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Doxazosin Mesylate Sale

(Synonyms: 甲磺酸多沙唑嗪; UK 33274 mesylate) 目录号 : GC13443

An α1-AR antagonist

Doxazosin Mesylate Chemical Structure

Cas No.:77883-43-3

规格 价格 库存 购买数量
10mM (in 1mL DMSO) 待询 待询
50mg 待询 待询
100mg
¥630.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Doxazosin Mesylate is a selective, long-lasting antagonist of α1-adrenergic receptor [1].

Doxazosin Mesylate has been reported to potentiate contraction response to 5-HT in a dose-dependent manner [1]. Doxazosin significantly reduced alcohol drinking and increased water intake in adult male P rats [2].

Studies has indicated that doxazosin could inhibit TNF-α expression in LPS-induced systemic inflammation model as well as reduce the MCP-1 production in LPS-induced pulmonary inflammation model. Additionally, Doxazosin decreased thickness of footpad in the delayed-type hypersensitivity mice model. Doxazosin had been reported to slightly reduce MCP-1 level in the peritoneal cavity of mice induced by thioglycollate [3].

References:
[1] Zhao Y1, Cao XB, Ren LM. Doxazosin selectively potentiates contraction to serotonin via 5-HT₂A receptors in longitudinal muscle strips of the rabbit gastric body. Can J Physiol Pharmacol. 2014 Mar;92(3):197-204.
[2] O'Neil ML1, Beckwith LE, Kincaid CL, Rasmussen DD. The α1-adrenergic receptor antagonist, doxazosin, reduces alcohol drinking in alcohol-preferring (P) Rats. Alcohol Clin Exp Res. 2013 Feb;37(2):202-12.
[3] Tung D1, Ciallella J, Cheung PH, Saha S. Novel anti-inflammatory effects of doxazosin in rodent models of inflammation. Pharmacology. 2013;91(1-2):29-34.

Chemical Properties

Cas No. 77883-43-3 SDF
别名 甲磺酸多沙唑嗪; UK 33274 mesylate
化学名 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone;methanesulfonic acid
Canonical SMILES COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC.CS(=O)(=O)O
分子式 C23H25N5O5.CH4O3S 分子量 547.58
溶解度 ≥ 13.7mg/mL in DMSO with gentle warming 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 1.8262 mL 9.1311 mL 18.2622 mL
5 mM 0.3652 mL 1.8262 mL 3.6524 mL
10 mM 0.1826 mL 0.9131 mL 1.8262 mL
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