FXR & LXR
FXR (farnesoid X receptor) is a nuclear receptor that binds to hormone response elements on DNA, regulating the expression of certain genes when it is activated.
LXR (liver X receptor) is a member of the nuclear receptor family of transcription factors and is an important regulator of cholesterol, fatty acid, and glucose homeostasis.
Products for FXR & LXR
- Cat.No. 产品名称 Information
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GC31386
(-)-PX20606 trans isomer ((-)-PX-102 trans isomer)
PX-20606手性,(-)-PX-102 trans isomer; (-)-PX-104
(-)-PX20606 trans isomer ((-)-PX-102 trans isomer) 是一种 FXR 激动剂,在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 18 和 29 nM。 -
GC34965
(20S)-Protopanaxatriol
20 (S)-原人参三醇; 20(S)-APPT; g-PPT
An active ginsenoside metabolite -
GC14972
22(R)-hydroxy Cholesterol
22(R)-羟基胆固醇,Narthesterol
An endogenous agonist for LXRα -
GC18270
22(S)-hydroxy Cholesterol
22(S)-羟基胆固醇,22β-hydroxy Cholesterol
A synthetic oxysterol and LXR modulator -
GC17827
24(R)-hydroxy Cholesterol
24-Epicerebrosterol
A synthetic enantiomer of a brain-derived oxysterol -
GC40571
24(S),25-epoxy Cholesterol
(24S)-24,25-环氧胆固醇,24(S)-24,25-EC
An oxysterol -
GC18076
24(S)-hydroxy Cholesterol
(3Β,24S)-胆甾-5-烯-3,24-二醇,Cerebrosterol
An agonist of LXR receptors -
GC33673
24-Hydroxycholesterol
24-羟基胆固醇
24-Hydroxycholesterol是一种天然的固醇类物质,是n-甲基-d-天门冬氨酸受体(NMDA)和转录因子LXR的激活剂。
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GC13431
24α-methyl Cholesterol
菜油甾醇; (24R)-5-Ergosten-3β-ol
A phytosterol -
GC13887
25(R)-27-hydroxy Cholesterol
27-羟基胆固醇
An endogenous agonist for LXR -
GC11700
25(S)-27-hydroxy Cholesterol
(25S)-26-hydroxy cholesterol
An endogenous agonist for LXR -
GC91680
4-Acetamido Antipyrine
4-AAAP,NSC 331807
4-Acetamido antipyrine (4-AAAP) is an active metabolite of the non-opioid analgesic and antipyretic prodrug metamizole . -
GC40053
5α,6α-epoxy Cholestanol
胆固醇-5Α,6Α-环氧化物,NSC 18176
An oxysterol -
GC17059
Acetyl Podocarpic Acid Anhydride
APD
An endogenous LXR agonist -
GC40024
Altenusin
细格菌素,Alutenusin
A fungal metabolite with diverse biological activities -
GC30842
Androsterone (5α-Androstan-3α-ol-17-one)
雄酮; 5α-Androstan-3α-ol-17-one
An androgenic steroid
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GC32801
AZ876
2-叔丁基-5-苯基-4-[[4-(1-哌啶基)苯基]氨基]-3(2H)-异噻唑啉酮1,1-二氧化物
An LXR agonist - GC30565 BAR502 A dual agonist of GP-BAR1 and FXR
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GC42943
Bischloroanthrabenzoxocinone
BABX, (―)-Bischloroanthrabenzoxocinone
An inhibitor of FAS-II -
GC31372
BMS-779788 (EXEL04286652)
EXEL04286652; XL-652; BMS-788
An LXR agonist - GC48426 CAY10771 A dual agonist of FXR and PPARδ
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GC17985
Chenodeoxycholic Acid
鹅去氧胆酸
A primary bile acid -
GC48424
Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide
鹅去氧胆酸24-酰基-Β-D-葡糖苷酸
A metabolite of CDCA -
GC49853
Chenodeoxycholic Acid 3-Glucuronide
CDCA-3G, CDCA-3-Glucuronide
A metabolite of CDCA -
GC48595
Chenodeoxycholic Acid MaxSpec® Standard
鹅去氧胆酸; CDCA
A primary bile acid -
GC68212
Chenodeoxycholic acid-13C
CDCA-13C
Chenodeoxycholic acid-13C (CDCA-13C) 是一种 13C 标记的 Chenodeoxycholic Acid。Chenodeoxycholic Acid 是一种疏水初级胆汁酸,能够活化核受体 FXR,该受体与胆固醇代谢有关。 -
GC47076
Chenodeoxycholic Acid-d4
鹅去氧胆2,2,4,4-D4酸,CDCA-d4
An internal standard for the quantification of chenodeoxycholic acid -
GC18212
Cilofexor
GS-9674
An FXR ligand -
GC90700
Dendrogenin A
DDA
一种选择性的LXR调节剂和ChEH抑制剂。
- GC65260 EDP-305 EDP-305 是一种口服有效且选择性的 farnesoid X 受体 (FXR) 激动剂,其 EC50 值为 34 nM (CHO 细胞嵌合性 FXR) 和 8 nM (HEK 细胞全长 FXR)。EDP-305 显示出强大而持久的抗纤维化作用。EDP-305 可用于原发性胆道胆管炎 (PBC) 和非酒精性脂肪性肝炎 (NASH) 研究。
- GC10755 Fexaramine A selective FXR agonist
- GC71185 FXR agonist 3 FXR agonist 3是一种通过激活FXR起作用的抗NASH药物。
- GC69138 FXR agonist 5 FXR agonist 5 (compound 1) 是一种 FXR 激动剂。FXR agonist 5 可用于研究代谢性炎症引起的疾病或紊乱。
- GC71156 FXR antagonist 1 FXR antagonist 1(化合物F6)是一种口服活性和选择性肠FXR拮抗剂(IC50=2.1μM)。
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GC40911
Glycine-β-muricholic Acid
Gly-MCA, GβMCA
An intestine-selective FXR antagonist
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GC45466
Glyco-Obeticholic Acid
奥贝胆酸杂质8
An active metabolite of obeticholic acid -
GC31331
GSK2033
An antagonist of LXRα and LXRβ
- GC48610 GSK3987 A dual agonist of LXRα and LXRβ
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GC17658
Guggulsterone
香胶甾酮; Z/E-Guggulsterone
Guggulsterone 是一种植物甾醇,来自于 Commiphora wightii 的树胶树脂。 Guggulsterone 通过下调抗凋亡基因产物(IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP 和 survivin),调节细胞周期蛋白(cyclin D1 和c-Myc),激活半胱天冬酶和 JNK,抑制 Akt。 Guggulsterone 是一种法尼醇 X 受体 (FXR) 拮抗剂,可降低 CDCA 诱导的 FXR 活化,对 Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。 -
GC16964
GW3965
3-[3-[[[2-氯-3-(三氟甲基)苯基]甲基](2,2-联苯基乙基)氨基]丙氧基]苯乙酸盐酸盐,GW 3965;GW-3965
An orally-active agonist of LXRα and LXRβ -
GC17696
GW3965 HCl
2-[3-[3-[[2-氯-3-(三氟甲基)苄基](2,2-二苯基乙基)氨基]丙氧基]苯基]乙酸盐酸盐
An orally-active agonist of LXRα and LXRβ -
GC10975
GW4064
3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑
GW4064作为合成的FXR激动剂,用于治疗胆汁淤积性肝病、代谢综合征和酒精性肝病。 - GC32742 INT-767 INT-767是法尼醇X受体/TGR5双激动剂,平均EC50分别为30和630nM。
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GC65936
Larsucosterol (trimethylamine)
DUR-928 (trimethylamine)
Larsucosterol (DUR-928) trimethylamine 是一种胆固醇代谢物,是一种有效的肝 X 受体 (LXR) 拮抗剂。Larsucosterol trimethylamine 是一种有效的内源性脂肪生成调节剂。Larsucosterol trimethylamine 通过降低 mRNA 水平和抑制 SREBP-1 的激活抑制胆固醇的生物合成。 - GC36499 LXRβ agonist-2 LXRβ agonist-2 是一种高效 β 选择性肝 X 受体 (LXRβ) 激动剂,EC50为 7 nM,其选择性是 LXRα (EC50=200 nM) 的 28.5 倍,用于治疗动脉粥样硬化。
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GC13954
LXR-623
2-[(2-氯-4-氟苯基)甲基]-3-(4-氟苯基)-7-(三氟甲基)-2H-吲唑,WAY 252623
An LXR modulator - GC19421 LY2562175 An FXR agonist
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GC31314
Nagilactone B
竹柏内酯 B
NagilactoneB,是从Podocarpusnagi根皮中提取的,是一种肝X受体(LXR)激动剂。
- GC69541 NDB NDB 是一种选择性人 FXRα (hFXRα) 拮抗剂,可有效调节 FXRα 下游基因的转录。NDB可用于抗糖尿病研究。
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GC34686
Nidufexor
LMB763
An FXR partial agonist