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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling(PI3K/Akt/mTOR 信号传导)

  1. Cat.No. 产品名称 Information
  2. GC17658 Guggulsterone Guggulsterone 是一种植物甾醇，来自于 Commiphora wightii 的树胶树脂。 Guggulsterone 通过下调抗凋亡基因产物（IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP 和 survivin），调节细胞周期蛋白（cyclin D1 和c-Myc)，激活半胱天冬酶和 JNK，抑制 Akt。 Guggulsterone 是一种法尼醇 X 受体 (FXR) 拮抗剂，可降低 CDCA 诱导的 FXR 活化，对 Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。
  3. GC12661 Indirubin-3'-oxime Inhibitor of GSK3β and cyclin-dependent kinases
  4. GC10070 CGS 15943 A potent adenosine receptor antagonist
  5. GC12532 CHPG A potent and selective mGluR5 agonist
  6. GC16157 740 Y-P

    PI 3-激酶活化剂，可穿透细胞膜。
  7. GC12364 SAMS Peptide A specific substrate for AMPK
  8. GC14182 Kenpaullone A inhibitor of cyclin-dependent kinase and GSK3β
  9. GC12078 3CAI An inhibitor of Akt1 and Akt2
  10. GC15310 PI-3065 A potent, selective inhibitor of p110δ
  11. GC17712 AT13148 A multi-AGC kinase inhibitor
  12. GC13907 1-Azakenpaullone A potent inhibitor of GSK3β
  13. GC12975 Indirubin A natural inhibitor of GSK3 and CDK isoforms
  14. GC17330 (+)-Usniacin (+)-Usniacin 从地衣中分离出来，结合在 mTOR 的 ATP 结合口袋，并抑制 mTORC1/2 活性。 (+)-Usniacin 抑制 mTOR 下游效应子的磷酸化:Akt (Ser473)、4EBP1、S6K，诱导自噬，具有抗癌活性。 (+)-Usniacin 对许多浮游革兰氏阳性菌具有抗菌活性，包括金黄色葡萄球菌、粪肠球菌和粪肠球菌。
  15. GC12305 GSK2141795 A selective Akt inhibitor
  16. GC14318 CAY10505 Inhibitor of PI3Kγ
  17. GC13466 Flufenamic acid An NSAID and COX inhibitor
  18. GC10583 WAY-600 An mTOR inhibitor
  19. GC16231 TG100713 An inhibitor of PI3K
  20. GC13612 PIK-294 A potent inhibitor of p110δ
  21. GC15982 PIK-293 A selective inhibitor of p110δ
  22. GC10811 Miltefosine An inhibitor of CCT
  23. GC14987 GSK-3 Inhibitor IX (BIO) A potent, selective, and reversible GSK3 inhibitor
  24. GC12080 AS-604850 A selective inhibitor of PI3Kγ
  25. GC13901 AS-252424 A potent, selective inhibitor of PI3-kinase γ
  26. GC13071 Ridaforolimus (Deforolimus, MK-8669) A rapamycin analog that selectively inhibits mTOR in mTORC1
  27. GC17443 Metformin HCl

    A biguanide with diverse biological activities
  28. GC10461 Phenformin HCl An antihyperglycemic biguanide
  29. GC12982 BIX 02565 A RSK2 inhibitor with multiple off target effects
  30. GC10689 PF-4708671

    A specific, cell-permeable inhibitor of S6K1
  31. GC12155 OTSSP167 hydrochloride A potent inhibitor of MELK
  32. GC10201 OTSSP167 A potent inhibitor of MELK
  33. GC11868 CH5132799 An inhibitor of class I PI3K isoforms
  34. GC17766 BAY 80-6946 (Copanlisib) A selective PI3K inhibitor
  35. GC13321 WYE-687 An mTOR inhibitor
  36. GC17109 GSK2636771

    A selective inhibitor of PI3K p110β
  37. GC12275 GSK2334470 A selective PDK1 inhibitor
  38. GC14465 Tideglusib A neuroactive thiadiazolidinone
  39. GC10956 Imeglimin hydrochloride Imeglimin hydrochloride (EMD 387008) 是一种口服降糖剂。
  40. GC10576 Imeglimin Imeglimin (EMD 387008) 是一种口服降糖剂。
  41. GC17967 GDC-0032 A potent PI3K inhibitor that is β-sparing
  42. GC16568 AZD1080 A potent inhibitor of GSK3α and GSK3β
  43. GC10580 AICAR phosphate

    An activator of AMPK
  44. GC11177 GDC-0980 (RG7422) A dual inhibitor of PI3K and mTOR
  45. GC10982 YM201636 Inhibitor of PIKfyve
  46. GC13858 Torin 2 Selective inhibitor of mTOR
  47. GC12415 Rigosertib Rigosertib (ON-01910) 是一种多激酶抑制剂和选择性抗癌剂，通过抑制 PI3 激酶/Akt 通路诱导细胞凋亡，促进组蛋白 H2AX 的磷酸化并诱导细胞周期 G2/M 停滞。 Rigosertib 是一种选择性和非 ATP 竞争性的 PLK1 抑制剂，IC50 为 9 nM。
  48. GC13580 Rigosertib sodium Rigosertib sodium (ON-01910 sodium) 是一种多激酶抑制剂和选择性抗癌剂，通过抑制 PI3K/Akt 通路诱导细胞凋亡，促进组蛋白 H2AX 的磷酸化并诱导细胞周期 G2/M 停滞。 Rigosertib sodium 是一种选择性和非 ATP 竞争性的 PLK1 抑制剂，IC50 为 9 nM。
  49. GC11018 GSK1059615 A potent PI3K inhibitor
  50. GC14840 TDZD-8 A selective inhibitor of GSK3β
  51. GC15653 PF-05212384 (PKI-587) A potent, dual PI3K/mTOR inhibitor

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