DNA Damage/DNA Repair(DNA损伤/DNA修复)

Cat.No. 产品名称 Information

GC41695 (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)

Tetrahydrofolate, THFA

A folic acid derivative

GC41643 9(Z),11(E),13(E)-Octadecatrienoic Acid

αEleostearic Acid, αESA, LAF 237

A polyunsaturated fatty acid

GC41633 (R)-Prunasin

野黑樱苷

A cyanogenic glucoside

GC41598 Tyrocidine Complex An antibiotic complex

GC41384 K-TMZ A DNA alkylating agent

GC41340 Illudin M

隐陡头菌素M

A DNA alkylating agent

GC41112 Dihydroxy Melphalan

二羟基美法兰

An inactive degradation product of melphalan

GC41088 (6S)-Tetrahydrofolic Acid

An active diastereomer

GC41085 HDAC6 Inhibitor

Histone Deacetylase 6

An inhibitor of HDAC6

GC40859 Steffimycin B

司替霉素B

An anthracycline bacterial metabolite

GC40683 N-(2-hydroxyethyl)-Naphthalimide

N-(2-hydroxyethyl)-1,8-Naphthalimide, NSC 11547

A fluorescent probe

GC40641 5'-Ethynyl-2'-deoxycytidine

5-乙炔基-2'-脱氧胞苷

A nucleoside analog

GC40618 3',4',7-Trihydroxyisoflavone

3',4',7-三羟基异黄酮

A natural isoflavone

GC40477 4-Thiouracil

4-硫尿嘧啶

A photoreactive nucleobase analog

GC40468 1,5-Isoquinolinediol

1,5-二羟基异喹啉,NSC 65585

An inhibitor of poly(ADP-ribose) polymerases

GC40301 Tamoxifen N-oxide

他莫昔芬N-氧化物

A metabolite of tamoxifen

GC40298 N-acetyl-5-Aminosalicylic Acid

5-乙酰氨基水杨酸

A metabolite of 5-ASA and sulfasalazine

GC19542 GeA-69 GeA-69 是一种多聚腺苷二磷酸核糖聚合酶 14 (PARP14) 的选择性变构抑制剂，靶向大结构域 2 (MD2)，Kd 值为 2.1 µM。 GeA-69 参与 DNA 损伤修复机制并阻止 PARP14 MD2 募集到激光诱导的 DNA 损伤部位。

GC10456 Fucosterol

岩皂甾醇,24-ethylidene Cholesterol

A natural phytosterol with diverse biological activities

GC34749 Rac-Nedisertib Rac-Nedisertib(Rac-M3814)是Nedisertib的外消旋体，为有效的DNA-PK抑制剂，IC50值小于3nM。

GC34692 NU6140 A Cdk2 inhibitor

GC34670 MF-094 MF-094, a potent and selective USP30 inhibitor (IC50=0.12 μM), accelerates diabetic wound healing by inhibiting the NLRP3 inflammasome.

GC34650 Longdaysin

Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7.

GC34629 J22352 J22352是一种具有类似靶向嵌合体蛋白水解(PROTAC)特性、高度选择性HDAC6抑制剂，其IC50值为4.7nM，J22352通过抑制胶质母细胞瘤自噬、诱发抗肿瘤免疫反应来促进HDAC6降解和诱导抗癌效果，并通过降低PD-L1的免疫抑制活性，使宿主抗肿瘤活性恢复。

GC34536 CK1-IN-1 CK1-IN-1 (PUN51207, Compound 1C) is an inhibitor of casein kinase 1 (CK1) with IC50 of 15 nM, 16 nM and 73 nM for CK1δ, CK1ε and p38α MAPK, respectively.

GC34498 Bobcat339 hydrochloride A cytosine derivative

GC34458 ACY-1083

ACY-1083是一种可渗透脑的选择性HDAC6抑制剂，IC50为3nM，ACY-1083对HDAC6的选择性比其他类别的HDAC亚型高260倍。ACY-1083可有效逆转化疗引起的周围神经病变。

GC34452 3,7,4'-Trihydroxyflavone

5-脱氧莰非醇,5-Deoxykampferol

3,7,4'-Trihydroxyflavone是从Rhusjavanicavar.roxburghiana中分离得到的一种具有DNA断链活性的黄酮类化合物。

GC34444 (R)-Nedisertib (R)-Nedisertib((R)-M3814)是一种活性较弱的Nedisertib的R型异构体，对DNA-PK的IC50值为7-30nM。

GC19506 NITD008

7-脱氮-2'-C-乙炔腺苷,7-Deaza-2'-C-acetylene-adenosine

NITD008 是一种有效的选择性黄病毒抑制剂，可抑制 2 型登革热病毒 (DENV-2)，EC50 为 0.64 μM。

GC19505 RK-287107 A TNKS1/2 inhibitor

GC19495 DL-Folinic Acid (calcium salt)

亚叶酸钙; Leucovorin calcium; Calcium folinate

A reduced folic acid

GC40195 Etoposide-d3

EPE-d3, VP-16-123-d3

An internal standard for the quantification of etoposide

GC40103 Herboxidiene

GEX1A

Herboxidiene 作为一种有效的抗肿瘤剂，可以靶向剪接体的 SF3B 亚基。

GC40092 PD 0332991-d8

帕博西尼-D8,PD 0332991-d8

An internal standard for the quantification of PD 0332991

GC40076 (-)-Voacangarine

NSC 306219, (-)-Voacristine

A cytotoxic indole alkaloid

GC40032 Antipain (hydrochloride)

抗痛素二盐酸盐

A protease inhibitor

GC40005 Aurodox

1-methyl-Mocimycin

A polyketide antibiotic

GC34422 Atuveciclib (BAY-1143572) Atuveciclib(BAY-1143572)是一种口服有效的高选择性PTEFb/CDK9抑制剂。Atuveciclib(BAY-1143572)抑制CDK9/CycT1，IC50为13nM。

GC34421 Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) AtuveciclibS-Enantiomer(BAY-1143572S-Enantiomer)是一种有效的选择性CDK9抑制剂，抑制CDK9/CycT1，IC50为16nM。

GC34384 3,6-DMAD hydrochloride 3,6-DMADhydrochloride是未折叠蛋白质应答(IRE1α-XBP1)通路的抑制剂。

GC34374 BAY-1895344 hydrochloride An ATR inhibitor

GC34356 Casein Kinase II Inhibitor IV Hydrochloride CaseinKinaseIIInhibitorIVHydrochloride是表皮角质形成细胞分化的小分子诱导剂。

GC34355 SEL120-34A monohydrochloride A dual inhibitor of Cdk8 and Cdk19

GC34354 GSK2643943A GSK2643943A is an inhibitor of deubiquitylating enzyme (DUB) with IC50 of 160 nM for USP20/Ub-Rho.

GC34309 Cycloguanil D6 (Chlorguanide triazine D6) CycloguanilD6是Cycloguanil的氘代化合物标准品。

GC34305 Bendamustine D4 (SDX-105 D4) BendamustineD4是Bendamustine的氘代化合物标准品。Bendamustine是一种DNA交联剂(DNAcrosslinker)，能够导致DNA断裂，具有烷基化和抗代谢物的作用。

GC34205 GSK2850163 hydrochloride GSK2850163hydrochloride是一个新型的肌醇需要酶-1α(IRE1α)抑制剂，它可抑制IRE1α的激酶活性和RNA酶活性，其IC50值分别为20和200nM。

GC34204 JSH-150 JSH-150 is a highly selective and potent inhibitor of CDK9 with IC50 of 1 nM.

GC34195 K-756 K-756是一种直接的选择性tankyrase(TNKS)抑制剂，抑制TNKS1和TNKS2的ADP-核糖基化活性，IC50分别为31和36nM。