Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> DUB


Deubiquitinating enzymes (DUBs), belonging to the superfamily of proteases, are a group of enzymes that catalyze the cleavage of ubiquitin from ubiquitin-linked molecules after the terminal carbonyl of the last residue of ubiquitin (Gly76). Based on the mechanism of catalysis, DUBs is divided into two classes, cysteine proteases, which interact with substrates through the thiol group of a cysteine in the active site, and metalloproteases, which form a noncovalent intermediate with the substrate through a Zn2+ bound polarized water molecule. The cysteine protease DUBs have different Ub-protease domains and hence are further divided into four subclasses, ubiquitin-specific protease (USP), ubiquitin C-terminal hydrolase (UCH), Otubain protease (OTU) and Machado-Joseph disease protease (MJD); while all metalloprotease DUBs have one Ub protease domain called JAMM (JAB1/MPN/Mov34 metalloenzyme).

Products for  DUB

  1. Cat.No. 产品名称 Information
  2. GC17912 C598-0466

    USP7 inhibitor

  3. GC10601 Ubiquitin Isopeptidase Inhibitor I An activator of caspases
  4. GC13892 C527 An inhibitor of the USP1/UAF complex
  5. GC12622 HBX 41108 An inhibitor of USP7
  6. GC10356 DUBs-IN-3 DUBs-IN-3 是一种有效的去泛素酶 (USP) 酶抑制剂,从参考化合物 22c 中提取,对 USP8 的 IC50 为 0.56 μM。
  7. GC17125 DUBs-IN-2 DUBs-IN-2 是一种有效的去泛素酶抑制剂,IC50 为 0.28 μM for USP8。
  8. GC13401 SJB3-019A SJB3-019A 是一种有效的新型 USP1 抑制剂,在促进 K562 细胞中 ID1 降解和细胞毒性方面的作用是 SJB2-043 的 5 倍,IC50 为 0.0781 μM。
  9. GC17635 ML-323 A selective USP1-UAF1 deubiquitinase complex inhibitor
  10. GC10970 WP1130 A deubiquitinase inhibitor
  11. GC13208 PR-619 PR-619是一种广谱的去泛素酶抑制剂。PR-619在HEK 293T细胞中表现出强大的DUB抑制活性(5-20µM)和生长抑制活性,IC50为2µM。.
  12. GC17269 Vialinin A

    A natural immunosuppressant from fungi

  13. GC17698 SJB2-043 An inhibitor of the USP1-UAF1 complex and SARS-CoV-2 PLpro
  14. GC12475 NSC 632839 hydrochloride A deubiquitylase and deSUMOylase inhibitor
  15. GC10510 LDN 57444 An inhibitor of UCH-L1
  16. GC14797 IU1 A deubiquitinating enzyme inhibitor
  17. GC12067 P005091 A selective inhibitor of ubiquitin-specific protease 7
  18. GC10379 P 22077 P 22077 是一种可渗透细胞的泛素特异性蛋白酶 7 (USP7) 抑制剂,EC50 为 8.01 μM。 P 22077 还抑制 USP47,EC50 为 8.74 μM。

17 Item(s)

per page

Set Descending Direction