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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling(PI3K/Akt/mTOR 信号传导)

  1. Cat.No. 产品名称 Information
  2. GC41573 Theaflavin 3,3'-digallate

    A polyphenol with diverse biological activities
  3. GC41527 Viridiol A phytotoxin
  4. GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone An intermediate in the synthesis of ubiquinones that has anticancer activity
  5. GC40650 CAY10706 A TrxR inhibitor
  6. GC40561 DNA-PK Inhibitor IV DNA-PK inhibitor IV is an inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 value of 400 nM for the DNA-PK-dependent phosphorylation of a p53 peptide substrate.
  7. GC19540 α-Linolenic Acid

    An essential ω-3 polyunsaturated fatty acid
  8. GC34909 JR-AB2-011 JR-AB2-011 is a potent inhibitor of mTOR-mLST8-mSIN1-Rictor complex (mTORC2) which can block mTORC2 signaling and Rictor association with mTOR at lower effective concentrations.
  9. GC34749 Rac-Nedisertib Rac-Nedisertib(Rac-M3814)是Nedisertib的外消旋体，为有效的DNA-PK抑制剂，IC50值小于3nM。
  10. GC34444 (R)-Nedisertib (R)-Nedisertib((R)-M3814)是一种活性较弱的Nedisertib的R型异构体，对DNA-PK的IC50值为7-30nM。
  11. GC34121 CC-115 hydrochloride A dual inhibitor of mTOR and DNA-PK
  12. GC34053 SOLENOPSIN Solenopsin是一种ATP-竞争型AKT抑制剂，withIC50值为10μM.
  13. GC33765 Palmitelaidic Acid (9-trans-Hexadecenoic acid) A dietary fatty acid
  14. GC19484 BAY1125976 An allosteric inhibitor of Akt1/2
  15. GC33385 PQR-530 A dual inhibitor of PI3Kα and mTOR
  16. GC33357 K-80003 (TX-803) K-80003 (TX-803) 是 tRXRα 的有效抑制剂；依赖 Akt 激活和癌细胞生长。
  17. GC33355 FT-1518 FT-1518是一种选择性的，可口服的，有效的新一代mTORC1和mTORC2抑制剂，具有抗肿瘤的活性。
  18. GC33325 VX-984 (M9831) VX-984 (M9831) (M9831) 是一种具有口服活性、强效、选择性和 BBB 穿透的 DNA-PK 抑制剂。 VX-984 (M9831) 有效抑制 NHEJ（非同源末端连接）并增加 DSB（DNA 双链断裂）。 VX-984 (M9831) 可用于胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSCLC) 研究。
  19. GC33308 AKT-IN-1 AKT-IN-1是一种变构AKT抑制剂，IC50为1.042μM。
  20. GC33162 Duvelisib R enantiomer (IPI-145 R enantiomer) Duvelisib R 对映异构体是一种 PI3K 抑制剂，是 Duvelisib 活性较低的对映异构体。
  21. GC33145 BEBT-908 (PI3Kα inhibitor 1) BEBT-908 (PI3Kα inhibitor 1) (PI3Kα inhibitor 1) 是一种选择性 PI3Kα从专利US/20120088764A1中提取的抑制剂化合物243，IC50<0.1 μM, PI3Kα抑制剂 1 还抑制 HDAC (0.1 μM≤IC50≤1 μM)。
  22. GC33135 GSK2110183 Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.
  23. GC33130 Recilisib (Ex-RAD) Recilisib (Ex-RAD) (ON 01210) 是一种辐射防护剂，可激活细胞中的 AKT、PI3K 活性。
  24. GC33115 Pomiferin (NSC 5113)

    Pomiferin (NSC 5113) (NSC 5113) 作为 HDAC 的潜在抑制剂，其 IC50 为 1.05 μM，并且还有效抑制 mTOR (IC50, 6.2 μM)。
  25. GC33014 NSC781406 A dual inhibitor of PI3K and mTOR
  26. GC33010 GSK2110183 hydrochloride GSK2110183 hydrochloride 是 GSK2110183 的结构类似物。
  27. GC32995 JNJ-47117096 hydrochloride (MELK-T1 hydrochloride) JNJ-47117096 hydrochloride (MELK-T1 hydrochloride) 是有效的选择性 MELK 抑制剂，IC50 为 23 nM，也有效抑制 Flt3，IC50 为 18 nM。
  28. GC32939 Akt1 and Akt2-IN-1 Akt1andAkt2-IN-1是一种有效的变构抑制剂,抑制Akt1(IC50=3.5nM)和Akt2(IC50=42nM)。
  29. GC32932 Vps34-IN-2 Vps34-IN-2是一种新型的，有效且有选择性的Vps34抑制剂，在Vps34酶促测定和GFP-FYVE细胞测定中的IC50值分别为2和82nM。
  30. GC32916 Parsaclisib (INCB050465) Parsaclisib (INCB050465, INCB-50465, IBI376) is a potent and highly selective PI3Kδ(PI3K delta) inhibitor with an IC50 of 1 nM at 1 mM ATP in biochemical assay and approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
  31. GC32892 PF-AKT400 (AKT protein kinase inhibitor) PF-AKT400（AKT 蛋白激酶抑制剂）是一种广泛选择性、强效、ATP 竞争性 Akt 抑制剂，对 PKBα 的选择性高出 900 倍； (IC50=0.5 nM) 比 PKA (IC50=450 nM)。
  32. GC32891 PQR620 PQR620 is a novel, selective, orally bioavailable and brain penetrant dual TORC1/2 inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.
  33. GC32847 PI4KIIIbeta-IN-9 PI4KIIIbeta-IN-9是一种有效的PI4KIIIβ抑制剂，IC50为7nM。PI4KIIIbeta-IN-9也抑制PI3Kδ和PI3Kγ，IC50分别为152nM和1046nM。
  34. GC32828 Tenalisib (RP6530) Tenalisib (RP6530) is a potent and selective dual PI3Kδ/γ inhibitor with IC50 values of 24.5 nM and 33.2 nM for PI3Kδ and PI3Kγ, respectively. Its selectivity over α and β isoforms are more than 300-fold and 100-fold, respectively.
  35. GC32794 Ipatasertib dihydrochloride (GDC-0068 (dihydrochloride)) A pan-Akt inhibitor
  36. GC32767 3BDO A butyrolactone derivative and autophagy inhibitor
  37. GC32736 MELK-8a hydrochloride A MELK inhibitor
  38. GC32718 M3814 (nedisertib) Nedisertib (M3814, Peposertib, MSC2490484A) is an orally bioavailable, highly potent and selective inhibitor of DNA activated protein kinase (DNA-PK) with IC50 of < 3 nM.
  39. GC32710 GDC-0077 (RG6114) Inavolisib (GDC-0077, RG6114, RO-7113755) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3.
  40. GC32510 Loureirin A Loureirin A is a flavonoid extracted from the red resin of the herbs of Dracaena cochinchinensis, which is known as Dragon's Blood. Loureirin A inhibits platelet activation by an impairment of PI3K/Akt signaling. Loureirin A inhibits Akt phosphorylation.
  41. GC32381 BF738735 BF738735是一种磷脂酰肌醇4-激酶IIIβ(PI4KIIIβ)抑制剂，IC50为5.7nM。
  42. GC32254 Deltonin Deltonin是从盾叶薯蓣中得到的甾体皂苷，能够抑制ERK1/2和AKT的活化，具有抗肿瘤的活性。
  43. GC32199 T-00127_HEV1 T-00127_HEV1是一个phosphatidylinositol4-kinaseIIIbeta(PI4KB)抑制剂，其IC50值为60nM。
  44. GC32163 BQR-695 (NVP-BQR695) An antimalarial compound
  45. GC32118 KDU691 An antimalarial compound
  46. GC31756 IPI-3063 IPI-3063 is a potent and selective p110δ inhibitor with biochemical IC50 of 2.5?±?1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.
  47. GC31751 PI3Kδ-IN-2

    PI3Kδ-IN-2 (YY-20394) 是 PI3K&#948 的强效、口服生物利用度和选择性抑制剂；提取自专利WO 2015055071 A1，化合物10； IC50 为 6.4 nM。
  48. GC31666 Seletalisib (UCB5857) Seletalisib (UCB-5857) is a novel small-molecule inhibitor of PI3Kδ with an IC50 value of 12 nM and shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (between 24- and 303-fold).
  49. GC31661 APY0201 An inhibitor of PIKFYVE
  50. GC31536 N-Oleoyl glycine

    A putative substrate for peptidyl glycine α-amidating enzyme
  51. GC31470 MK8722 MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.

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