PI3K/Akt/mTOR Signaling(PI3K/Akt/mTOR 信号传导)

Cat.No. 产品名称 Information

GC31411 EX229 An AMPK activator

GC31383 Chitosan oligosaccharide COS Chitosan oligosaccharide (COS) is an oligomer of β-(1?4)-linked d-glucosamine, of which actions involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) and the activation of AMP-activated protein kinase (AMPK).

GC31361 MK-3903 An AMPK activator

GC31348 7-Methoxyisoflavone A synthetic isoflavone

GC30884 LX2343 An inhibitor of BACE1 and PI3K

GC30777 PI4KIIIbeta-IN-10 PI4KIIIbeta-IN-10是一种有效的PI4KIIIβ抑制剂，IC50为3.6nM。

GC30770 LM22B-10 An activator of TrkB and TrkC

GC30582 Crosstide A peptide substrate for Akt

GC30229 Cbz-B3A Cbz-B3A是mTORC1转导的有效选择性抑制剂，与泛素1、2、4结合，Cbz-B3A还能抑制eIF4E结合蛋白的磷酸化。

GC30156 Brevianamide F (Cyclo(L-Pro-L-Trp)) An alkaloid with diverse biological activities

GC30056 Danthron (Dantron) Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.

GC19471 Leniolisib An inhibitor of PI3Kδ

GC19411 IITZ-01 IITZ-01 是一种有效的溶酶体自噬抑制剂，具有单剂抗肿瘤活性，对 PI3Kγ 的 IC50 为 2.62 μM。

GC19390 YU238259 An inhibitor of homology-dependent DNA repair

GC19355 Umbralisib A PI3K p110δ inhibitor

GC19328 SF2523 A dual inhibitor of PI3K and BRD4

GC19300 PQR309 A pan inhibitor of PI3Ks and an inhibitor of mTOR

GC19286 PF-06409577 An AMPK activator

GC19283 PF-04979064 PF-04979064 是一种有效的选择性 PI3K/mTOR 双激酶抑制剂，对 PI3Kα 和 mTOR 的 Kis 分别为 0.13 nM 和 1.42 nM。

GC19269 O-304 A pan-activator of AMPK

GC19256 MTX-211 MTX-211 (Mol 211) 是 EGFR 和 PI3K 的双重抑制剂，IC50 值 <100 nM。 MTX-211可用于癌症和其他疾病的研究。

GC19227 LTURM34 An inhibitor of DNA-PK

GC19202 IPI549 An inhibitor of PI3Kγ

GC19161 GDC-0326 A selective inhibitor of PI3Kα

GC19145 ETP-46321 ETP-46321 是一种有效且具有口服生物利用度的 PI3Kα 和 PI3Kδ 抑制剂，Kiapps 分别为 2.3 和 14.2 nM。

GC19114 CZ415 An mTOR inhibitor

GC19109 CNX-1351 A PI3Kα inhibitor

GC19036 ARQ-092 An orally bioavailable pan-Akt inhibitor

GC18884 CAY10626 A dual PI3Kα/mTOR kinase inhibitor

GC18852 S14161 An inhibitor of cyclin D transactivation

GC18810 GSK3β Inhibitor XI A potent inhibitor of GSK3β

GC18583 D-α-Hydroxyglutaric Acid

An α-hydroxy acid

GC18479 SAR260301 A selective PI3Kβ inhibitor

GC18374 API-1 An Akt inhibitor

GC18322 CAY10567 An Akt1 translocation inhibitor

GC18208 YLF-466D An AMPK activator

GC18164 UCB9608 UCB9608 是一种有效、选择性和口服活性的 PI4KIIIβ 抑制剂，IC50 为 11 nM，对 PI3KC2 α、β 和 γ 脂质激酶具有选择性。

GC11607 Rapalink-1 第三代二价 mTOR 抑制剂 RapaLink-1 通过惰性化学接头将雷帕霉素与 MLN0128 结合。 RapaLink-1 显示出比雷帕霉素或 mTOR 激酶抑制剂 (TORKi) 更好的功效，可有效阻断癌症衍生的激活 mTOR 突变体。 RapaLink-1 可以穿过血脑屏障。 RapaLink-1 与 FKBP12 的结合导致 mTORC1 的靶向和持久抑制。 RapaLink-1 通过改善自噬在抗磷脂综合征中发挥抗血栓作用。抗癌活性。