FXR & LXR
FXR (farnesoid X receptor) is a nuclear receptor that binds to hormone response elements on DNA, regulating the expression of certain genes when it is activated.
LXR (liver X receptor) is a member of the nuclear receptor family of transcription factors and is an important regulator of cholesterol, fatty acid, and glucose homeostasis.
- Cat.No. 产品名称 Information
-
GC31386
(-)-PX20606 trans isomer ((-)-PX-102 trans isomer)
(-)-PX20606 trans isomer ((-)-PX-102 trans isomer) 是一种 FXR 激动剂,在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 18 和 29 nM。
-
GC34965
(20S)-Protopanaxatriol
An active ginsenoside metabolite
-
GC14972
22(R)-hydroxy Cholesterol
An endogenous agonist for LXRα
-
GC18270
22(S)-hydroxy Cholesterol
A synthetic oxysterol and LXR modulator
-
GC17827
24(R)-hydroxy Cholesterol
A synthetic enantiomer of a brain-derived oxysterol
-
GC40571
24(S),25-epoxy Cholesterol
An oxysterol
-
GC18076
24(S)-hydroxy Cholesterol
An agonist of LXR receptors
-
GC33673
24-Hydroxycholesterol
24-Hydroxycholesterol是一种天然的固醇类物质,是n-甲基-d-天门冬氨酸受体(NMDA)和转录因子LXR的激活剂。
-
GC13431
24α-methyl Cholesterol
A phytosterol
-
GC13887
25(R)-27-hydroxy Cholesterol
An endogenous agonist for LXR
-
GC11700
25(S)-27-hydroxy Cholesterol
An endogenous agonist for LXR
-
GC40053
5α,6α-epoxy Cholestanol
An oxysterol
-
GC17059
Acetyl Podocarpic Acid Anhydride
An endogenous LXR agonist
-
GC40024
Altenusin
A fungal metabolite with diverse biological activities
-
GC30842
Androsterone (5α-Androstan-3α-ol-17-one)
An androgenic steroid
-
GC32801
AZ876
An LXR agonist
-
GC30565
BAR502
A dual agonist of GP-BAR1 and FXR
-
GC42943
Bischloroanthrabenzoxocinone
An inhibitor of FAS-II
-
GC31372
BMS-779788 (EXEL04286652)
An LXR agonist
-
GC48426
CAY10771
A dual agonist of FXR and PPARδ
-
GC17985
Chenodeoxycholic Acid
A primary bile acid
-
GC48424
Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide
A metabolite of CDCA
-
GC49853
Chenodeoxycholic Acid 3-Glucuronide
A metabolite of CDCA
-
GC48595
Chenodeoxycholic Acid MaxSpec® Standard
A primary bile acid
-
GC68212
Chenodeoxycholic acid-13C
Chenodeoxycholic acid-13C (CDCA-13C) 是一种 13C 标记的 Chenodeoxycholic Acid。Chenodeoxycholic Acid 是一种疏水初级胆汁酸,能够活化核受体 FXR,该受体与胆固醇代谢有关。
-
GC47076
Chenodeoxycholic Acid-d4
An internal standard for the quantification of chenodeoxycholic acid
-
GC18212
Cilofexor
An FXR ligand
-
GC65260
EDP-305
EDP-305 是一种口服有效且选择性的 farnesoid X 受体 (FXR) 激动剂,其 EC50 值为 34 nM (CHO 细胞嵌合性 FXR) 和 8 nM (HEK 细胞全长 FXR)。EDP-305 显示出强大而持久的抗纤维化作用。EDP-305 可用于原发性胆道胆管炎 (PBC) 和非酒精性脂肪性肝炎 (NASH) 研究。
-
GC10755
Fexaramine
A selective FXR agonist
-
GC69138
FXR agonist 5
FXR agonist 5 (compound 1) 是一种 FXR 激动剂。FXR agonist 5 可用于研究代谢性炎症引起的疾病或紊乱。
-
GC40911
Glycine-β-muricholic Acid
An intestine-selective FXR antagonist
-
GC45466
Glyco-Obeticholic Acid
An active metabolite of obeticholic acid
-
GC31331
GSK2033
An antagonist of LXRα and LXRβ
-
GC48610
GSK3987
A dual agonist of LXRα and LXRβ
-
GC17658
Guggulsterone
Guggulsterone 是一种植物甾醇,来自于 Commiphora wightii 的树胶树脂。 Guggulsterone 通过下调抗凋亡基因产物(IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP 和 survivin),调节细胞周期蛋白(cyclin D1 和c-Myc),激活半胱天冬酶和 JNK,抑制 Akt。 Guggulsterone 是一种法尼醇 X 受体 (FXR) 拮抗剂,可降低 CDCA 诱导的 FXR 活化,对 Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。
-
GC16964
GW3965
An orally-active agonist of LXRα and LXRβ
-
GC17696
GW3965 HCl
An orally-active agonist of LXRα and LXRβ
-
GC10975
GW4064
A potent, selective agonist of farnesoid X receptor
-
GC32742
INT-767
INT-767是法尼醇X受体/TGR5双激动剂,平均EC50分别为30和630nM。
-
GC65936
Larsucosterol (trimethylamine)
Larsucosterol (DUR-928) trimethylamine 是一种胆固醇代谢物,是一种有效的肝 X 受体 (LXR) 拮抗剂。Larsucosterol trimethylamine 是一种有效的内源性脂肪生成调节剂。Larsucosterol trimethylamine 通过降低 mRNA 水平和抑制 SREBP-1 的激活抑制胆固醇的生物合成。
-
GC36499
LXRβ agonist-2
LXRβ agonist-2 是一种高效 β 选择性肝 X 受体 (LXRβ) 激动剂,EC50为 7 nM,其选择性是 LXRα (EC50=200 nM) 的 28.5 倍,用于治疗动脉粥样硬化。
-
GC13954
LXR-623
An LXR modulator
-
GC19421
LY2562175
An FXR agonist
-
GC31314
Nagilactone B
NagilactoneB,是从Podocarpusnagi根皮中提取的,是一种肝X受体(LXR)激动剂。
-
GC69541
NDB
NDB 是一种选择性人 FXRα (hFXRα) 拮抗剂,可有效调节 FXRα 下游基因的转录。NDB可用于抗糖尿病研究。
-
GC34686
Nidufexor
An FXR partial agonist
-
GC14158
Obeticholic Acid
Agonist of farnesoid X receptor (FXR)
-
GC31395
PX20606 trans racemate (PX-102 trans racemate)
PX20606 trans racemate (PX-102 trans racemate) (PX-102 trans racemate) 是一种 FXR 激动剂,在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 32 和 34 nM。
-
GC19448
RGX-104
RGX-104 是一种小分子 LXR 激动剂,通过 ApoE 基因的转录激活来调节先天免疫。
-
GC37525
RGX-104 free Acid
RGX-104 free Acid 是具有口服生物活性的、有效的肝X核激素受体 (LXRβ) 激动剂,通过ApoE基因的转录激活调节先天免疫。