mTOR
MTOR (mechanistic target of rapamycin) is a serine/threonine kinase that regulates cellular metabolism, growth ad survival. It mediates the cellular response to stress, growth factor and hormone etc. It is involved in cancer, aging and neurodegenerative diseases etc.
- Cat.No. 产品名称 Information
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GC66357
L-Leucine-d2
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GC65944
CC214-2
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GC65460
HDACs/mTOR Inhibitor 1
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GC65143
MKC-1
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GC65115
mTOR inhibitor-1
mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy.
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GC64402
MHY-1685
MHY-1685 is a novel mTOR inhibitor, which attenuates senescence by modulating autophagy through the inhibition of mTOR in human cardiac stem cells.
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GC64304
MTI-31
MTI-31 (LXI-15029) is a novel mTORC1/mTORC2 inhibitor with Kd of 0.2 nM in mTOR binding assays and displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G.
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GC64278
RP-3500
RP-3500 (Camonsertib, ATR inhibitor) is a highly potent and selective inhibitor of ATR kinase with an IC50 of 1 nM.
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GC64188
L-Leucine-d3
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GC63894
RMC-6272
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GC63833
L-Leucine-15N
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GC63524
(32-Carbonyl)-RMC-5552
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GC63122
NV-5138 hydrochloride
A sestrin modulator and mTORC1 activator
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GC63121
NV-5138
A sestrin modulator and mTORC1 activator
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GC62649
RMC-5552
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GC62572
hSMG-1 inhibitor 11e
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GC62495
DS-7423
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GC62339
mTOR inhibitor-8
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GC62140
PKI-179
A dual PI3K and mTOR inhibitor
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GC61925
hSMG-1 inhibitor 11j
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GC48027
Rapamycin-d3
An internal standard for the quantification of rapamycin
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GC61336
TMBIM6 antagonist-1
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GC60258
MT 63-78
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GC39292
Rheb inhibitor NR1
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GC38609
Rotundic acid
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.
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GC38473
WYE-687 dihydrochloride
An mTOR inhibitor
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GC38419
Cyclovirobuxine D
An alkaloid with diverse biological activities
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GC38088
Hederacolchiside A1
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GC37922
Voxtalisib
A dual inhibitor of PI3K and mTORC
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GC36909
PI3Kα/mTOR-IN-1
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GC35509
BGT226
BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.
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GC35395
Arnicolide D
A sesquiterpene lactone with anticancer activity
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GC43585
eCF309
A selective mTOR inhibitor
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GC34909
JR-AB2-011
JR-AB2-011 is a potent inhibitor of mTOR-mLST8-mSIN1-Rictor complex (mTORC2) which can block mTORC2 signaling and Rictor association with mTOR at lower effective concentrations.
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GC34121
CC-115 hydrochloride
A dual inhibitor of mTOR and DNA-PK
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GC33385
PQR-530
A dual inhibitor of PI3Kα and mTOR
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GC33355
FT-1518
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GC33115
Pomiferin (NSC 5113)
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GC33014
NSC781406
A dual inhibitor of PI3K and mTOR
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GC32891
PQR620
PQR620 is a novel, selective, orally bioavailable and brain penetrant dual TORC1/2 inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.
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GC32767
3BDO
A butyrolactone derivative and autophagy inhibitor
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GC30229
Cbz-B3A
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GC19300
PQR309
A pan inhibitor of PI3Ks and an inhibitor of mTOR
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GC19283
PF-04979064
PF-04979064 是一种有效的选择性 PI3K/mTOR 双激酶抑制剂,对 PI3Kα 和 mTOR 的 Kis 分别为 0.13 nM 和 1.42 nM。
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GC19114
CZ415
An mTOR inhibitor
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GC18583
D-α-Hydroxyglutaric Acid
An α-hydroxy acid
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GC11607
Rapalink-1
第三代二价 mTOR 抑制剂 RapaLink-1 通过惰性化学接头将雷帕霉素与 MLN0128 结合。 RapaLink-1 显示出比雷帕霉素或 mTOR 激酶抑制剂 (TORKi) 更好的功效,可有效阻断癌症衍生的激活 mTOR 突变体。 RapaLink-1 可以穿过血脑屏障。 RapaLink-1 与 FKBP12 的结合导致 mTORC1 的靶向和持久抑制。 RapaLink-1 通过改善自噬在抗磷脂综合征中发挥抗血栓作用。抗癌活性。
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GC10228
GDC-0084
PI3K and mTOR inhibitor, brain-permeable
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GC15740
OXA-01
A selective dual inhibitor of mTORC1 and mTORC2
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GC13648
CC-223
A potent, selective inhibitor of mTOR