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Smoothened is a G protein-coupled receptor of the hedgehog signaling pathway.

  1. Cat.No. 产品名称 Information
  2. GC64419 MRT-14
  3. GC63863 MRT-83 hydrochloride
  4. GC63336 MRT-81 MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells, exerting potent hedgehog (Hh) signaling pathway inhibiting activity.
  5. GC62258 SAG-d3
  6. GC50685 Dynapyrazole A Dynein inhibitor
  7. GC50486 Dynarrestin A dynein inhibitor
  8. GC50203 IHR-Cy3 IHR-Cy3 是一种有效的荧光 Smo 拮抗剂,IC50 为 100 nM。
  9. GC50135 SAG 21k Hedgehog signaling activator; brain penetrant and orally bioavailable
  10. GC37580 SAG hydrochloride Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
  11. GC34463 ALLO-2 ALLO-2 is potent antagonist of both wild-type mouse Smo and drug-resistant D473H mutant human Smo that inhibits Smo agonist inhibited Gli-Luc activity in TM3-Gli-Luc cells with IC50 of 6 nM.
  12. GC33114 MRT-83
  13. GC32978 Saridegib (IPI-926)
  14. GC32954 LEQ506 (NVP-LEQ506)
  15. GC18599 PF-05274857 (hydrochloride) PF-05274857 (hydrochloride) 是一种有效的、选择性的、具有口服活性的脑渗透性 Smo 拮抗剂,IC50 为 5.8 nM,Ki 为 4.6 nM。 PF-05274857(盐酸盐)具有研究肿瘤类型的潜力,包括由激活的 Hh 通路驱动的脑肿瘤和脑转移。
  16. GC11217 CUR 61414 A potent inhibitor of hedgehog-induced activity
  17. GC14749 ALLO-1 A smoothened antagonist
  18. GC13630 MK-4101 A Smoothened receptor antagonist
  19. GC12068 SAG An agonist of Smoothened
  20. GC14640 GSA 10 An agonist of Smoothened
  21. GC13041 M 25 Smoothened (Smo) receptor antagonist
  22. GC12228 SMANT hydrochloride Smoothened (Smo) signaling inhibitor
  23. GC12192 MRT 10 An antagonist of the Smo receptor
  24. GC15422 20(S)-Hydroxycholesterol An allosteric Smo agonist
  25. GC14896 Halcinonide A synthetic glucocorticoid
  26. GC13655 LDE225 (NVP-LDE225,Erismodegib) LDE225 (NVP-LDE225,Erismodegib) (Erismodegib) 是一种有效的选择性 Smo 拮抗剂,在结合试验中对小鼠和人 Smo 的 IC50 分别为 1.3 nM 和 2.5 nM。
  27. GC16230 PF-04449913 A Smo antagonist
  28. GC15889 SANT-1 An antagonist of Smoothened
  29. GC11111 Jervine An inhibitor of the hedgehog signaling pathway
  30. GC15683 LY2940680 A Smo antagonist
  31. GC13280 PF-5274857 PF-5274857 是一种有效的、选择性的、具有口服活性的脑渗透性 Smo 拮抗剂,IC50 为 5.8 nM,Ki 为 4.6 nM。 PF-5274857 具有研究肿瘤类型的潜力,包括由激活的 Hh 通路驱动的脑肿瘤和脑转移。
  32. GC15064 Purmorphamine A small molecule Smo receptor agonist
  33. GC14169 LDE225 Diphosphate A Smo antagonist
  34. GC12951 HhAntag A hedgehog pathway inhibitor
  35. GC13628 BMS-833923 An orally bioavailable Smo inhibitor

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