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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling >> mTOR

mTOR

MTOR (mechanistic target of rapamycin) is a serine/threonine kinase that regulates cellular metabolism, growth ad survival. It mediates the cellular response to stress, growth factor and hormone etc. It is involved in cancer, aging and neurodegenerative diseases etc.

Products for  mTOR

  1. Cat.No. 产品名称 Information
  2. GC11607 Rapalink-1 第三代二价 mTOR 抑制剂 RapaLink-1 通过惰性化学接头将雷帕霉素与 MLN0128 结合。 RapaLink-1 显示出比雷帕霉素或 mTOR 激酶抑制剂 (TORKi) 更好的功效，可有效阻断癌症衍生的激活 mTOR 突变体。 RapaLink-1 可以穿过血脑屏障。 RapaLink-1 与 FKBP12 的结合导致 mTORC1 的靶向和持久抑制。 RapaLink-1 通过改善自噬在抗磷脂综合征中发挥抗血栓作用。抗癌活性。
  3. GC10228 GDC-0084 PI3K and mTOR inhibitor, brain-permeable
  4. GC15740 OXA-01 A selective dual inhibitor of mTORC1 and mTORC2
  5. GC13648 CC-223 A potent, selective inhibitor of mTOR
  6. GC16654 CC-115 A dual inhibitor of mTOR and DNA-PK
  7. GC14371 LY3023414 LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
  8. GC13790 MHY1485

    An mTOR activator
  9. GC17338 GNE-317 A dual PI3Kα and mTOR inhibitor
  10. GC10340 GNE-477 A dual PI3K and mTOR inhibitor
  11. GC15423 GNE-493 A dual inhibitor of PI3K and mTOR
  12. GC17330 (+)-Usniacin (+)-Usniacin 从地衣中分离出来，结合在 mTOR 的 ATP 结合口袋，并抑制 mTORC1/2 活性。 (+)-Usniacin 抑制 mTOR 下游效应子的磷酸化:Akt (Ser473)、4EBP1、S6K，诱导自噬，具有抗癌活性。 (+)-Usniacin 对许多浮游革兰氏阳性菌具有抗菌活性，包括金黄色葡萄球菌、粪肠球菌和粪肠球菌。
  13. GC10583 WAY-600 An mTOR inhibitor
  14. GC13071 Ridaforolimus (Deforolimus, MK-8669) A rapamycin analog that selectively inhibits mTOR in mTORC1
  15. GC13321 WYE-687 An mTOR inhibitor
  16. GC11177 GDC-0980 (RG7422) A dual inhibitor of PI3K and mTOR
  17. GC13858 Torin 2 Selective inhibitor of mTOR
  18. GC11018 GSK1059615 A potent PI3K inhibitor
  19. GC15653 PF-05212384 (PKI-587) A potent, dual PI3K/mTOR inhibitor
  20. GC14071 OSI-027 Dual mTORC1/mTORC2 inhibitor
  21. GC11003 PP121 A potent dual inhibitor of tyrosine and phosphoinositide kinases
  22. GC14675 WYE-125132 (WYE-132) Dual mTORC1/mTORC2 inhibitor
  23. GC10196 ETP-46464 An ATR inhibitor
  24. GC12773 Palomid 529 An inhibitor of mTORC1 and mTORC2 formation
  25. GC15072 GSK2126458 A potent pan-PI3K and mTOR inhibitor
  26. GC10969 INK 128 (MLN0128) Inhibitor of TORC1/2
  27. GC17104 PKI-402 A dual inhibitor of PI3K and mTOR
  28. GC16417 PF-04691502 PF-04691502 是一种有效的选择性 PI3K 和 mTOR 抑制剂。 PF-04691502 与人 PI3Kα、β、δ、γ 和 mTOR 结合，Kis 分别为 1.8、2.1、1.6、1.9 和 16 nM。
  29. GC16145 NVP-BGT226 A dual PI3K and mTOR inhibitor
  30. GC13029 AZD2014 A potent dual mTORC1/2 inhibitor
  31. GC15904 PP242 Potent inhibitor of mTOR kinase in both mTORC1 and mTORC2
  32. GC12573 Temsirolimus A specific inhibitor of mTOR activity
  33. GC10131 Torin 1

    Selective inhibitor of mTOR
  34. GC12021 GDC-0349 A potent inhibitor of mTOR
  35. GC14346 KU-0060648 A dual inhibitor of DNA-PK and PI3K
  36. GC16380 AZD8055 A potent mTOR inhibitor
  37. GC10662 WYE-354 Potent inhibitor of mTOR in both mTORC1 and mTORC2
  38. GC15167 KU-0063794 An inhibitor of mTORC1 and mTORC2
  39. GC11165 PI-103 A potent, cell-permeable PI3-kinase inhibitor
  40. GC10060 BEZ235 (NVP-BEZ235) A dual inhibitor of class I PI3Ks and mTOR
  41. GC16481 XL388 An mTOR inhibitor
  42. GC17771 VS-5584 (SB2343) A selective PI3K/mTOR kinase inhibitor
  43. GC18032 QL-IX-55 QL-IX-55 是一种选择性的 ATP 竞争性 mTORC1/2 抑制剂，对人 mTORC1/酵母 mTORC1/酵母 mTORC2 的 IC50 分别为 50/50/10-50 nM。
  44. GC16379 PI-103 Hydrochloride A potent, cell-permeable PI3K inhibitor
  45. GC18089 Nordihydroguaiaretic acid A non-selective LO inhibitor
  46. GC10900 GDC-mTOR inhibitor GDC-mTOR inhibitor 是一种具有显着选择性的 mTOR 抑制剂，Ki 为 1.5 nM。 GDC-mTOR inhibitor 在细胞和体内药代动力学 (PK)/药效学 (PD) 实验中抑制 mTORC1 和 mTORC2。
  47. GC12045 LY 303511 An inhibitor of cell proliferation
  48. GC13271 BEZ235 Tosylate BEZ235 Tosylate (BEZ235 Tosylate) 是一种双重 PI3K 和 mTOR 激酶抑制剂，对 PI3Kα, β, γ, δ 的 IC50 值分别为 4, 75, 7, 5 nM。 BEZ235 Tosylate (BEZ235 Tosylate) 抑制 mTORC1 和 mTORC2。
  49. GN10709 Polyphyllin A A steroid saponin with anticancer activity
  50. GN10583 Dihydromyricetin A flavanonol with diverse biological activities
  51. GN10127 Salidroside

    红景天苷是一种具有多种生物活性的糖苷，具有抗癌、抗氧化、抗衰老、抗糖尿病、抗糖尿病、抗高血压、抗炎、免疫调节等药理作用。

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