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DL-Folinic Acid (calcium salt) Sale

(Synonyms: 亚叶酸钙; Leucovorin calcium; Calcium folinate) 目录号 : GC19495

A reduced folic acid

DL-Folinic Acid (calcium salt) Chemical Structure

Cas No.:1492-18-8

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产品描述

Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].

MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) [1].

Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].

References:
[1]. Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397(2):221-8.
[2]. Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.

Chemical Properties

Cas No. 1492-18-8 SDF
别名 亚叶酸钙; Leucovorin calcium; Calcium folinate
化学名 N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, monocalcium salt
Canonical SMILES O=CN1C(CNC2=CC=C(C(N[C@H](C([O-])=O)CCC([O-])=O)=O)C=C2)CNC3=C1C(N=C(N)N3)=O.[Ca+2]
分子式 C20H21N7O7 • Ca 分子量 511.5
溶解度 Water: 0.3 mg/ml 储存条件 4°C, protect from light ,unstable in solution, ready to use.
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.955 mL 9.7752 mL 19.5503 mL
5 mM 0.391 mL 1.955 mL 3.9101 mL
10 mM 0.1955 mL 0.9775 mL 1.955 mL
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