MAPK Signaling(MAPK信号通路)

Cat.No. 产品名称 Information

GC47166 Dabrafenib-d9 An internal standard for the quantification of dabrafenib

GC47088 Cilostazol-d4 An internal standard for the quantification of cilostazol

GC47045 Carvedilol-d5 An internal standard for the quantification of carvedilol

GC46957 Bumetanide-d5 An internal standard for the quantification of bumetanide

GC46808 ADTL-EI1712 A dual ERK1 and ERK5 inhibitor

GC46554 2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate An immunogenic derivative of cAMP

GC60886 GSK356278 A selective PDE4 inhbitor

GC60812 ERK1/2 inhibitor 2 An ERK inhibitor

GC60393 (-)-Zuonin A (-)-ZuoninA(D-Epigalbacin)是一种天然木质素，是有效的、选择性的JNKs抑制剂，对JNK1、JNK2和JNK3作用的IC50值分别为1.7μM,2.9μM和1.74μM。

GC60262 N-Feruloyloctopamine N-Feruloyloctopamine，从 Garlic 皮中分离出来的，是一种抗氧化剂成分。N-Feruloyloctopamine 显着降低 Akt 和 p38 MAPK 磷酸化水平。

GC60037 A-3 hydrochloride A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.

GC39815 Semapimod tetrahydrochloride Semapimod tetrahydrochloride (CNI-1493) 是促炎细胞因子产生 (proinflammatory cytokine) 的抑制剂，可抑制TNF-α、IL-1β 和 IL-6。Semapimod tetrahydrochloride 抑制巨噬细胞 p38 MAPK 和一氧化氮生成。Semapimod tetrahydrochloride 抑制 TLR4 信号 (IC50≈0.3 μM)。Semapimod tetrahydrochloride 在多种炎症和自身免疫性疾病中具有潜在的作用。

GC39485 CK2/ERK8-IN-1 A dual inhibitor of CK2 and ERK8

GC39325 2,5-Dihydroxyacetophenone 2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. 2',5'-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression. 2',5'-Dihydroxyacetophenone significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.

GC50502 RI-STAD 2 AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable

GC50501 STAD 2 STAD 2 是 PKA-RII 的有效选择性破坏剂，Kd 为 6.2 nM。

GC50407 st-Ht31 P Negative control for st-Ht31

GC50406 st-Ht31 Inhibits PKA/AKAP interactions; cell permeable

GC50400 CC 401 dihydrochloride A potent, specific pan-JNK inhibitor

GC50316 Org 48762-0 Selective p38α/β inhibitor; orally bioavailable

GC50295 TL4-12 TL4 12 是一种有效的选择性 GCK（生发中心激酶）抑制剂。

GC50294 RMM 46 An inhibitor of RSK2

GC50252 PF 06260933 dihydrochloride MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK

GC50181 CW 008 PKA signaling activator; promotes osteogenesis from hMSCs

GC46123 Comprehensive Kinase Screening Library For screening of a variety of kinase inhibitors

GC39095 Isoliquiritin apioside Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.

GC39074 Tenuifoliside A Tenuifoliside A 分离自远志，具有抗凋亡和抗抑郁作用。在 C6 细胞中，Tenuifoliside A 表现出其神经营养作用，并通过 ERK/CREB/BDNF 信号通路促进细胞增殖。

GC38917 Gossypetin A flavonoid with diverse biological activities

GC46015 KY 05009 A TNIK inhibitor

GC38804 JWG-071 JWG-071 是首次报道的 ERK5 激酶选择性化学探针。JWG-071 提高了 ERK5 活性和 BRD4 选择性。JWG-071 将是反卷积 ERK5 和 BRD4 药理学急需的化学探针。

GC38791 GSK-25 GSK-25 是一种有效的、选择性的，具有口服活性的 ROCK1 抑制剂 (IC50=7 nM)。GSK-25 对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性 (RSK1: IC50=398 nM, p70S6K: IC50=1 μM)。GSK-25 可抑制 P450 (CYP2C9、CYP2D6、CYP3A4的IC50 分别为2.5、5.2、2.5 μM)。

GC38755 CKI-7 A CK1 inhibitor

GC38738 Azosemide Azosemide is a potent Na+–K+–2Cl? cotransporter NKCC1 inhibitor with IC50s of 0.246??M for hNKCC1A and 0.197??M for NKCC1B, respectively.

GC38708 Esculin A coumarin with antioxidant and anti-inflammatory activities

GC38679 Urolithin B A metabolite of ellagic acid

GC38653 Selumetinib sulfate Selumetinib (AZD6244) 是一种高效选择性的，非 ATP 竞争性的 MEK1/2 抑制剂，抑制 MEK1 的 IC50 为 14 nM。Selumetinib (AZD6244) 抑制 MEK1/2 磷酸化水平。

GC38609 Rotundic acid Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.

GC38518 AMG-548 dihydrochloride An inhibitor of p38α MAPK

GC38319 Dihydrocaffeic acid A polyphenol with diverse biological activities

GC38202 DTP3 TFA DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.

GC38053 WHI-P258 A negative control for JAK3 inhibition

GA20623 Ac-muramyl-Ala-D-Glu-NH₂ Ac-muramyl-Ala-D-Glu-NH₂ (MDP) 是一种合成的免疫反应肽，由连接到 L-Ala-D-isoGln 短氨基酸链上的 N-乙酰胞壁酸组成。

GC37665 Sorafenib (D4) Sorafenib D4 (Bay 43-9006 D4) 是 Sorafenib 氘代化合物标准品。Sorafenib 是一种多激酶抑制剂，抑制 Raf-1，B-Raf 和 VEGFR-3 的 IC50 分别为6 nM，20 nM，22 nM。

GC37664 Sorafenib (D3) An internal standard for the quantification of sorafenib

GC37646 SKF-86002 An anti-inflammatory agent

GC37595 SB 242235 A p38α MAPK inhibitor

GC37523 RGB-286638 free base A multi-kinase inhibitor

GC37522 RGB-286638 A multi-kinase inhibitor

GC37516 Refametinib R enantiomer Refametinib R enantiomer 是一种 MEK 抑制剂，EC50为 2.0-15 nM，详细信息请参考专利文献WO2007014011A2 中的化合物 1022。

GC37071 Ravoxertinib hydrochloride Ravoxertinib hydrochloride (GDC-0994 hydrochloride) 是一种可口服的 ERK 抑制剂，对 ERK1 和 ERK2 的 IC50 值分别为 6.1 nM 和 3.1 nM。

MAPK Signaling(MAPK信号通路)

Products for MAPK Signaling