FXR & LXR
FXR (farnesoid X receptor) is a nuclear receptor that binds to hormone response elements on DNA, regulating the expression of certain genes when it is activated.
LXR (liver X receptor) is a member of the nuclear receptor family of transcription factors and is an important regulator of cholesterol, fatty acid, and glucose homeostasis.
- Cat.No. 产品名称 Information
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GC31386
(-)-PX20606 trans isomer ((-)-PX-102 trans isomer)
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GC34965
(20S)-Protopanaxatriol
An active ginsenoside metabolite
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GC14972
22(R)-hydroxy Cholesterol
An endogenous agonist for LXRα
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GC18270
22(S)-hydroxy Cholesterol
A synthetic oxysterol and LXR modulator
-
GC17827
24(R)-hydroxy Cholesterol
A synthetic enantiomer of a brain-derived oxysterol
-
GC40571
24(S),25-epoxy Cholesterol
An oxysterol
-
GC18076
24(S)-hydroxy Cholesterol
An agonist of LXR receptors
-
GC33673
24-Hydroxycholesterol
-
GC13431
24α-methyl Cholesterol
A phytosterol
-
GC13887
25(R)-27-hydroxy Cholesterol
An endogenous agonist for LXR
-
GC11700
25(S)-27-hydroxy Cholesterol
An endogenous agonist for LXR
-
GC40053
5α,6α-epoxy Cholestanol
An oxysterol
-
GC17059
Acetyl Podocarpic Acid Anhydride
An endogenous LXR agonist
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GC40024
Altenusin
A fungal metabolite with diverse biological activities
-
GC30842
Androsterone (5α-Androstan-3α-ol-17-one)
An androgenic steroid
-
GC32801
AZ876
An LXR agonist
-
GC30565
BAR502
A dual agonist of GP-BAR1 and FXR
-
GC42943
Bischloroanthrabenzoxocinone
An inhibitor of FAS-II
-
GC31372
BMS-779788 (EXEL04286652)
An LXR agonist
-
GC48426
CAY10771
A dual agonist of FXR and PPARδ
-
GC17985
Chenodeoxycholic Acid
A primary bile acid
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GC48424
Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide
A metabolite of CDCA
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GC49853
Chenodeoxycholic Acid 3-Glucuronide
A metabolite of CDCA
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GC48595
Chenodeoxycholic Acid MaxSpec® Standard
A primary bile acid
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GC47076
Chenodeoxycholic Acid-d4
An internal standard for the quantification of chenodeoxycholic acid
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GC18212
Cilofexor
An FXR ligand
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GC65260
EDP-305
-
GC10755
Fexaramine
A selective FXR agonist
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GC40911
Glycine-β-muricholic Acid
An intestine-selective FXR antagonist
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GC45466
Glyco-Obeticholic Acid
An active metabolite of obeticholic acid
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GC31331
GSK2033
An antagonist of LXRα and LXRβ
-
GC48610
GSK3987
A dual agonist of LXRα and LXRβ
-
GC17658
Guggulsterone
Guggulsterone 是一种植物甾醇,来自于 Commiphora wightii 的树胶树脂。 Guggulsterone 通过下调抗凋亡基因产物(IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP 和 survivin),调节细胞周期蛋白(cyclin D1 和c-Myc),激活半胱天冬酶和 JNK,抑制 Akt。 Guggulsterone 是一种法尼醇 X 受体 (FXR) 拮抗剂,可降低 CDCA 诱导的 FXR 活化,对 Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。
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GC16964
GW3965
An orally-active agonist of LXRα and LXRβ
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GC17696
GW3965 HCl
An orally-active agonist of LXRα and LXRβ
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GC10975
GW4064
A potent, selective agonist of farnesoid X receptor
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GC32742
INT-767
-
GC65936
Larsucosterol (trimethylamine)
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GC36499
LXRβ agonist-2
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GC13954
LXR-623
An LXR modulator
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GC19421
LY2562175
An FXR agonist
-
GC31314
Nagilactone B
-
GC34686
Nidufexor
An FXR partial agonist
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GC14158
Obeticholic Acid
Agonist of farnesoid X receptor (FXR)
-
GC31395
PX20606 trans racemate (PX-102 trans racemate)
-
GC19448
RGX-104
RGX-104 是一种小分子 LXR 激动剂,通过 ApoE 基因的转录激活来调节先天免疫。
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GC37525
RGX-104 free Acid
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GC32054
Rovazolac
-
GN10024
Saikosaponin A
A triterpenoid saponin with diverse biological activities
-
GC37630
Sevelamer
Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.