FXR & LXR

FXR (farnesoid X receptor) is a nuclear receptor that binds to hormone response elements on DNA, regulating the expression of certain genes when it is activated.

LXR (liver X receptor) is a member of the nuclear receptor family of transcription factors and is an important regulator of cholesterol, fatty acid, and glucose homeostasis.

Products for FXR & LXR

Cat.No. 产品名称 Information
GC34686 Nidufexor
LMB763

An FXR partial agonist
GC14158 Obeticholic Acid
奥贝胆酸; INT-747; 6-ECDCA; 6-Ethylchenodeoxycholic acid
Obeticholic Acid（奥贝胆酸；INT-747；6-ECDCA；6-Ethylchenodeoxycholic acid）是一种有效的，选择性的和口服活性的法尼醇X受体（FXR ）激动剂，EC₅₀为99nM。
GC70996 Omesdafexor Omesdafexor是一种FXR激动剂。
GC31395 PX20606 trans racemate (PX-102 trans racemate)
CPDD1220反式消旋体,PX-102 trans racemate
PX20606 trans racemate (PX-102 trans racemate) (PX-102 trans racemate) 是一种 FXR 激动剂，在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 32 和 34 nM。
GC37525 RGX-104 free Acid
Abequolixron
RGX-104 free Acid 是具有口服生物活性的、有效的肝X核激素受体 (LXRβ) 激动剂，通过ApoE基因的转录激活调节先天免疫。
GC19448 RGX-104 Hydrochloride
Abequolixron hydrochloride
RGX-104 Hydrochloride是一种具口服活性的肝X受体（Liver X Receptor, LXR）激动剂，能够通过载脂蛋白E（ApoE）基因的转录激活调节先天免疫。
GC32054 Rovazolac
乙基2-[5-[3'-(甲基磺酰基)联苯基-4-基]-3-(三氟甲基)-1H-吡唑-1-基]乙酸酯
Rovazolac是从来自专利WO2013130892A1中的肝脏x受体(liverxreceptor(LXR))调节剂。
GN10024 Saikosaponin A
柴胡皂苷 A
A triterpenoid saponin with diverse biological activities
GC37630 Sevelamer
司维拉姆
Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
GC11885 Sevelamer HCl
盐酸司维拉姆
Sevelamer HCl 是一种磷酸盐结合药物，用于治疗慢性肾病患者的高磷血症；由与环氧氯丙烷交联的聚烯丙胺组成。
GC19892 Sodium chenodeoxycholate
鹅脱氧胆酸钠
A primary bile acid
GC45567 SR 1903 A modulator of RORγ and LXR receptors
GC13680 SR-9243 An LXR inverse agonist
GC14638 SR9238 A liver-specific inverse agonist of LXR
GC10596 T0901317
N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺
T0901317是一种口服活性高选择性LXR激动剂，对LXRα的EC₅₀为15nM，并能激活异生物质受体孕烷X受体(PXR)，EC₅₀为23nM。
GC44999 Tauro-α-muricholic Acid (sodium salt)
Tauro-α-muricholate, TαMCA
An FXR receptor antagonist
GC49011 Tauro-α-muricholic Acid-d4 (sodium salt) An internal standard for the quantification of tauro-α-muricholic acid
GC45000 Tauro-β-muricholic Acid (sodium salt)
牛磺-Α-鼠胆酸,Tauro-β-muricholate； TβMCA
Tauro-β-muricholic Acid (sodium salt)是一种可逆的竞争性法尼基X受体（FXR）拮抗剂（IC₅₀ = 40μM)。
GC49012 Tauro-β-muricholic Acid-d4 (sodium salt)
Tauro-β-muricholate-d4, TβMCA-d4
tauro-β-muricholic acid 定量的内标
GC45806 Tauro-ω-muricholic Acid (sodium salt)
T-ω-MCA, TOMCA
具有多种生物活性的神经肽
GC44998 Tauro-Obeticholic Acid
奥贝胆酸杂质9
An active metabolite of obeticholic acid
GC91042 Tauro-Obeticholic Acid (sodium salt)
Obeticholic Acid Taurine Conjugate, Tauro-OCA, Tauro-6-Ethyl-CDCA, Tauro-6-Ethylchenodeoxycholic Acid, T-ECDCA

一种欧贝替胆酸的活性代谢物。
GC19363 Tropifexor
LJN452
An FXR agonist
GC32459 XL041 (BMS-852927)
BMS-852927
XL041 (BMS-852927) (BMS-852927) 是一种 LXRβ-选择性激动剂。
GC10760 XL335
3-(3,4-二氟苯甲酰基)-1,2,3,6-四氢-1,1-二甲基氮杂卓[4,5-B]吲哚-5-甲酸1-甲基乙基酯,FXR-450; XL335; WAY-362450
A potent and selective FXR agonist
GC39535 Yamogenin
雅姆皂甙元; Neodiosgenin
A steroidal sapogenin with diverse biological activities
GC91037 ZLY28
一种FXR激动剂和FABP1抑制剂。