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PKB(蛋白激酶B)

PKB (protein kinase B) is a serine/threonine kinase (three isoforms, Akt-1/-2/-3) that mediates PI 3-K signaling. It plays an important role in metabolism, cell proliferation, cell survival, angiogenesis in tumor progresion etc.

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  2. GC16475 Afuresertib Afuresertib (GSK2110183) 是一种具有口服生物利用度、选择性、ATP 竞争性和有效的泛 Akt 激酶抑制剂,对 Akt1/Akt2/Akt3 的 Kis 分别为 0.08/2/2.6 nM。

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