Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling >> DNA-PK


DNA-PK is a serine/threonine kinase and acts a molecular sensor for DNA damage. It is involved in NHEJ (non-homologous end joining) for DSB (DNA double strand break) repair and V(D)J recombination.

  1. Cat.No. 产品名称 Information
  2. GC65249 STL127705
  3. GC64938 AZD-7648 An inhibitor of DNA-PK
  4. GC64818 AMA-37
  5. GC63763 BAY-8400
  6. GC34749 Rac-Nedisertib
  7. GC34444 (R)-Nedisertib
  8. GC34121 CC-115 hydrochloride A dual inhibitor of mTOR and DNA-PK
  9. GC33325 VX-984 (M9831)
  10. GC32718 M3814 (nedisertib) Nedisertib (M3814, Peposertib, MSC2490484A) is an orally bioavailable, highly potent and selective inhibitor of DNA activated protein kinase (DNA-PK) with IC50 of < 3 nM.
  11. GC19390 YU238259 An inhibitor of homology-dependent DNA repair
  12. GC19328 SF2523 A dual inhibitor of PI3K and BRD4
  13. GC19227 LTURM34 An inhibitor of DNA-PK
  14. GC16654 CC-115 A dual inhibitor of mTOR and DNA-PK
  15. GC14371 LY3023414 LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
  16. GC10812 Compound 401 A dual inhibitor of mTOR and DNA-PK
  17. GC13858 Torin 2 Selective inhibitor of mTOR
  18. GC12332 NU 7026 Inhibitor of DNA-dependent protein kinase
  19. GC10196 ETP-46464 An ATR inhibitor
  20. GC11251 NU7441 (KU-57788) A selective DNA-PK inhibitor
  21. GC14346 KU-0060648 A dual inhibitor of DNA-PK and PI3K
  22. GC16904 PIK-75 A selective p110α inhibitor
  23. GC17199 PIK-90 Potent, cell permeable PI3K inhibitor
  24. GC11165 PI-103 A potent, cell-permeable PI3-kinase inhibitor
  25. GC15485 LY 294002

    A selective PI3K inhibitor

  26. GC16379 PI-103 Hydrochloride A potent, cell-permeable PI3K inhibitor
  27. GC11175 Daun02 Daun02 是拓扑异构酶抑制剂柔红霉素的前药。

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