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Home >> Signaling Pathways >> Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. 产品名称 Information
  2. GC14631 SP2509

    HCI-2509, LSD1 Inhibitor VII

     A reversible inhibitor of LSD1
  3. GC12557 ML324

    CID-44143209

     A cell-permeable inhibitor of JMJD2 demethylases
  4. GC11574 HPOB A potent and selective inhibitor of HDAC6
  5. GC12971 CAY10603

    BML-281

     An exceptionally potent inhibitor of HDAC6
  6. GC12189 LB-100 A PP2A inhibitor with anticancer activity
  7. GC10259 BRD4770

    HMTase Inhibitor VI

     An inhibitor of EHMT2/G9a
  8. GC10021 CPI-360 A selective EZH2 inhibitor
  9. GC11430 Remodelin Remodelin 是 N-乙酰转移酶 10 (NAT10) 的小分子抑制剂。
  10. GC17956 PFI-2

    (R)-PFI-2

     PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride 是一种有效的选择性 SET 结构域，含有赖氨酸甲基转移酶 7 (SETD7) 抑制剂。
  11. GC14439 Santacruzamate A (CAY10683)

    HDAC抑制剂,CAY-10683

     A histone deacetylase inhibitor
  12. GC16611 GW841819X

    BET bromodomain inhibitor
  13. GC11209 Cerdulatinib (PRT062070)

    赛度替尼,PRT062070; PRT2070

     A dual inhibitor of Syk and JAKs
  14. GC16741 UNC0379 A selective SET8 inhibitor
  15. GC13249 Rucaparib (free base)

    瑞卡帕布; AG014699; PF-01367338

     A PARP1 inhibitor
  16. GC11990 TCS-PIM-1-4a

    5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮,SMI-4a

     TCS-PIM-1-4a (SMI-4a) 是一种泛 Pim 激酶抑制剂，通过激活 AMPK 来阻断 mTORC1 的活性。 TCS-PIM-1-4a 可杀死多种髓系和淋巴系细胞系（IC50 值范围为 0.8 μM 至 40 μM）。
  17. GC17222 GLPG0634 analogue GLPG0634 类似物 (Compoun 176) 是一种广谱 JAK 抑制剂，对 JAK1、JAK2 和 JAK3 的 IC50 值 <100 nM。
  18. GC16314 TC-E 5001 TC-E 5001 是一种 Wnt 通路抑制剂，通过新的腺苷口袋结合抑制 tankyrase 1/2 (TNKS1/2)，Kd 分别为 79 nM 和 28 nM。 TC-E 5001 还抑制 Axin2 和 STF，IC50 分别为 0.709 μM 和 0.215 μM。
  19. GC10148 RN 1 dihydrochloride

    LSD1 Inhibitor IV

     An irreversible LSD1 inhibitor
  20. GC17118 GSK J5

    N-[2-(3-吡啶基)-6-(1,2,4,5-四氢-3H-3-苯并氮杂卓-3-基)-4-嘧啶基]-BETA-丙氨酸乙酯

     A negative control compound for GSK-J4
  21. GC13086 GSK J2

    N-[2-(3-吡啶基)-6-(1,2,4,5-四氢-3H-3-苯并氮杂卓-3-基)-4-嘧啶基]-BETA-丙氨酸

     A negative control compound for GSK-J1
  22. GC13187 I-BET 151 hydrochloride A BRD2, BRD3, and BRD4 inhibitor
  23. GC17754 IOX 1

    5-羰基-8-羟基喹啉

     A 2-oxoglutarate oxygenase inhibitor
  24. GC14249 UNC 0642

    2-(4,4-二氟-1-哌啶基)-6-甲氧基-N-[1-异丙基-4-哌啶基]-7-[3-(1-吡咯烷基)丙氧基]-4-喹唑啉胺

     A G9a histone methyltransferase inhibitor
  25. GC15731 L002

    p300/CBP Inhibitor VI, NSC 764414

     A p300 acetyltransferase inhibitor
  26. GC15104 (R)-(+)-Etomoxir sodium salt

    (R)-(+)-乙莫克舍钠盐,(R)-(+)-Etomoxir sodium salt

     (R)-(+)-Etomoxir sodium salt(Etomoxir; ETO)是一种用于代谢和心血管疾病的小分子,经酶转化为活性抑制剂乙托莫西里尔辅酶a (IC50 约为0.01-0.70 µM)后,对CPT-1a和CPT-1b的抑制表现出纳摩尔效价。
  27. GC14817 Salermide A sirtuin inhibitor
  28. GC17881 AGK 2

    2-氰基-3-[5-(2,5-二氯苯基)-2-呋喃基]-N-5-喹啉基-2-丙烯酰胺

     AGK2是一种选择性的SIRT2 抑制剂,IC50为3.5 µM。
  29. GC12934 YM 750 YM 750 是一种有效的 acyl-CoA:cholesterol acyltransferase (ACAT) 抑制剂 (IC50\u003d0.18 μM)。
  30. GC10931 VULM 1457 VULM 1457 是一种有效的胆固醇酰基转移酶 (acyl-CoA) 抑制剂。
  31. GC11539 CI 976

    CI 976

     An inhibitor of ACAT-1
  32. GC11561 NSC 95397

    Cdc25 Inhibitor IV, PTP Inhibitor XXIX

     An irreversible inhibitor of Cdc25 isoforms
  33. GC16130 C 21 Protein arginine methyltransferase 1 (PRMT1) inhibitor
  34. GC17672 TC-E 5003

    N,N'-[磺酰基二(4,1-亚苯基)]二(2-氯乙酰胺)

     A PRMT1 inhibitor
  35. GC14361 PFI 3

    (2E)-1-(2-羟基苯基)-3-[(1R,4R)-5-(2-吡啶基)-2,5-二氮杂双环[2.2.1]庚-2-基]-2-丙烯-1-酮

     Probe for bromodomains of SMARCA2/4 and PB1(bromodomain 5)
  36. GC11340 (R)-PFI 2 hydrochloride

    (R)-PFI-2 hydrochloride

     A SET7/9 inhibitor
  37. GC13919 Tranylcypromine hydrochloride

    反苯环丙胺盐酸盐,SKF 385 hydrochloride

     An irreversible, mechanism-based inhibitor of LSD1
  38. GC11381 Tautomycetin

    Tautomycetin 是一种有效的特异性 PP1 抑制剂，具有潜在的细胞凋亡诱导活性。
  39. GC12359 Hispidulin

    高车前素; Dinatin

     A flavonoid with diverse biological activities
  40. GC14875 NSC 663284

    DA-3003-1

     Inhibitor of Cdc25 isoforms
  41. GC10676 AK-7

    N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺

     An inhibitor of SIRT2
  42. GC16599 CPI-169 A selective EZH2 inhibitor
  43. GC13926 BMS-345541(free base) BMS-345541(free base) 是 IKK 催化亚基的选择性抑制剂 (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM)。 BMS-345541（游离碱）结合在 IKK 的变构位点。
  44. GC12667 4SC-202

    4SC-202(盐的形式),4SC-202

     An HDAC1-3 and KDM1A inhibitor
  45. GC13764 Nexturastat A A potent, cell-permeable HDAC6 inhibitor
  46. GC12917 Acetaminophen

    对乙酰氨基酚; Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide

    An analgesic and antipyretic compound
  47. GC10243 Nanaomycin C

    七尾霉素C

    Amide of nanaomycin A
  48. GC14066 Procaine

    普鲁卡因

     An Analytical Reference Standard
  49. GC17052 MK-4827 Racemate selective inhibitor of PARP1/PARP2
  50. GC11767 Hydralazine HCl

    盐酸肼屈嗪

     An antihypertensive agent
  51. GC15857 Sodium butyrate

    丁酸钠

     A short-chain fatty acid and HDAC inhibitor

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