DNA-PK(DNA依赖蛋白激酶)

DNA-PK is a serine/threonine kinase and acts a molecular sensor for DNA damage. It is involved in NHEJ (non-homologous end joining) for DSB (DNA double strand break) repair and V(D)J recombination.

Products for DNA-PK

Cat.No. 产品名称 Information
GC65249 STL127705 STL127705 (Compound L) 是一种有效的 Ku 70/80 异二聚体蛋白 Ku 70/80 heterodimer protein 抑制剂，IC50 为 3.5 μM。STL127705 通过抑制 DNA-PKCS 激酶的激活干扰 Ku70/80 与 DNA 的结合。STL127705 显示出抗增殖和抗肿瘤活性。 STL127705 诱导细胞凋亡 (apoptosis) 。
GC64938 AZD-7648 An inhibitor of DNA-PK
GC64818 AMA-37 AMA-37 是Arylmorpholine 的类似物，是ATP 竞争性的DNA-PK 抑制剂，其IC50 值分别为0.27 μM (DNA-PK)、32 μM (p110α)、3.7 μM (p110β)、and 22 μM (p110γ)。
GC63763 BAY-8400 BAY-8400是一种口服活性、有效和选择性 DNA 依赖蛋白激酶 (DNA-PK) 抑制剂(IC50=81 nM)。BAY-8400 可用于癌症研究。
GC34749 Rac-Nedisertib Rac-Nedisertib(Rac-M3814)是Nedisertib的外消旋体，为有效的DNA-PK抑制剂，IC50值小于3nM。
GC34444 (R)-Nedisertib (R)-Nedisertib((R)-M3814)是一种活性较弱的Nedisertib的R型异构体，对DNA-PK的IC50值为7-30nM。
GC34121 CC-115 hydrochloride A dual inhibitor of mTOR and DNA-PK
GC33325 VX-984 (M9831)
M9831
VX-984 (M9831) (M9831) 是一种具有口服活性、强效、选择性和 BBB 穿透的 DNA-PK 抑制剂。 VX-984 (M9831) 有效抑制 NHEJ（非同源末端连接）并增加 DSB（DNA 双链断裂）。 VX-984 (M9831) 可用于胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSCLC) 研究。
GC32718 M3814 (nedisertib)
M3814
Nedisertib (M3814, Peposertib, MSC2490484A) is an orally bioavailable, highly potent and selective inhibitor of DNA activated protein kinase (DNA-PK) with IC50 of < 3 nM.
GC19390 YU238259 An inhibitor of homology-dependent DNA repair
GC19328 SF2523 A dual inhibitor of PI3K and BRD4
GC19227 LTURM34 An inhibitor of DNA-PK
GC16654 CC-115 A dual inhibitor of mTOR and DNA-PK
GC14371 LY3023414
LY3023414
LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
GC10812 Compound 401 A dual inhibitor of mTOR and DNA-PK
GC13858 Torin 2
9-(6-氨基-3-吡啶基)-1-[3-(三氟甲基)苯基]苯并[H]-1,6-萘啶-2(1H)-酮
Selective inhibitor of mTOR
GC12332 NU 7026
2-(4-吗啉基)-4H-萘并[1,2-B]吡喃-4-酮,LY293646
Inhibitor of DNA-dependent protein kinase
GC10196 ETP-46464
ATM Inhibitor III, ATR Inhibitor III
An ATR inhibitor
GC11251 NU7441 (KU-57788)
8-(4-二苯并噻吩基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮,KU 57788; NU-7441;KU57788;NU7441;NU 7441
A selective DNA-PK inhibitor
GC14346 KU-0060648 A dual inhibitor of DNA-PK and PI3K
GC16904 PIK-75
2-甲基-5-硝基苯磺酸[(6-溴咪唑并[1,2-A]吡啶-3-基)亚甲基]甲基肼盐酸盐
A selective p110α inhibitor
GC17199 PIK-90
N-(2,3-二氢-7,8-二甲氧基咪唑并[1,2-C]喹唑啉-5-基)-3-吡啶甲酰胺
Potent, cell permeable PI3K inhibitor
GC11165 PI-103 A potent, cell-permeable PI3-kinase inhibitor
GC15485 LY 294002
LY294002/PI3K抑制剂

LY294002是第一个合成的PI3Kα、δ和β抑制剂。
GC16379 PI-103 Hydrochloride
PI 103 hydrochloride;PI103 hydrochloride
A potent, cell-permeable PI3K inhibitor
GC11175 Daun02
(8S,10S)-8-乙酰基-7,8,9,10-四氢-6,8,11-三羟基-1-甲氧基-10-[[2,3,6-三脱氧-3-[[[[4-(BETA-D-吡喃半乳糖基氧基)-3-硝基苯基]甲氧基]羰基]氨基]-ALPHA-L-来苏-己糖吡喃糖苷]氧基]-5,12-并四苯醌,Daun 02; Daun-02
Daun02 是拓扑异构酶抑制剂柔红霉素的前药。