DUB(去泛素化酶)
Deubiquitinating enzymes (DUBs), belonging to the superfamily of proteases, are a group of enzymes that catalyze the cleavage of ubiquitin from ubiquitin-linked molecules after the terminal carbonyl of the last residue of ubiquitin (Gly76). Based on the mechanism of catalysis, DUBs is divided into two classes, cysteine proteases, which interact with substrates through the thiol group of a cysteine in the active site, and metalloproteases, which form a noncovalent intermediate with the substrate through a Zn2+ bound polarized water molecule. The cysteine protease DUBs have different Ub-protease domains and hence are further divided into four subclasses, ubiquitin-specific protease (USP), ubiquitin C-terminal hydrolase (UCH), Otubain protease (OTU) and Machado-Joseph disease protease (MJD); while all metalloprotease DUBs have one Ub protease domain called JAMM (JAB1/MPN/Mov34 metalloenzyme).
- Cat.No. 产品名称 Information
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GC17912
C598-0466
USP7 inhibitor
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GC10601
Ubiquitin Isopeptidase Inhibitor I
An activator of caspases
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GC13892
C527
An inhibitor of the USP1/UAF complex
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GC12622
HBX 41108
An inhibitor of USP7
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GC10356
DUBs-IN-3
DUBs-IN-3 是一种有效的去泛素酶 (USP) 酶抑制剂,从参考化合物 22c 中提取,对 USP8 的 IC50 为 0.56 μM。
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GC17125
DUBs-IN-2
DUBs-IN-2 是一种有效的去泛素酶抑制剂,IC50 为 0.28 μM for USP8。
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GC13401
SJB3-019A
SJB3-019A 是一种有效的新型 USP1 抑制剂,在促进 K562 细胞中 ID1 降解和细胞毒性方面的作用是 SJB2-043 的 5 倍,IC50 为 0.0781 μM。
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GC17635
ML-323
A selective USP1-UAF1 deubiquitinase complex inhibitor
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GC10970
WP1130
A deubiquitinase inhibitor
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GC13208
PR-619
A general inhibitor of DUBs
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GC17269
Vialinin A
A natural immunosuppressant from fungi
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GC17698
SJB2-043
An inhibitor of the USP1-UAF1 complex and SARS-CoV-2 PLpro
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GC12475
NSC 632839 hydrochloride
A deubiquitylase and deSUMOylase inhibitor
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GC10510
LDN 57444
An inhibitor of UCH-L1
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GC14797
IU1
A deubiquitinating enzyme inhibitor
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GC12067
P005091
A selective inhibitor of ubiquitin-specific protease 7
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GC10379
P 22077
P 22077 是一种可渗透细胞的泛素特异性蛋白酶 7 (USP7) 抑制剂,EC50 为 8.01 μM。 P 22077 还抑制 USP47,EC50 为 8.74 μM。