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Home >> Signaling Pathways >> Endocrinology and Hormones

Endocrinology and Hormones(内分泌和激素)

Endocrinology and Hormones

The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more

Products for  Endocrinology and Hormones

  1. Cat.No. 产品名称 Information
  2. GC41300 17β-hydroxy Exemestane An active metabolite of exemestane
  3. GC41266 Pregnanediol-3-Glucuronide A metabolite of progesterone
  4. GC41187 Boldenone Cypionate An Analytical Reference Standard
  5. GC41153 Tibolone A tissue-selective steroid with estrogenic and androgenic effects
  6. GC40968 21-hydroxy Eplerenone A major metabolite of eplerenone
  7. GC40960 20α-dihydro Prednisolone A metabolite of prednisolone
  8. GC40911 Glycine-β-muricholic Acid

    An intestine-selective FXR antagonist
  9. GC40867 Diflorasone Diacetate A corticosteroid
  10. GC40833 (E/Z)-Endoxifen An active metabolite of tamoxifen
  11. GC40571 24(S),25-epoxy Cholesterol An oxysterol
  12. GC40465 9(S)-HETE A monohydroxy fatty acid and RXRγ agonist
  13. GC40464 9(R)-HETE Enantiomer of (±)9-HETE; RXRγ activator
  14. GC40454 16(S)-HETE A potent inhibitor of proximal tubule ATPase activity
  15. GC40341 Tetrahydro-11-deoxy Cortisol A metabolite of 11-deoxycortisol
  16. GC40301 Tamoxifen N-oxide A metabolite of tamoxifen
  17. GC40293 Z3-Dodecenyl E2-butenoate A synthetic female sex pheromone
  18. GC34887 Androstanolone acetate Androstanoloneacetate是一种雄激素配体，靶向作用于雄激素受体α(AR)。Androstanoloneacetate通过连接桥与cIAP1配体Bestatin结合从而形成PROTAC分子。
  19. GC34862 WYC-209 WYC-209是一种合成类视黄醇，能抑制恶性小鼠黑色素瘤肿瘤再生细胞(TRC)的增殖，IC50值为0.19μM。WYC-209主要细胞靶点是维甲酸受体(RARs)。
  20. GC34824 T4-ATA S-isomer T4-ATAS-isomer是T4-ATA的S-异构体，是甲状腺激素的活性形式。
  21. GC34822 T3-ATA S-isomer T3-ATAS-isomer是T3-ATA的S-异构体，是甲状腺激素的活性形式。
  22. GC34740 PROTAC RAR Degrader-1 PROTACRARDegrader-1包含cIAP1配体结合基团，linker和RAR配体结合基团。在HT1080细胞中，PROTACRARDegrader-1降低RAR水平，30μM浓度时达到最大降解程度。同时，基于cIAP1的降解剂也被称为SNIPER。
  23. GC34686 Nidufexor

    An FXR partial agonist
  24. GP21262 Goserelin Goserelin (ICI 118630) 是促性腺激素释放激素 (GnRH/LHRH) 的十肽类似物，可作为 GnRH 激动剂发挥作用。
  25. GC19500 LY2795050 A κ-opioid receptor antagonist
  26. GC40109 Ketoconazole-d3 An internal standard for the quantification of ketoconazole
  27. GC40053 5α,6α-epoxy Cholestanol An oxysterol
  28. GC40049 Glucocorticoid Resistance Inhibitor An inhibitor of glucocorticoid resistance
  29. GC40024 Altenusin A fungal metabolite with diverse biological activities
  30. GC34223 Dermorphin Analog DermorphinAnalog是Dermorphin的类似物。Dermorphin为两栖类皮肤中发现的天然七肽，为μ-阿片受体(μ-opioidreceptor)激动剂。
  31. GC34173 LG-100064 LG-100064是一种类视黄醇X受体(retinoid-X-receptor(RXR))激动剂，对RXRα，RXRβ和RXRγ的EC50值分别为330nM，200nM和260nM；LG-100064可用于癌症研究。
  32. GC34099 Buserelin Acetate Buserelin(INN)Acetate是一个GnRH的激动剂。
  33. GC34005 Dehydroisoandrosterone 3-acetate (Dehydroepiandrosterone 3-acetate) Dehydroepiandrosterone 3-acetate 是一种睾酮/雌激素前体和已知的脊椎动物攻击性调节剂。
  34. GC34001 Gonadorelin acetate A tropic hormone
  35. GC33845 Protirelin Acetate (TRF Acetate) Protirelin (Thyroliberin, Lopremone, Synthetic TRH, Thyrotropin-releasing hormone, Rifathyroin) is a tripeptide that stimulates the release of thyrotropin and prolactin.
  36. GC33784 β-Casomorphin, human (Human β-casomorphin 7) 是一种阿片肽，作为阿片受体的激动剂。
  37. GC33764 Eprotirome (KB2115) A thyroid hormone mimetic
  38. GC33736 β-Casomorphin, bovine (β-Casomorphin-7 (bovine)) β-Casomorphin, bovine (β-Casomorphin-7 (bovine)) (β-Casomorphin-7 (bovine) ) 是一种阿片肽，在阿片受体结合试验中的 IC50 为 14 μM。
  39. GC33673 24-Hydroxycholesterol

    24-Hydroxycholesterol是一种天然的固醇类物质，是n-甲基-d-天门冬氨酸受体(NMDA)和转录因子LXR的激活剂。
  40. GC33467 Cetrorelix Acetate (SB-075 acetate) A synthetic peptide GnRHR antagonist
  41. GC33315 AGN 194078 AGN194078是一个有选择性的RARα激动剂，其Kd和EC50值分别为3和112nM。
  42. GC33224 Proxalutamide (GT0918) Proxalutamide (GT0918) is a second-generation androgen receptor antagonist that binds to the ligand-binding domain of AR with an IC50 of 32 nM in the AR competive binding assays.
  43. GC33081 [D-Ala2]leucine-enkephalin [D-Ala2]leucine-enkephalin是一种δ阿片类(deltaopioid)激动剂，是一种能长效抗降解的亮氨酸脑非肽。
  44. GC33034 Lecirelin Lecirelin是GnRH的合成类似物，可用于治疗牛卵巢滤泡囊肿。
  45. GC32953 Epristeride (ONO-9302) Episteride (ONO-9302) (ONO-9302) 是一种选择性、特异性和口服活性的非竞争性人类固醇 5 α-还原酶异构体 2 抑制剂。Epristeride (ONO-9302) 对 SR 同工酶 2 型具有抑制作用，Ki 值为 0.7 -2海里。 Episteride (ONO-9302) 可用于前列腺增生和痤疮的研究。
  46. GC32934 Relugolix (TAK-385) A GnRH receptor antagonist
  47. GC32908 UT-155 UT-155是一种选择性的、有效的雄激素受体(AR)拮抗剂，与AR-LBD结合的Ki值为267nM。
  48. GC32907 N-desmethyl Enzalutamide (N-desmethyl MDV 3100) N-desMethyl EnzalutaMide (N-desmethyl MDV 3100) is the active metabolite of Enzalutamide, which is an oral androgen receptor inhibitor for treatment of castration-resistant prostate cancer.
  49. GC32843 Abarelix (R3827) Abarelix (R3827) (R3827; PPI 149) 是一种有效的促性腺激素释放激素 (GnRH) 拮抗剂，用于治疗前列腺癌。
  50. GC32817 AGN 193109 AGN193109是一种视黄酸类似物，是有效的，特异性的视黄酸受体(RARs)拮抗剂，可抑制RARα，RARβ和RARγ的活性，Kd值分别为2nM，2nM和3nM。
  51. GC32801 AZ876 An LXR agonist

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