Hedgehog

Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.

Cat.No. 产品名称 Information
GC66390 3-epi-Vitamin D3
GC64134 Hh-Ag1.5
GC49651 19-alkyne Cholesterol An alkyne derivative of cholesterol for click chemistry
GC47570 Lipoxygenin An inhibitor of 5-LO
GC47474 Itraconazole-d5 An internal standard for the quantification of itraconazole
GC47435 HPI-1 (hydrate) A Hedgehog pathway inhibitor
GC39359 Ciliobrevin D Ciliobrevin D (compound 5) is a cell-permeable, reversible and specific antagonist of AAA+ (ATPases associated with diverse cellular activities) ATPase motor cytoplasmic dynein. Ciliobrevin D perturbs primary cilia formation and blocks Hedgehog (Hh) signaling.
GC37573 RU-SKI 43 An inhibitor of hedgehog acyltransferase
GC45090 Triparanol An inhibitor of DHCR24
GC44855 RU-SKI 43 (hydrochloride) An inhibitor of hedgehog acyltransferase
GC44458 N-Palmitoyl-L-Aspartate A natural N-acylaspartate
GC44321 Nat-20(S)-yne Nat-20(S)-OHC with a terminal alkyne group
GC43809 Hedgehog Antagonist VIII An inhibitor of hedgehog pathway signaling
GC43346 Cyclopamine-KAAD A potent inhibitor of hedgehog signaling
GC18475 Robotnikinin A direct inhibitor of sonic hedgehog
GC11217 CUR 61414 A potent inhibitor of hedgehog-induced activity
GC17713 Oxy-16 A synthetic oxysterol
GC13630 MK-4101 A Smoothened receptor antagonist
GC12068 SAG An agonist of Smoothened
GC15422 20(S)-Hydroxycholesterol An allosteric Smo agonist
GC15284 U 18666A A potent inhibitor of intracellular cholesterol transport
GC15889 SANT-1 An antagonist of Smoothened
GC12429 AY 9944 dihydrochloride A cholesterol synthesis inhibitor
GC14715 AZ 12080282 dihydrochloride 刺猬抑制剂
GC11111 Jervine An inhibitor of the hedgehog signaling pathway
GC11476 Ciliobrevin A A hedgehog pathway inhibitor
GC11045 HPI 1 A Hedgehog pathway inhibitor
GC11193 SANT-2 A Smoothened receptor antagonist
GC15256 JK 184 An inhibitor of downstream hedgehog signaling
GC15683 LY2940680 A Smo antagonist
GC17153 CHIR-99021 (CT99021) HCl A selective GSK3 inhibitor
GC13280 PF-5274857 PF-5274857 是一种有效的、选择性的、具有口服活性的脑渗透性 Smo 拮抗剂，IC50 为 5.8 nM，Ki 为 4.6 nM。 PF-5274857 具有研究肿瘤类型的潜力，包括由激活的 Hh 通路驱动的脑肿瘤和脑转移。
GC13441 Cyclopamine An inhibitor of hedgehog signaling
GC10359 GANT61 Antagonist of Gli transcription factors, involved in Hedgehog signaling
GC15064 Purmorphamine A small molecule Smo receptor agonist
GC16789 GANT 58 An inhibitor of Gli transcription
GC10493 GDC-0449 (Vismodegib) GDC-0449 (Vismodegib) (GDC-0449) 是一种具有口服活性的hedgehog 通路抑制剂，IC50 为3 nM。 GDC-0449 (Vismodegib) 还抑制 P-gp、ABCG2，IC50 值分别为 3.0 μM 和 1.4 μM。