Home >> Signaling Pathways >> Endocrinology and Hormones >> FXR & LXR


FXR (farnesoid X receptor) is a nuclear receptor that binds to hormone response elements on DNA, regulating the expression of certain genes when it is activated.

LXR (liver X receptor) is a member of the nuclear receptor family of transcription factors and is an important regulator of cholesterol, fatty acid, and glucose homeostasis.

  1. Cat.No. 产品名称 Information
  2. GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer)
  3. GC34965 (20S)-Protopanaxatriol An active ginsenoside metabolite
  4. GC14972 22(R)-hydroxy Cholesterol An endogenous agonist for LXRα
  5. GC18270 22(S)-hydroxy Cholesterol A synthetic oxysterol and LXR modulator
  6. GC17827 24(R)-hydroxy Cholesterol A synthetic enantiomer of a brain-derived oxysterol
  7. GC40571 24(S),25-epoxy Cholesterol An oxysterol
  8. GC18076 24(S)-hydroxy Cholesterol An agonist of LXR receptors
  9. GC33673 24-Hydroxycholesterol
  10. GC13431 24α-methyl Cholesterol A phytosterol
  11. GC13887 25(R)-27-hydroxy Cholesterol An endogenous agonist for LXR
  12. GC11700 25(S)-27-hydroxy Cholesterol An endogenous agonist for LXR
  13. GC40053 5α,6α-epoxy Cholestanol An oxysterol
  14. GC17059 Acetyl Podocarpic Acid Anhydride An endogenous LXR agonist
  15. GC40024 Altenusin A fungal metabolite with diverse biological activities
  16. GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

    An androgenic steroid

  17. GC32801 AZ876 An LXR agonist
  18. GC30565 BAR502 A dual agonist of GP-BAR1 and FXR
  19. GC42943 Bischloroanthrabenzoxocinone An inhibitor of FAS-II
  20. GC31372 BMS-779788 (EXEL04286652) An LXR agonist
  21. GC48426 CAY10771 A dual agonist of FXR and PPARδ
  22. GC17985 Chenodeoxycholic Acid A primary bile acid
  23. GC48424 Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide A metabolite of CDCA
  24. GC49853 Chenodeoxycholic Acid 3-Glucuronide A metabolite of CDCA
  25. GC48595 Chenodeoxycholic Acid MaxSpec® Standard A primary bile acid
  26. GC47076 Chenodeoxycholic Acid-d4 An internal standard for the quantification of chenodeoxycholic acid
  27. GC18212 Cilofexor An FXR ligand
  28. GC65260 EDP-305
  29. GC10755 Fexaramine A selective FXR agonist
  30. GC40911 Glycine-β-muricholic Acid

    An intestine-selective FXR antagonist

  31. GC45466 Glyco-Obeticholic Acid An active metabolite of obeticholic acid
  32. GC31331 GSK2033

    An antagonist of LXRα and LXRβ

  33. GC48610 GSK3987 A dual agonist of LXRα and LXRβ
  34. GC17658 Guggulsterone Guggulsterone 是一种植物甾醇,来自于 Commiphora wightii 的树胶树脂。 Guggulsterone 通过下调抗凋亡基因产物(IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP 和 survivin),调节细胞周期蛋白(cyclin D1 和c-Myc),激活半胱天冬酶和 JNK,抑制 Akt。 Guggulsterone 是一种法尼醇 X 受体 (FXR) 拮抗剂,可降低 CDCA 诱导的 FXR 活化,对 Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。
  35. GC16964 GW3965 An orally-active agonist of LXRα and LXRβ
  36. GC17696 GW3965 HCl An orally-active agonist of LXRα and LXRβ
  37. GC10975 GW4064 A potent, selective agonist of farnesoid X receptor
  38. GC32742 INT-767
  39. GC65936 Larsucosterol (trimethylamine)
  40. GC36499 LXRβ agonist-2
  41. GC13954 LXR-623 An LXR modulator
  42. GC19421 LY2562175 An FXR agonist
  43. GC31314 Nagilactone B
  44. GC34686 Nidufexor

    An FXR partial agonist

  45. GC14158 Obeticholic Acid Agonist of farnesoid X receptor (FXR)
  46. GC31395 PX20606 trans racemate (PX-102 trans racemate)
  47. GC19448 RGX-104 RGX-104 是一种小分子 LXR 激动剂,通过 ApoE 基因的转录激活来调节先天免疫。
  48. GC37525 RGX-104 free Acid
  49. GC32054 Rovazolac
  50. GN10024 Saikosaponin A A triterpenoid saponin with diverse biological activities
  51. GC37630 Sevelamer Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.

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