TGF-β / Smad Signaling(TGF-β / Smad 信号转导)
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).
TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.
Products for TGF-β / Smad Signaling
- Cat.No. 产品名称 Information
- GC14407 PF-431396 A FAK/PYK2 dual inhibitor
- GC13914 Flumatinib mesylate A Bcr-Abl inhibitor
- GC12779 PPY A PPY A 是一种有效的 T315I 突变体和野生型 Abl 激酶抑制剂,IC50 分别为 9 和 20 nM。 PPY A 抑制用野生型 Abl 和 Abl T315I 突变体转化的 Ba⁄F3 细胞,IC50 分别为 390 和 180 nM。 PPY A可用于慢性粒细胞白血病(CML)的研究。
- GC12637 PD 180970 An inhibitor of Bcr-Abl
- GC12172 1-Naphthyl PP1 Inhibitor of modified ‘analog-sensitive’ kinases
- GC15079 GNF 5 An allosteric inhibitor of Bcr-Abl
- GC10858 GNF 2 An allosteric inhibitor of Bcr-Abl
- GC15579 Adaphostin Adaphostin (NSC 680410) 是 AG957 的金刚烷基酯,是一种有效的 p210bcr/abl 抑制剂 (IC50=14 μM)。 Adaphostin 在人 T 淋巴细胞白血病细胞系中诱导细胞凋亡(IC50 范围为 17 至 216 nM)。 Adaphostin 对慢性和急性髓性白血病细胞具有显着的选择性活性。 Adaphostin 增加了 CLL B 细胞内的活性氧 (ROS) 水平。
- GC16821 TAE226(NVP-TAE226) A dual inhibitor of FAK and IGF-1R
- GC15520 Sotrastaurin (AEB071) A PKC and GSK3 inhibitor
-
GC14075
Nocodazole
A microtubule altering agent
- GC12363 LY2109761 A dual inhibitor of TGF-β type 1/type II receptor kinases
- GC15281 K-252c A cell-permeable PKC inhibitor
- GC16907 Go 6983 Inhibitor of protein kinase C
- GC15431 GF 109203X (Bisindolylmaleimide I) A PKC inhibitor
- GC15564 Go 6976 A PKCα/β1 inhibitor
- GC10810 PF-562271 HCl PF-562271 (VS-6062) hydrochloride 是一种有效的 ATP 竞争性和可逆的 FAK 和 Pyk2 激酶抑制剂,IC50 分别为 1.5 nM 和 13 nM。
- GC18015 LY2157299 A TGF-β type 1 receptor kinase inhibitor
-
GC16580
LDN-193189
An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6
- GC10970 WP1130 A deubiquitinase inhibitor
- GC14767 PF-00562271 A selective FAK/PYK2 inhibitor
- GC15380 PF-562271 A selective FAK/PYK2 inhibitor
- GC11878 GW788388 An inhibitor of ALK5 (TGFBR1)
- GC14289 Fasudil (HA-1077) HCl Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μ ;M, 1.650 μM 分别代表 ROCK2 和 PKA、PKC、PKG。 Fasudil (HA-1077) HCl 也是一种有效的 Ca2+ 通道拮抗剂和血管扩张剂。
- GC18119 GSK429286A A ROCK inhibitor
- GC14349 SB525334 A potent inhibitor of TGF-β R1/ALK5 kinase
- GC14396 Ponatinib (AP24534) An inhibitor of native and mutant Bcr-Abl
- GC11181 Thiazovivin A ROCK inhibitor
- GC15197 Saracatinib (AZD0530) A dual inhibitor of c-Src and Abl
- GC14701 Zoledronic Acid A bisphosphonate that inhibits bone resorption
- GC11759 Imatinib Mesylate (STI571) An inhibitor of c-Abl, Bcr-Abl, PDGFR, and c-Kit
- GC11499 Enzastaurin (LY317615) An inhibitor of PKC and Akt signaling
- GC13343 Bosutinib (SKI-606) An inhibitor of Src and Abl kinases
-
GC11545
SB 431542
SB-431542是一种小分子抑制剂。
- GC14129 Nilotinib(AMN-107) A Bcr-Abl inhibitor
- GC16584 TCS 21311 A JAK3 inhibitor
- GC13102 XL228 A tyrosine kinase inhibitor
- GC12827 SLx-2119 A ROCK2 inhibitor
- GC13904 SD-208 A potent, selective inhibitor of TGF-βRI
- GC10421 SB-505124 hydrochloride Inhibitor of receptors ALK4, ALK5, and ALK7
- GC15437 RKI-1447 A ROCK1 and ROCK2 inhibitor
- GC16793 RepSox A selective inhibitor of ALK5
- GC14237 Nilotinib monohydrochloride monohydrate A Bcr-Abl inhibitor
- GC13514 NG25 An inhibitor of MAP4K2 and TAK1
- GC12491 Narciclasine A plant growth regulator with anticancer activity
- GC14931 LDN193189 Hydrochloride An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6
- GC10338 Hydroxyfasudil hydrochloride A ROCK inhibitor
- GC10901 Hydroxyfasudil Hydroxyfasudil 是一种 ROCK 抑制剂,对 ROCK1 和 ROCK2 的 IC50 分别为 0.73 和 0.72 μM。
- GC16097 Chroman 1 A ROCK2 inhibitor
- GC13065 Chelerythrine Chloride Potent inhibitor of PKC and Bcl-xL