Home >> Signaling Pathways >> TGF-β / Smad Signaling

TGF-β / Smad Signaling(TGF-β / Smad 信号转导)

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Products for  TGF-β / Smad Signaling

  1. Cat.No. 产品名称 Information
  2. GC14407 PF-431396 A FAK/PYK2 dual inhibitor
  3. GC13914 Flumatinib mesylate A Bcr-Abl inhibitor
  4. GC12779 PPY A PPY A 是一种有效的 T315I 突变体和野生型 Abl 激酶抑制剂,IC50 分别为 9 和 20 nM。 PPY A 抑制用野生型 Abl 和 Abl T315I 突变体转化的 Ba⁄F3 细胞,IC50 分别为 390 和 180 nM。 PPY A可用于慢性粒细胞白血病(CML)的研究。
  5. GC12637 PD 180970 An inhibitor of Bcr-Abl
  6. GC12172 1-Naphthyl PP1 Inhibitor of modified ‘analog-sensitive’ kinases
  7. GC15079 GNF 5 An allosteric inhibitor of Bcr-Abl
  8. GC10858 GNF 2 An allosteric inhibitor of Bcr-Abl
  9. GC15579 Adaphostin Adaphostin (NSC 680410) 是 AG957 的金刚烷基酯,是一种有效的 p210bcr/abl 抑制剂 (IC50=14 μM)。 Adaphostin 在人 T 淋巴细胞白血病细胞系中诱导细胞凋亡(IC50 范围为 17 至 216 nM)。 Adaphostin 对慢性和急性髓性白血病细胞具有显着的选择性活性。 Adaphostin 增加了 CLL B 细胞内的活性氧 (ROS) 水平。
  10. GC16821 TAE226(NVP-TAE226) A dual inhibitor of FAK and IGF-1R
  11. GC15520 Sotrastaurin (AEB071) A PKC and GSK3 inhibitor
  12. GC14075 Nocodazole

    A microtubule altering agent

  13. GC12363 LY2109761 A dual inhibitor of TGF-β type 1/type II receptor kinases
  14. GC15281 K-252c A cell-permeable PKC inhibitor
  15. GC16907 Go 6983 Inhibitor of protein kinase C
  16. GC15431 GF 109203X (Bisindolylmaleimide I) A PKC inhibitor
  17. GC15564 Go 6976 A PKCα/β1 inhibitor
  18. GC10810 PF-562271 HCl PF-562271 (VS-6062) hydrochloride 是一种有效的 ATP 竞争性和可逆的 FAK 和 Pyk2 激酶抑制剂,IC50 分别为 1.5 nM 和 13 nM。
  19. GC18015 LY2157299 A TGF-β type 1 receptor kinase inhibitor
  20. GC16580 LDN-193189

    An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6

  21. GC10970 WP1130 A deubiquitinase inhibitor
  22. GC14767 PF-00562271 A selective FAK/PYK2 inhibitor
  23. GC15380 PF-562271 A selective FAK/PYK2 inhibitor
  24. GC11878 GW788388 An inhibitor of ALK5 (TGFBR1)
  25. GC14289 Fasudil (HA-1077) HCl Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μ ;M, 1.650 μM 分别代表 ROCK2 和 PKA、PKC、PKG。 Fasudil (HA-1077) HCl 也是一种有效的 Ca2+ 通道拮抗剂和血管扩张剂。
  26. GC18119 GSK429286A A ROCK inhibitor
  27. GC14349 SB525334 A potent inhibitor of TGF-β R1/ALK5 kinase
  28. GC14396 Ponatinib (AP24534) An inhibitor of native and mutant Bcr-Abl
  29. GC11181 Thiazovivin A ROCK inhibitor
  30. GC15197 Saracatinib (AZD0530) A dual inhibitor of c-Src and Abl
  31. GC14701 Zoledronic Acid A bisphosphonate that inhibits bone resorption
  32. GC11759 Imatinib Mesylate (STI571) An inhibitor of c-Abl, Bcr-Abl, PDGFR, and c-Kit
  33. GC11499 Enzastaurin (LY317615) An inhibitor of PKC and Akt signaling
  34. GC13343 Bosutinib (SKI-606) An inhibitor of Src and Abl kinases
  35. GC11545 SB 431542

    SB-431542是一种小分子抑制剂。

  36. GC14129 Nilotinib(AMN-107) A Bcr-Abl inhibitor
  37. GC16584 TCS 21311 A JAK3 inhibitor
  38. GC13102 XL228 A tyrosine kinase inhibitor
  39. GC12827 SLx-2119 A ROCK2 inhibitor
  40. GC13904 SD-208 A potent, selective inhibitor of TGF-βRI
  41. GC10421 SB-505124 hydrochloride Inhibitor of receptors ALK4, ALK5, and ALK7
  42. GC15437 RKI-1447 A ROCK1 and ROCK2 inhibitor
  43. GC16793 RepSox A selective inhibitor of ALK5
  44. GC14237 Nilotinib monohydrochloride monohydrate A Bcr-Abl inhibitor
  45. GC13514 NG25 An inhibitor of MAP4K2 and TAK1
  46. GC12491 Narciclasine A plant growth regulator with anticancer activity
  47. GC14931 LDN193189 Hydrochloride An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6
  48. GC10338 Hydroxyfasudil hydrochloride A ROCK inhibitor
  49. GC10901 Hydroxyfasudil Hydroxyfasudil 是一种 ROCK 抑制剂,对 ROCK1 和 ROCK2 的 IC50 分别为 0.73 和 0.72 μM。
  50. GC16097 Chroman 1 A ROCK2 inhibitor
  51. GC13065 Chelerythrine Chloride Potent inhibitor of PKC and Bcl-xL

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