Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling >> mTOR


MTOR (mechanistic target of rapamycin) is a serine/threonine kinase that regulates cellular metabolism, growth ad survival. It mediates the cellular response to stress, growth factor and hormone etc. It is involved in cancer, aging and neurodegenerative diseases etc.

  1. Cat.No. 产品名称 Information
  2. GC66357 L-Leucine-d2
  3. GC65944 CC214-2
  4. GC65460 HDACs/mTOR Inhibitor 1
  5. GC65143 MKC-1
  6. GC65115 mTOR inhibitor-1 mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy.
  7. GC64402 MHY-1685 MHY-1685 is a novel mTOR inhibitor, which attenuates senescence by modulating autophagy through the inhibition of mTOR in human cardiac stem cells.
  8. GC64304 MTI-31 MTI-31 (LXI-15029) is a novel mTORC1/mTORC2 inhibitor with Kd of 0.2 nM in mTOR binding assays and displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G.
  9. GC64278 RP-3500 RP-3500 (Camonsertib, ATR inhibitor) is a highly potent and selective inhibitor of ATR kinase with an IC50 of 1 nM.
  10. GC64188 L-Leucine-d3
  11. GC63894 RMC-6272
  12. GC63833 L-Leucine-15N
  13. GC63524 (32-Carbonyl)-RMC-5552
  14. GC63122 NV-5138 hydrochloride A sestrin modulator and mTORC1 activator
  15. GC63121 NV-5138 A sestrin modulator and mTORC1 activator
  16. GC62649 RMC-5552
  17. GC62572 hSMG-1 inhibitor 11e
  18. GC62495 DS-7423
  19. GC62339 mTOR inhibitor-8
  20. GC62140 PKI-179 A dual PI3K and mTOR inhibitor
  21. GC61925 hSMG-1 inhibitor 11j
  22. GC48027 Rapamycin-d3 An internal standard for the quantification of rapamycin
  23. GC61336 TMBIM6 antagonist-1
  24. GC60258 MT 63-78
  25. GC39292 Rheb inhibitor NR1
  26. GC38609 Rotundic acid Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.
  27. GC38473 WYE-687 dihydrochloride An mTOR inhibitor
  28. GC38419 Cyclovirobuxine D An alkaloid with diverse biological activities
  29. GC38088 Hederacolchiside A1
  30. GC37922 Voxtalisib A dual inhibitor of PI3K and mTORC
  31. GC36909 PI3Kα/mTOR-IN-1
  32. GC35509 BGT226 BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.
  33. GC35395 Arnicolide D A sesquiterpene lactone with anticancer activity
  34. GC43585 eCF309 A selective mTOR inhibitor
  35. GC34909 JR-AB2-011 JR-AB2-011 is a potent inhibitor of mTOR-mLST8-mSIN1-Rictor complex (mTORC2) which can block mTORC2 signaling and Rictor association with mTOR at lower effective concentrations.
  36. GC34121 CC-115 hydrochloride A dual inhibitor of mTOR and DNA-PK
  37. GC33385 PQR-530 A dual inhibitor of PI3Kα and mTOR
  38. GC33355 FT-1518
  39. GC33115 Pomiferin (NSC 5113)
  40. GC33014 NSC781406 A dual inhibitor of PI3K and mTOR
  41. GC32891 PQR620 PQR620 is a novel, selective, orally bioavailable and brain penetrant dual TORC1/2 inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.
  42. GC32767 3BDO A butyrolactone derivative and autophagy inhibitor
  43. GC30229 Cbz-B3A
  44. GC19300 PQR309 A pan inhibitor of PI3Ks and an inhibitor of mTOR
  45. GC19283 PF-04979064 PF-04979064 是一种有效的选择性 PI3K/mTOR 双激酶抑制剂,对 PI3Kα 和 mTOR 的 Kis 分别为 0.13 nM 和 1.42 nM。
  46. GC19114 CZ415 An mTOR inhibitor
  47. GC18583 D-α-Hydroxyglutaric Acid An α-hydroxy acid
  48. GC11607 Rapalink-1 第三代二价 mTOR 抑制剂 RapaLink-1 通过惰性化学接头将雷帕霉素与 MLN0128 结合。 RapaLink-1 显示出比雷帕霉素或 mTOR 激酶抑制剂 (TORKi) 更好的功效,可有效阻断癌症衍生的激活 mTOR 突变体。 RapaLink-1 可以穿过血脑屏障。 RapaLink-1 与 FKBP12 的结合导致 mTORC1 的靶向和持久抑制。 RapaLink-1 通过改善自噬在抗磷脂综合征中发挥抗血栓作用。抗癌活性。
  49. GC10228 GDC-0084 PI3K and mTOR inhibitor, brain-permeable
  50. GC15740 OXA-01 A selective dual inhibitor of mTORC1 and mTORC2
  51. GC13648 CC-223 A potent, selective inhibitor of mTOR

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