GC14676 Pacritinib (SB1518)

    帕克替尼

     An equipotent inhibitor of FLT3 and JAK2
  32. GC11375 UNC1999 A selective, cell-permeable EZH2 inhibitor
  33. GC14652 MM-102

    HMTase Inhibitor IX

     An inhibitor of WDR5/MLL interactions
  34. GC15603 JIB-04

    5-氯-2(1H)-吡啶酮(2E)-(苯基-2-吡啶基亚甲基)腙

     A pan Jumonji histone demethylase inhibitor
  35. GC14199 RVX-208

    阿帕他隆; RVX-208; RVX000222

     A selective BET bromodomain antagonist
  36. GC18096 UNC669 A selective MBT inhibitor
  37. GC13419 ME0328 A selective PARP3 inhibitor
  38. GC10442 MK-8745 An Aurora A kinase inhibitor
  39. GC17703 TMP269

    TMP 269;TMP-269

     A selective class IIa HDAC inhibitor
  40. GC14285 RGFP966

    RGFP 966;RGFP-966

     RGFP966是一种N-(o-aminophenyl)carboxamide HDAC抑制剂，对HDAC3的IC50为0.08 μM，是一类针对HDAC3的慢开/慢关竞争性紧密结合抑制剂。
  41. GC11548 Tankyrase Inhibitors (TNKS) 49

    TNKS 49;TNKS49;TNKS-49

     Tankyrase inhibitor
  42. GC15041 Tankyrase Inhibitors (TNKS) 22

    TNKS 22;TNKS22;TNKS-22

     Tankyrase inhibitor
  43. GC12337 Tenovin-3

    Tenovin 3;Tenovin3

     A small molecule activator of p53
  44. GC10322 Tubastatin A HCl

    TubastatinA盐酸盐,TSA HCl;Tubastatin A hydrochloride

     A potent HDAC6 inhibitor
  45. GC16436 Tenovin-6 A small molecule activator of p53
  46. GC12781 XAV-939

    3,5,7,8-四氢-2-[4-(三氟甲基)苯基]-4H-噻喃并[4,3-D]嘧啶-4-酮

     XAV-939 选择性抑制 β-连环蛋白介导的转录。
  47. GC10555 Splitomicin

    斯普利特麻一辛

     Inhibitor of yeast Sir2p
  48. GC17455 TAK-632 A selective pan-Raf inhibitor
  49. GC15718 CID 2011756 An inhibitor of protein kinase D
  50. GC14062 EPZ-6438

    E-7438,Tazemetostat

    EPZ-6438 是一种有效且具有生物利用度的 EZH2 抑制剂，EZH2 是多梳抑制复合物 2 (PRC2) 的催化亚基，可催化组蛋白 H3 (H3K27) 的赖氨酸 27 甲基化，从而抑制含有人 PRC2 的活性抑制常数 Ki 值为 2.5 nM 的野生型 EZH2。
  51. GC14562 Nanaomycin A

    七尾霉素,Nanafrocin, Nanafrocine, Nanafrocinum, Rosanomycin A

     A bacterial metabolite

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