TGF-β / Smad Signaling(TGF-β / Smad 信号转导)
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).
TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.
Products for TGF-β / Smad Signaling
- Cat.No. 产品名称 Information
- GC19177 GSK180736A A ROCK1 and GRK2 inhibitor
- GC19034 AR-13324 mesylate AR-13324 是一种有效的 ROCK I 和 ROCK II 抑制剂,已被证明可在低浓度下诱导培养的人和猪 TM 细胞的形态学变化。
- GC18521 Cercosporin A cytotoxic phytotoxin
- GC18354 Bisindolylmaleimide X (hydrochloride) A PKC inhibitor
- GC18246 R-59-949 A DGK-α inhibitor
- GC14134 1,2-Dimyristoyl-sn-glycerol A long-chain DAG
- GC18062 1,2-Dilauroyl-sn-glycerol A long-chain DAG
- GC12662 1,2-Distearoyl-sn-glycerol A diacylglycerol
- GC16539 Butaprost A selective agonist for the EP2 receptors
- GC10299 Hexadecyl Methyl Glycerol A synthetic DAG
- GC16678 UCN-02 A PKC inhibitor
- GC13877 1,2-Dipalmitoyl-sn-glycerol A diacylglycerol
- GC17815 L-threo-Sphingosine C-18 A D-erythro-sphingosine analog
- GC13226 Bisindolylmaleimide VIII (acetate) A PKC inhibitor
- GC14716 Bisindolylmaleimide IV A PKC inhibitor
- GC10343 α-Amyloid Precursor Protein Modulator α-Amyloid Precursor Protein Modulator 是一种细胞可渗透的苯并内酰胺衍生蛋白激酶 C (PKC) 激活剂,Ki 为 11.9 nM。
- GC11050 ALK5 Inhibitor II (hydrochloride) A selective inhibitor of ALK5
- GC15018 Hispidin A polyphenol with diverse biological activities
- GC16405 Safingol A dual inhibitor of PKC and SPHK
- GC11022 SB 218078 A potent Chk1 inhibitor
- GC10716 Netarsudil (AR-13324) ROCK抑制剂
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GC17191
SIS3 HCl
SIS3HCl 是一种有效的选择性 Smad3 抑制剂,对 Smad3 磷酸化的 IC50 为 3 μM。
- GC13273 ZIP ZIP 是 PKMζ 的选择性肽抑制剂。
- GC17239 Bisindolylmaleimide V A S6K inhibitor
- GC10029 Ro 31-8220 methanesulfonate Inhibitor of protein kinase C
- GC10607 GNF-7 A multi-kinase inhibitor
- GC17901 Tamoxifen Tamoxifen(他莫西芬)是一种选择性雌激素受体调节剂 (SERM),可阻断乳腺细胞中的雌激素作用,并可激活不同组织细胞中的雌激素活性;Tamoxifen 还可以作为 Hsp90 激活剂,增强 Hsp90 分子伴侣 ATPase 的活性;Tamoxifen 还可以诱导 CreER(T2) 小鼠的基因敲除[1-4]。
- GC15884 Dasatinib Monohydrate An inhibitor of Abl and Src
- GC13354 EW-7197 A potent inhibitor of ALK5
- GC12402 LX7101 HCL A LIMK and ROCK inhibitor
- GC12108 ITD 1 An inhibitor of TGF-β
- GC11140 Radotinib(IY-5511) A selective Bcr-Abl tyrosine kinase inhibitor
- GC17242 (-)-epigallocatechin A green tea polyphenol
- GC10603 (-)-epicatechin gallate A natural polyphenol with diverse protective actions
- GC12695 Bryostatin 3 Bryostatin 3 是一种大环内酯,是一种蛋白激酶 C 激活剂,Ki 为 2.75 nM。 Bryostatin 3 可以阻断 12-O-tetradecanoylphorbol-13-acetate (TPA) 对细胞增殖的抑制作用,但不能阻断 TPA 增强的细胞-基质粘附。
- GC12842 Bryostatin 2 Protein kinase C (PKC) activator
- GC13759 SAR407899 A ROCK1 and ROCK2 inhibitor
- GC16289 SAR407899 hydrochloride A ROCK1 and ROCK2 inhibitor
- GC13225 LDN-214117 A selective ALK1 and ALK2 inhibitor
- GC16475 Afuresertib A pan-Akt inhibitor
- GC12817 K–115 hydrochloride dihydrate K-115 hydrochloride dihydrate (K-115) 是 ROCK 的特异性抑制剂,对 ROCK2 和 ROCK1 的 IC50 分别为 19 和 51 nM。
- GC14012 (-)-Indolactam V A PKC activator
- GC10682 TAS 301 An inhibitor of Ca2+ mobilization and CaM kinase II
- GC15057 Kartogenin A potent inducer of chondrocyte differentiation
- GC15170 SB 772077B dihydrochloride A ROCK1 and ROCK2 inhibitor
- GC12135 Bisindolylmaleimide II A PKC inhibitor
- GC14583 R 59-022 A DGK inhibitor
- GC10820 Rottlerin An inhibitor of PKCδ and other protein kinases
- GC11605 C-1 C-1 是一种有效的蛋白激酶抑制剂,IC50 为 4 μM, 8 μM, 12 μM 和 240 μM 用于 cGMP 依赖性蛋白激酶 (PKG)、cAMP 依赖性蛋白激酶 (PKA) ,分别为蛋白激酶 C (PKC) 和 MLC 激酶。 C-1 也用作 ROCK 抑制剂。
- GC18055 SC-9 An activator of PKC