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PDK-1 (3-phosphoinositide dependent protein kinase-1) is a master kinase, which is crucial for the activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK.

  1. Cat.No. 产品名称 Information
  2. GC69714 PKD-IN-1 dihydrochloride PKD-IN-1 dihydrochloride (化合物 32) 是一种氨基乙胺芳基 (AEAA) 化合物,可作为 PKD-1 抑制剂。PKD-IN-1 可用于蛋白激酶 D (PKD) 介导的疾病研究。
  3. GC66474 PDK1-IN-RS2 PDK1-IN-RS2 是一种肽对接基序 (PIFtide) 的模拟物,也是一种底物选择性 PDK1 抑制剂,Kd 为 9 μM。PDK1-IN-RS2 抑制 PDK1 对下游激酶 S6K1 的激活。
  4. GC63802 (R)-PS210 (R)-PS210 是 PS210 的 R 对映异构体 (化合物 4h-eutomer),是 PDK1 的底物选择性变构激活剂,AC50 值为 1.8 μM。(R)-PS210 靶向 PDK1 的 PIF 结合口袋。PIF: 蛋白激酶 C 相关激酶 2 (PRK2) 相互作用片段。
  5. GC63155 PS47 PS47 is an inactive E isomer of PS48, an activator of 3-Phosphoinositide-dependent protein kinase 1 (PDPK1).
  6. GC10857 UCN-01 A nonspecific protein kinase inhibitor
  7. GC15615 BX517(PDK1 inhibitor2) An inhibitor of PDK1
  8. GC13920 PS 48 PDK1激活剂
  9. GC12275 GSK2334470 A selective PDK1 inhibitor
  10. GC16818 BX-912 A potent inhibitor of PDK1
  11. GC15742 OSU-03012 (AR-12) An anti-cancer celecoxib analog
  12. GC11573 BX795 A multi-kinase inhibitor
  13. GC12866 PDK1 inhibitor PDK1 inhibitor (PDK1 inhibitor) 是一种磷酸肌醇依赖性激酶-1 (PDK1) 抑制剂。
  14. GC13725 NVP-BAG956 A dual PDK1 and class I PI3K inhibitor
  15. GN10709 Polyphyllin A A steroid saponin with anticancer activity

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