Hedgehog
Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.
- Cat.No. 产品名称 Information
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GC66390
3-epi-Vitamin D3
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4) 是维生素 D3 类似物,是一种 Hedgehog pathway 抑制剂,在U87MG 细胞中测定的 IC50 为 39.2 μM。
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GC64134
Hh-Ag1.5
Hh-Ag1.5 (SAg1.5) 是一种有效的 Hedgehog (Hh) 激动剂,EC50 为 1 nM。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态,从而挽救了肝衰竭。
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GC49651
19-alkyne Cholesterol
An alkyne derivative of cholesterol for click chemistry
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GC47570
Lipoxygenin
An inhibitor of 5-LO
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GC47474
Itraconazole-d5
An internal standard for the quantification of itraconazole
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GC47435
HPI-1 (hydrate)
A Hedgehog pathway inhibitor
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GC39359
Ciliobrevin D
Ciliobrevin D (compound 5) is a cell-permeable, reversible and specific antagonist of AAA+ (ATPases associated with diverse cellular activities) ATPase motor cytoplasmic dynein. Ciliobrevin D perturbs primary cilia formation and blocks Hedgehog (Hh) signaling.
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GC37573
RU-SKI 43
An inhibitor of hedgehog acyltransferase
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GC45090
Triparanol
An inhibitor of DHCR24
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GC44855
RU-SKI 43 (hydrochloride)
An inhibitor of hedgehog acyltransferase
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GC44458
N-Palmitoyl-L-Aspartate
A natural N-acylaspartate
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GC44321
Nat-20(S)-yne
Nat-20(S)-OHC with a terminal alkyne group
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GC43809
Hedgehog Antagonist VIII
An inhibitor of hedgehog pathway signaling
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GC43346
Cyclopamine-KAAD
A potent inhibitor of hedgehog signaling
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GC18475
Robotnikinin
A direct inhibitor of sonic hedgehog
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GC11217
CUR 61414
A potent inhibitor of hedgehog-induced activity
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GC17713
Oxy-16
A synthetic oxysterol
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GC13630
MK-4101
A Smoothened receptor antagonist
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GC12068
SAG
An agonist of Smoothened
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GC15422
20(S)-Hydroxycholesterol
An allosteric Smo agonist
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GC15284
U 18666A
A potent inhibitor of intracellular cholesterol transport
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GC15889
SANT-1
An antagonist of Smoothened
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GC12429
AY 9944 dihydrochloride
A cholesterol synthesis inhibitor
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GC14715
AZ 12080282 dihydrochloride
刺猬抑制剂
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GC11111
Jervine
An inhibitor of the hedgehog signaling pathway
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GC11476
Ciliobrevin A
A hedgehog pathway inhibitor
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GC11045
HPI 1
A Hedgehog pathway inhibitor
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GC11193
SANT-2
A Smoothened receptor antagonist
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GC15256
JK 184
An inhibitor of downstream hedgehog signaling
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GC15683
LY2940680
A Smo antagonist
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GC17153
CHIR-99021 (CT99021) HCl
A selective GSK3 inhibitor
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GC13280
PF-5274857
PF-5274857 是一种有效的、选择性的、具有口服活性的脑渗透性 Smo 拮抗剂,IC50 为 5.8 nM,Ki 为 4.6 nM。 PF-5274857 具有研究肿瘤类型的潜力,包括由激活的 Hh 通路驱动的脑肿瘤和脑转移。
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GC13441
Cyclopamine
An inhibitor of hedgehog signaling
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GC10359
GANT61
Antagonist of Gli transcription factors, involved in Hedgehog signaling
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GC15064
Purmorphamine
Purmorphamine is the first small molecule agonist developed for Smoothened protein.
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GC16789
GANT 58
An inhibitor of Gli transcription
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GC10493
GDC-0449 (Vismodegib)
GDC-0449 (Vismodegib) (GDC-0449) 是一种具有口服活性的hedgehog 通路抑制剂,IC50 为3 nM。 GDC-0449 (Vismodegib) 还抑制 P-gp、ABCG2,IC50 值分别为 3.0 μM 和 1.4 μM。