E3 Ligase(E3 连接酶)
E3 ligases perform the last step in the ubiquitination cascade. They transfer the ubiquitin from the active site cysteine of E2 enzyme to the substrate lysine or N terminus. The loss of function or mis-targeting of the E3 ligases are associated with various cancer types.
- Cat.No. 产品名称 Information
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GC25019
5-amino-2,4-dimethylpyridine (5A-DMP)
5-amino-2,4-dimethylpyridine (5A-DMP) is a novel tandem Tudor domain (TTD)-binding compound that inhibits the full-length UHRF1:LIG1 interaction in Xenopus egg extracts
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GC50234
N106
An activator of SERCA2A sumoylation
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GC44291
NAB 2
An inhibitor of α-synuclein-induced toxicity
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GC10940
PRT 4165
An inhibitor of PRC1 ubiquitin ligases
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GC15492
SMER 3
A selective inhibitor of SCFMET30 ubiquitin E3 ligase
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GC11869
SZL P1-41
An inhibitor of Skp2
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GC15017
NSC 624206
An inhibitor of ubiquitin-activating enzyme (E1)