DNA-PK(DNA依赖蛋白激酶)

DNA-PK is a serine/threonine kinase and acts a molecular sensor for DNA damage. It is involved in NHEJ (non-homologous end joining) for DSB (DNA double strand break) repair and V(D)J recombination.

Cat.No. 产品名称 Information
GC65249 STL127705
GC64938 AZD-7648 An inhibitor of DNA-PK
GC64818 AMA-37
GC63763 BAY-8400
GC34749 Rac-Nedisertib
GC34444 (R)-Nedisertib
GC34121 CC-115 hydrochloride A dual inhibitor of mTOR and DNA-PK
GC33325 VX-984 (M9831)
GC32718 M3814 (nedisertib) Nedisertib (M3814, Peposertib, MSC2490484A) is an orally bioavailable, highly potent and selective inhibitor of DNA activated protein kinase (DNA-PK) with IC50 of < 3 nM.
GC19390 YU238259 An inhibitor of homology-dependent DNA repair
GC19328 SF2523 A dual inhibitor of PI3K and BRD4
GC19227 LTURM34 An inhibitor of DNA-PK
GC16654 CC-115 A dual inhibitor of mTOR and DNA-PK
GC14371 LY3023414 LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
GC10812 Compound 401 A dual inhibitor of mTOR and DNA-PK
GC13858 Torin 2 Selective inhibitor of mTOR
GC12332 NU 7026 Inhibitor of DNA-dependent protein kinase
GC10196 ETP-46464 An ATR inhibitor
GC11251 NU7441 (KU-57788) A selective DNA-PK inhibitor
GC14346 KU-0060648 A dual inhibitor of DNA-PK and PI3K
GC16904 PIK-75 A selective p110α inhibitor
GC17199 PIK-90 Potent, cell permeable PI3K inhibitor
GC11165 PI-103 A potent, cell-permeable PI3-kinase inhibitor
GC15485 LY 294002
A selective PI3K inhibitor
GC16379 PI-103 Hydrochloride A potent, cell-permeable PI3K inhibitor
GC11175 Daun02 Daun02 是拓扑异构酶抑制剂柔红霉素的前药。