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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome(泛素化/蛋白酶体)

  1. Cat.No. 产品名称 Information
  2. GC16436 Tenovin-6 A small molecule activator of p53
  3. GC12021 GDC-0349

    N-ETHYL-N'-[4-[5,6,7,8-四氢-4-[(3S)-3-甲基-4-吗啉基]-7-(3-氧杂环丁基)吡啶并[3,4-D]嘧啶-2-基]苯基]脲

     A potent inhibitor of mTOR
  4. GC14920 VX-661

    VX-661

     An investigational compound that promotes the maturation of delta F508 CFTR
  5. GC10944 Butein

    紫铆因; 2’,3,4,4’-tetrahydroxy Chalcone

     A plant polyphenol
  6. GC11752 AZD5363

    4-氨基-N-[(1S)-1-(4-氯苯基)-3-羟基丙基]-1-(7H-吡咯并[2,3-D]嘧啶-4-基)-4-哌啶甲酰胺,AZD5363

     AZD5363是一种选择性抑制蛋白激酶Akt1、Akt2和Akt3的小分子化合物，IC₅₀值分别为3nM、7nM和7nM。AZD536靶向PI3K/Akt/mTOR信号通路，在多种癌症中显示出抗肿瘤活性。
  7. GC10359 GANT61

    2,2'-[[二氢-2-(4-吡啶基)-1,3(2H,4H)-嘧啶二基]二(亚甲基)]二[N,N-二甲基苯胺],NSC 136476

     GANT61 能够有效阻断 GLI1 和 GLI2 诱导的转录，IC50 为 5 μM。
  8. GC10395 Dynasore Dynasore 作为 GTPase 抑制剂，可以快速、可逆地抑制发动蛋白活性，从而阻止内吞作用。
  9. GC12843 MEK162 (ARRY-162, ARRY-438162)

    贝美替尼,MEK162; ARRY-162; ARRY-438162

     A MEK1/2 inhibitor
  10. GC10596 T0901317

    N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺

     Selective agonist for LXRα and LXRβ
  11. GC17295 10058-F4

    5-(4-乙基苯亚甲基)

     10058-F4是一种c-Myc抑制剂，抑制c-Myc-Max二聚化，阻止c-Myc靶基因表达的转录激活。
  12. GC11015 PD168393 An irreversible EGFR kinase inhibitor
  13. GC16380 AZD8055

    CCG-168

     AZD8055是一种新型的ATP竞争性mTOR抑制剂，IC50 为0.8 nmol/L，Ki为1.3 nmol/L。
  14. GC17615 Quizartinib (AC220)

    奎扎替尼; AC220

     An inhibitor of FLT3
  15. GC14289 Fasudil (HA-1077) HCl

    盐酸法舒地尔; HA-1077 Hydrochloride; AT-877 Hydrochloride

     Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的Ki为0.33μM，IC50为0.158μM，对ROCK2和PKA、PKC、PKG的IC50分别为4.58μM、12.30μM、1.650μM。
  16. GC11497 BIRB 796 (Doramapimod)

    达马莫德; BIRB 796

     A potent inhibitor of p38 MAPK
  17. GC16835 LY2228820

    5-[2-(叔丁基)-4-(4-氟苯基)-1H-咪唑-5-基]-3-(2,2-二甲基丙基)-3H-咪唑并[4,5-B]吡啶-2-胺甲磺酸盐,LY2228820 dimesylate

     A potent inhibitor of p38α MAP kinase
  18. GC16851 AZD6482

    2-[[(1R)-1-[7-甲基-2-(4-吗啉)-4-氧代-4H-吡啶并[1,2-A]嘧啶-9-基]乙基]氨基]苯甲酸,KIN-193

     A PI3Kβ inhibitor
  19. GC14574 Tigecycline

    替加环素; GAR-936

     A glycylcycline antibiotic
  20. GC15459 Tazarotene

    他扎罗汀; AGN 190168

     A retinoid prodrug
  21. GC14396 Ponatinib (AP24534)

    普纳替尼; AP24534

     An inhibitor of native and mutant Bcr-Abl
  22. GC12474 AS-605240

    5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮

     A potent inhibitor of PI3-kinase γ
  23. GC16868 Sulfasalazine

    柳氮磺吡啶; NSC 667219

     Sulfasalazine是一种磺胺类药物。
  24. GC13882 Ranolazine 2HCl

    盐酸雷诺嗪; CVT 303 dihydrochloride; RS 43285

     A piperazine derivative with cardioprotective activity
  25. GC18072 Prazosin HCl

    哌唑嗪盐酸盐

     An α1-adrenergic receptor antagonist
  26. GC15197 Saracatinib (AZD0530)

    塞卡替尼; AZD0530

     A dual inhibitor of c-Src and Abl
  27. GC11473 Irinotecan

    伊立替康; (+)-Irinotecan; CPT-11

     Irinotecan是一种拓扑异构酶抑制剂，主要用于治疗结直肠癌。Irinotecan可通过与拓扑异构酶 I-DNA 复合物结合，阻止 DNA 链的再连接，并导致 DNA 双链断裂和细胞死亡 。
  28. GC14701 Zoledronic Acid

    唑来膦酸; Zoledronate; CGP 42446; CGP42446A; ZOL 446

     A bisphosphonate that inhibits bone resorption
  29. GC14238 Brivanib Alaninate (BMS-582664)

    1-[[4-[(4-氟-2-甲基-1H-吲哚-5-基)氧基]-5-甲基吡咯并[2,1-F][1,2,4]三嗪-6-基]氧基]-2-丙醇L-丙氨酸酯,BMS-582664

     A prodrug form of brivanib
  30. GC12963 NVP-AEW541

    AEW541

     An IGF-1R inhibitor
  31. GC17094 Acitretin

    阿维A; Ro 10-1670

     A retinoid
  32. GC11692 Brivanib (BMS-540215)

    布立尼布; BMS-540215

     A VEGFR1, VEGFR2, and FGFR1 inhibitor
  33. GC10662 WYE-354

    4-[6-[4-[(甲氧羰基)氨基]苯基]-4-(4-吗啉基)-1H-吡唑并[3,4-D]嘧啶-1-基]-1-哌啶羧酸甲酯

     Potent inhibitor of mTOR in both mTORC1 and mTORC2
  34. GC13696 GSK690693

    4-[2-(4-氨基-1,2,5-恶二唑-3-基)-1-乙基-7-[(3S)-3-哌啶基甲氧基]-1H-咪唑并[4,5-C]吡啶-4-基]-2-甲基-3-丁炔-2-醇

     GSK690693 是一种 ATP 竞争性低纳摩尔 Akt 激酶抑制剂，对 Akt1、2 和 3 的 IC50 值分别为 2、13 和 9 nM。
  35. GC16421 Cediranib (AZD217)

    西地尼布; AZD2171

     An inhibitor of VEGF receptor tyrosine kinases
  36. GC13968 SB202190 (FHPI)

    4-(4-氟苯基)-2-(4-羟基苯基)-5-(4-吡啶基)-1H-咪唑

     SB 202190是一种选择性p38 MAP激酶抑制剂,对p38α和p38β2的IC50分别为50 nM和100 nM。
  37. GC11759 Imatinib Mesylate (STI571)

    甲磺酸伊马替尼; STI571 Mesylate; CGP-57148B Mesylate

     An inhibitor of c-Abl, Bcr-Abl, PDGFR, and c-Kit
  38. GC17958 Linifanib (ABT-869)

    利尼伐尼,ABT-869; AL-39324

     A dual VEGFR and PDGFR family kinase inhibitor
  39. GC11499 Enzastaurin (LY317615)

    恩扎妥林; LY317615

     An inhibitor of PKC and Akt signaling
  40. GC12271 Bicalutamide

    比卡鲁胺

     A non-steroidal antiandrogen
  41. GC14969 Idarubicin HCl

    盐酸伊达比星; 4-Demethoxydaunorubicin hydrochloride

     Antitumor antibiotic used in treatment of leukemia
  42. GC13697 AG-1024

    Tyrphostin AG 1024

     AG-1024是一种可逆的，竞争性和选择性的胰岛素样生长因子-1受体（IGF-1R）抑制剂，IC50值为7µM。AG-1024能够抑制胰岛素受体（IR）的磷酸化，IC50值为57µM。
  43. GC14667 Dexamethasone (DHAP) Glucocorticoidan;anti-inflammatory
  44. GC15742 OSU-03012 (AR-12)

    2-氨基-N-[4-[5-(2-菲基)-3-(三氟甲基)-1H-吡唑-1-基]苯基]乙酰胺

     An anti-cancer celecoxib analog
  45. GC10296 Ivacaftor (VX-770)

    依伐卡托; VX-770

     A CFTR potentiator
  46. GC15617 Etoposide

    依托泊苷; VP-16; VP-16-213

     Etoposide（VP-16）是一种非特异性拓扑异构酶II（Topoisomerase II）抑制剂，IC50值为59.2 μM。
  47. GC11709 Fluoxetine HCl

    盐酸氟西汀; LY 110140

     An Analytical Reference Material
  48. GC11089 SU11274

    N-(3-氯苯基)-N-甲基-3-[[3,5-二甲基-4-[(4-甲基哌嗪-1-基)羰基-1H-吡咯-2-基]亚甲基]-2-氧代-2,3-二氢-1H-吲哚-5-磺酰胺,PKI-SU11274

     A potent, selective inhibitor of c-Met
  49. GC13443 Doxazosin Mesylate

    甲磺酸多沙唑嗪; UK 33274 mesylate

     An α1-AR antagonist
  50. GC10610 Adapalene

    阿达帕林; CD271

     An RARβ and RARγ agonist
  51. GC11733 PHA-665752

    (2R)-1-[[5-[(Z)-[5-[[(2,6-二氯苯基)甲基]磺酰]-1,2-二氢-2-氧代-3H-吲哚-3-亚基]甲基]-2,4-二甲基-1H-吡咯-3-基]羰基]-2-(1-吡咯烷甲基)吡咯烷

     A selective c-Met inhibitor

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