TGF-β / Smad Signaling(TGF-β / Smad 信号转导)
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).
TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.
Products for TGF-β / Smad Signaling
- Cat.No. 产品名称 Information
- GC13320 SC-10 Protein kinase C activator
- GC16510 ZIP, Biotinylated ZIP with a biotin moiety covalently attached
- GC15345 [Ala113]-MBP (104-118) [Ala113]-MBP (104-118) 是一种蛋白激酶 C (PKC) 的非竞争性肽抑制剂,IC50 范围为 28-62 μM。
- GC17727 [Ala107]-MBP (104-118) [Ala107]-MBP (104-118) 是一种蛋白激酶 C (PKC) 的非竞争性肽抑制剂,IC50 范围为 46-145 μM。
- GC11671 PKC fragment (530-558) Potent activator of protein kinase C
- GC15471 PKC β pseudosubstrate Selective cell-permeable peptide inhibitor of protein kinase C
- GC10404 PKC ζ pseudosubstrate PKC ζ pseudosubstrate 是一种选择性的细胞渗透性 PKC 抑制剂。
- GC11803 Pseudo RACK1 Activator of protein kinase C
- GC15148 Ionomycin calcium salt Ionomycin calcium salt是一种窄谱抗生素,对革兰氏阳性菌具有活性,由丛生链霉菌(Streptomyces conglobatus)产生。伊诺霉素钙盐可促进细胞凋亡。伊诺霉素还能诱导激活蛋白激酶 C (PKC)。.
- GC17563 LY 333531 hydrochloride A PKCβ inhibitor
- GC17352 Phorbol 12,13-dibutyrate An activator of PKC
- GC12027 FR 236924 An activator of PKCε
- GC10687 CGP 53353 CGP 53353 (DAPH-7) 是一种有效的 PKC 抑制剂,对 PKCβII 和 PKCβI 的 IC50 分别为 0.41 mM 和 3.8 mM。
- GC17670 Bryostatin 1 A marine macrolide with diverse biological activities
- GC15446 Ionomycin free acid A calcium ionophore
- GC11362 K 252a A non-selective PKC inhibitor
- GC11159 Calphostin C A selective PKC inhibitor
- GC13677 Ro 32-0432 hydrochloride Ro 32-0432 hydrochloride 是一种有效的、选择性的、ATP 竞争性和口服活性的 PKC 抑制剂。
- GC17346 KT 5823 Potent selective inhibitor of cGMP-dependent protein kinase (PKG)
- GC17767 Dihydrosphingosine A mixture of sphingolipid pathway intermediates
- GC17591 D-erythro-Sphingosine (synthetic) A pharmacological tool to probe the activity of protein kinase C
- GC13890 (±)-Palmitoylcarnitine chloride A long-chain acylcarnitine with intracellular and extracellular roles
- GC17712 AT13148 A multi-AGC kinase inhibitor
- GC10496 Midostaurin (PKC412) Kinase inhibitor with potential use in cancer treatment
- GC17582 ML347 A selective ALK1 and ALK2 inhibitor
- GC17035 LDN-212854 An ALK2 inhibitor
- GC14298 DMH-1 A potent ALK2 inhibitor
- GC13869 Fasudil Fasudil (HA-1077; AT877) 是一种非特异性 RhoA/ROCK 抑制剂,对蛋白激酶也有抑制作用,对 ROCK1 的 Ki 为 0.33 μM,对 ROCK2 和 PKA 的 IC50 分别为 0.158 μM 和 4.58 μM、12.30 μM、1.650 μM ,PKC,PKG,分别。 Fasudil 也是一种有效的 Ca2+ 通道拮抗剂和血管扩张剂。
- GC16934 Valrubicin A semisynthetic anthracycline antitumor antibiotic
- GC13461 ZIP (SCRAMBLED) ZIP (SCRAMBLED) 是 zeta 抑制肽 (ZIP) 的乱序对照肽。
- GC17936 GSK269962A A ROCK1 and ROCK2 inhibitor
- GC12790 Pirfenidone A pyridone derivative with antifibrotic activity
- GC14363 Mitoxantrone HCl An inhibitor of DNA topoisomerase IIα and HIV-1 integrase
- GC11604 LY364947 Inhibitor of TGF-β type-1 receptors
- GC16354 Dequalinium Chloride An ammonium cation with diverse biological activities
- GC17523 Hydrochlorothiazide A thiazide diuretic
- GC10314 Imatinib (STI571) 伊马替尼 (STI571) (STI571) 是一种口服生物可利用的酪氨酸激酶抑制剂,可选择性抑制 BCR/ABL、v-Abl、PDGFR 和 c-kit 激酶活性。伊马替尼 (STI571) (STI571) 通过在 ATP 结合位点附近结合而起作用,将其锁定在封闭或自我抑制的构象中,从而半竞争性地抑制蛋白质的酶活性。伊马替尼 (STI571) 也是 SARS-CoV 和 MERS-CoV 的抑制剂。
- GC17322 Ro 31-8220 Ro 31-8220 是一种有效的 PKC 抑制剂,对 PKCα、PKCβI、PKCβII、PKCγ、PKCε 和大鼠脑 PKC 的 IC50 分别为 5、24、14、27、24 和 23 nM。
- GC13769 SB505124 Inhibitor of receptors ALK4, ALK5, and ALK7
- GC10722 SR-3677 A ROCK1 and ROCK2 inhibitor
- GC14007 DCC-2036 (Rebastinib) An orally bioavailable tyrosine kinase inhibitor
- GC15712 Y-27632 A ROCK inhibitor
- GC13423 Y-39983 dihydrochloride ROCK family inhibitor
- GC13232 Verbascoside A natural phenylpropanoid glucoside with diverse biological activities
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GC17243
Dorsomorphin (Compound C)
A potent, selective AMPK inhibitor
- GC15567 K02288 A BMP signaling inhibitor
- GC10915 GZD824 A Bcr/Abl inhibitor
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GC12560
Dorsomorphin (Compound C) 2HCl
A potent, reversible AMPK inhibitor
- GC13592 PD173955 A tyrosine kinase inhibitor
- GC15420 ICP 103 Protein kinase inhibitor