Stem Cell(干细胞)

Cat.No. 产品名称 Information

GC36483 L-Quebrachitol L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.

GC36362 Jagged-1 188-204 Jagged-1 (188-204) 是 JAG-1 蛋白的一个片段。JAG-1 是一种在培养的和原发性多发性骨髓瘤 (MM) 细胞中高度表达的 Notch 配体。JAG-1 诱导单核细胞衍生的人树突状细胞成熟。

GC36361 Jagged-1 (188-204) TFA Jagged-1 (JAG-1) 蛋白片段

GC36313 Indirubin-5-sulfonate Indirubin-5-sulfonate 是周期蛋白依赖性激酶(CDK) 的抑制剂，对CDK1/cyclin B、CDK2/cyclin A、CDK2/cyclin E、CDK4/cyclin D1 和CDK5/p35 的IC50 值分别为55 nM、35 nM、150 nM、300 nM 和 65 nM。Indirubin-5-sulfonate 同样能抑制GSK-3β 的活性。

GC36312 Indirubin-3'-monoxime-5-sulphonic acid Indirubin-3'-monoxime-5-sulphonic acid 是一种有效选择性的 CDK1，CDK5，GSK-3β 抑制剂，对应的 IC50 值分别为 5 nM，7 nM，80 nM。

GC36304 IMR-1A IMR-1A, an acid metabolite of IMR-1, is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. IMR-1A exhibits anti-tumor activity.

GC36193 GSK-3β inhibitor 1 GSK-3β inhibitor 1 (compound 3a) 是糖原合成酶激酶 3β (GSK-3β)的抑制剂，具有治疗糖尿病的潜能，其对 GSK-3β 的 IC50 值为 4.9 nM。

GC36190 GSK-3 inhibitor 1 GSK-3 inhibitor 1 是 GSK-3 抑制剂。

GC36073 Foxy-5 A Wnt5a peptide mimetic

GC35873 DK419 DK419 是一种有效、可口服的 Wnt/β-catenin 信号通路抑制剂，IC50 值为 0.19 μM。DK419 能降低 Axin2，β-catenin，c-Myc，Cyclin D1 和 Survivin 能够改变细胞内耗氧率，诱导 pAMPK 的产生。

GC35612 Carvacrol A monoterpene with diverse biological activities

GC35559 Bruceine D Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.

GC35537 BMS-983970 BMS-983970是Notch口服性抑制剂，用于抗癌研究。

GC35535 BMS-906024 BMS-906024 是一种口服有效，选择性的 γ 分泌酶 (gamma secretase) 抑制剂 (GSI)，GSIs 是一类小分子 Notch 抑制剂。BMS-906024 可阻止具有高口服生物利用度的所有四种 Notch 受体的激活，对于 Notch1，-2，-3 和 -4 受体，IC50s 分别为 1.6，0.7，3.4 和 2.9 nM。 BMS-906024 表现出针对多种人癌症异种移植物的广谱抗肿瘤活性。

GC35162 5-Iodo-indirubin-3'-monoxime 5-Iodo-indirubin-3'-monoxime 是一种有效的 GSK-3β，CDK5/P25 和 CDK1/cyclin B 抑制剂，与 ATP 竞争性地结合酶的催化位点，IC50 值分别为 9，20 和 25 nM。

GC34980 (E)-Ferulic acid Trans-ferulic acid is a potent activator of AMPKunder high glucose condition.

GC45137 Valproic Acid Acyl-D-Glucuronide A metabolite of valproic acid

GC45090 Triparanol An inhibitor of DHCR24

GC44855 RU-SKI 43 (hydrochloride) An inhibitor of hedgehog acyltransferase

GC44851 Rosiglitazone (potassium salt) A PPARγ agonist

GC44612 PF-4800567 A selective CK1ε inhibitor

GC44467 NSC 668036 An inhibitor of the Dvl PDZ domain

GC44458 N-Palmitoyl-L-Aspartate A natural N-acylaspartate

GC44321 Nat-20(S)-yne Nat-20(S)-OHC with a terminal alkyne group

GC44250 MS351

MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain.

GC44245 MoTP A tool for ablating zebrafish larval melanocytes

GC44213 ML115 A cell-permeable STAT3 activator

GC44080 LLP-3 Induces apoptosis by blocking Survivin/Ran interactions

GC43873 Hydrocortisone 21-hemisuccinate (sodium salt) A derivative of cortisol

GC43809 Hedgehog Antagonist VIII An inhibitor of hedgehog pathway signaling

GC43734 Ganglioside GQ1b Mixture (sodium salt)

A mixture of ganglioside G_Q1b

GC43729 Ganglioside GD3 Mixture (sodium salt) A mixture of ganglioside G_D3

GC43725 Gallocyanine A Dkk1 inhibitor

GC43618 Epiblastin A An inhibitor of CK1α, CK1δ, and CK1ε

GC43462 Dihydrolipoic Acid A reduced form of α-lipoic acid

GC43346 Cyclopamine-KAAD A potent inhibitor of hedgehog signaling

GC42944 BIX01294 (hydrochloride hydrate) An inhibitor of G9a histone methyltransferase

GC42669 ABC99 An inhibitor of NOTUM

GC41719 (R)-nitro-Blebbistatin A more stable form of (+)-blebbistatin

GC41587 cis-Vaccenic Acid An ω-7 fatty acid

GC41534 FzM1 An allosteric ligand of Frizzled4

GC41468 Retreversine An inactive isomer of reversine

GC40571 24(S),25-epoxy Cholesterol An oxysterol

GC34818 Super-TDU 1-31 Super-TDU(1-31)是Super-TDU的多肽片段。Super-TDU为YAP-TEADs相互作用抑制剂，具有抗肿瘤活性。

GC34650 Longdaysin

Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7.

GC34635 JI051 JI051是一种Hes1-PHB2相互作用稳定剂，能够与癌症相关蛋白伴侣prohibitin2(PHB2)相互作用，通过抑制Notch下游效应基因Hes1来诱导细胞周期停滞。具有抗肿瘤作用。

GC34628 IWP-O1 IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.

GC34536 CK1-IN-1 CK1-IN-1 (PUN51207, Compound 1C) is an inhibitor of casein kinase 1 (CK1) with IC50 of 15 nM, 16 nM and 73 nM for CK1δ, CK1ε and p38α MAPK, respectively.

GC34463 ALLO-2 ALLO-2 is potent antagonist of both wild-type mouse Smo and drug-resistant D473H mutant human Smo that inhibits Smo agonist inhibited Gli-Luc activity in TM3-Gli-Luc cells with IC50 of 6 nM.

GC34356 Casein Kinase II Inhibitor IV Hydrochloride CaseinKinaseIIInhibitorIVHydrochloride是表皮角质形成细胞分化的小分子诱导剂。