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PIKfyve(含FYVE指磷酸肌醇激酶)

PIKfyve (1-phosphatidylinositol 3-phosphate 5-kinase) catalyzes the production of PtdIns5P and PtdIns(3,5)biphosphate from the phosphorylation o f D-5 position in PtdIns and phosphatidylinositol-3-phosphate. It is involved in endosome carrier vesicle biogenesis in early endosomes and endomembrane homeostasis.

  1. Cat.No. 产品名称 Information
  2. GC66013 MOMIPP MOMIPP,一种巨胞饮作用的诱导剂,是一种 PIKfyve 抑制剂。MOMIPP 可穿过血脑屏障 (BBB)。
  3. GC31661 APY0201 APY0201是一种有效的PIKfyve抑制剂,抑制PtdIns3P转化为PtdIns(3,5)P2,IC50为5.2nM。APY0201还抑制IL-12/IL-23产生。
  4. GC10982 YM201636 YM201636 是一种有效的选择性 PIKfyve 抑制剂,IC50 为 33 nM。

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