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Urocortin (human) (trifluoroacetate salt) Sale

目录号 : GC45129

A neuropeptide hormone

Urocortin (human) (trifluoroacetate salt) Chemical Structure

规格 价格 库存 购买数量
500μg
¥2,998.00
现货
1mg
¥5,106.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Urocortin is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin II , urocortin III , frog sauvagine, and piscine urotensin I. Human urocortin shares 95% sequence homology with rat urocortin . Urocortin binds to type 1 and 2 CRF receptors as well as CRF binding protein (CRF-BP) with Ki values of 0.41, 1.8, 1.5, and 0.22 nM for human CRF1, rat CRF2α, mouse CRF2β, and human CRF-BP, respectively. It induces cAMP production in CHO cells expressing human CRF1, rat CRF2α, and mouse CRF2β receptors (EC50s = 0.22, 0.32, and 0.13 nM, respectively). Urocortin induces secretion of adrenocorticotropic hormone (ACTH) by rat anterior pituitary cells in a concentration-dependent manner, an effect that can be inhibited by human CRF-BP. It inhibits migration and proliferation of human vascular smooth muscle cells (VSMCs) and reduces LDL-induced foam cell formation in vitro. In vivo, urocortin slows development of aortic atherosclerotic lesions in Apoe-/- mice. Urocortin also decreases food intake in food-deprived and non-deprived rats as well as water intake in water-deprived rats in a dose-dependent manner.

Chemical Properties

Cas No. SDF
分子式 C204H337N63O64•XCF3COOH 分子量 4696.2
溶解度 Formic Acid: 1 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.2129 mL 1.0647 mL 2.1294 mL
5 mM 0.0426 mL 0.2129 mL 0.4259 mL
10 mM 0.0213 mL 0.1065 mL 0.2129 mL
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