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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome(泛素化/蛋白酶体)

  1. Cat.No. 产品名称 Information
  2. GC19569 Hydroquinone
  3. GC48124 Tamoxifen-d5 An internal standard for the quantification of tamoxifen
  4. GC48118 Sunitinib-d10 An internal standard for the quantification of sunitinib
  5. GC48052 Rilmenidine-d4 An internal standard for the quantification of rilmenidine
  6. GC48027 Rapamycin-d3 An internal standard for the quantification of rapamycin
  7. GC47965 Pomalidomide-d5 An internal standard for the quantification of pomalidomide
  8. GC47735 N-acetyl Desethylchloroquine-d4 An internal standard for the quantification of N-acetyl desethylchloroquine
  9. GC47445 Hydroxychloroquine-d4 (sulfate) An internal standard for the quantification of hydroxychloroquine
  10. GC47436 HT-2 Toxin-13C22 An internal standard for the quantification of HT-2 toxin
  11. GC47408 Glycochenodeoxycholic Acid-d4 An internal standard for the quantification of glycochenodeoxycholic acid
  12. GC47303 Erlotinib-d6 (hydrochloride) An internal standard for the quantification of erlotinib
  13. GC47271 D-Pyrohomoglutamic Acid A building block
  14. GC47195 Desethylchloroquine-d4 An internal standard for the quantification of desethylchloroquine
  15. GC47194 Desethylchloroquine An active metabolite of chloroquine
  16. GC47193 Desethyl Hydroxychloroquine-d4 An internal standard for the quantification of desethyl hydroxychloroquine
  17. GC47065 CAY10773 A derivative of sorafenib
  18. GC47042 Carfilzomib-d8 An internal standard for the quantification of carfilzomib
  19. GC46923 Bexarotene-d4 A neuropeptide with diverse biological activities
  20. GC46897 AUTEN-99 An inhibitor of MRMR14/Jumpy
  21. GC61263 Salvigenin A polyphenol flavonoid with diverse biological activities
  22. GC61256 Rupatadine D4 fumarate RupatadineD4fumarate(UR-12592D4fumarate)是Rupatadinefumarate的氘代标记物。RupatadineFumarate(UR-12592Fumarate)富马酸盐是PAF/H1受体双抑制剂，Ki值分别为0.55μM和0.1μM。
  23. GC61251 Rosuvastatin D3 RosuvastatinD3(ZD4522D3)是Rosuvastatin的一种氘代化合物。Rosuvastatin(ZD4522)是一种竞争性HMG-CoA还原酶抑制剂，IC50为11nM。Rosuvastatin有效阻断人类醚-a-go-go相关基因(hERG)电流，IC50为195nM，延迟心脏复极化，从而延长动作电位持续时间(APDs)和校正QT间期(QTc)间隔。
  24. GC61229 Quinacrine dihydrochloride Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.
  25. GC61227 Quercetin D5 QuercetinD5是Quercetin的一种氘代化合物。Quercetin是一种天然黄酮类化合物，可激活或抑制许多蛋白质的活性。Quercetin可激活SIRT1，也可抑制PI3K，抑制PI3Kγ，PI3Kδ，PI3Kβ的IC50分别为2.4μM,3.0μM,5.4μM。
  26. GC61221 PTP1B-IN-9 An inhibitor of the ubiquitin-proteasome system
  27. GC61183 Physalin B PhysalinB是Capegooseberry中主要的甾体活性成分之一，通过调节p53依赖的凋亡途径，诱导乳腺癌细胞周期阻滞和诱导凋亡(apoptosis)。PhysalinB抑制人结肠癌细胞泛素-蛋白酶体通路并诱导不完全自噬反应。
  28. GC61155 Omeprazole sodium An irreversible inhibitor of the gastric proton pump
  29. GC61045 Metformin D6 hydrochloride An internal standard for the quantification of metformin
  30. GC61003 Loperamide D6 hydrochloride LoperamideD6hydrochloride(R-18553D6hydrochloride)是Loperamidehydrochloride的氘代化合物。Loperamidehydrochloride是一种阿片受体(opioidreceptor)的激动剂，可用于腹泻的研究。
  31. GC60935 Indomethacin sodium hydrate A non-selective COX inhibitor
  32. GC60930 Imatinib D4 ImatinibD4(STI571D4)是Imatinib(STI571)的氘代物。Imatinib是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制BCR/ABL，v-Abl，PDGFR，c-kit激酶活性。
  33. GC60891 GW406108X GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
  34. GC60882 Glyphosate An herbicide
  35. GC60868 Gefitinib D8 GefitinibD8(ZD1839D8)是Gefitinib的氘代物。Gefitinib是一种有效的(EGFR)抑制剂，在NR6wtEGFR细胞中IC50值为2-37nM。
  36. GC60826 Etoposide phosphate Etoposidephosphate(BMY-40481)是一种有效的抗癌(anti-cancer)化疗试剂和一种选择性拓扑异构酶II(topoisomeraseII)抑制剂，可以防止DNA链的重新连接。Etoposidephosphate是依托泊苷的磷酸酯前药，被认为与Etoposide活性相当。Etoposidephosphate诱导细胞周期阻滞、凋亡(apoptosis)和自噬(autophagy)。
  37. GC60700 Chloroquine D5 An internal standard for the quantification of chloroquine
  38. GC60688 Cereblon modulator 1 A modulator of cereblon
  39. GC60668 Calcimycin hemimagnesium Calcimycin(A-23187)hemimagnesium是一种抗生素和独特的二价阳离子离子载体(divalentcationionophore)，如钙离子和镁离子。Calcimycinhemimagnesium通过增加细胞内钙浓度诱导Ca2+依赖性细胞死亡。Calcimycinhemimagnesium抑制革兰氏阳性细菌和一些真菌的生长，还抑制ATP酶的活性并解耦哺乳动物细胞的氧化磷酸化(OXPHOS)，诱导细胞凋亡(apoptosis)。
  40. GC60567 Afatinib impurity 11 Afatinib impurity 11 is an impurity of afatinib, an EGFR family inhibitor.
  41. GC60395 (3S,5R)-Fluvastatin D6 (3S,5R)-FluvastatinD6是(3S,5R)-Fluvastatinsodium的氘代物。Fluvastatin是第一个完全合成的，竞争性的HMG-CoAreductase还原酶抑制剂，IC50为8nM。Fluvastatin通过依赖Nrf2的抗氧化通路保护血管平滑肌细胞免受氧化应激。
  42. GC60325 Rilmenidine An antihypertensive agent
  43. GC60257 MSC1094308 MSC1094308 是一种可逆的、II 型 AAA ATPase (VCP)/p97 和I型 AAA ATPase VPS4B 的变构抑制剂，对VPS4B 和 p97 的IC50 值分别为 0.71 μM 和 7.2 μM。
  44. GC60245 Metformin

    二甲双胍（Metformin 1,1-二甲基双胍）主要介导AMPK的激活，AMPK是一种参与调节细胞能量代谢的丝氨酸/苏氨酸蛋白激酶，导致癌细胞mTOR信号和蛋白质合成的减少。
  45. GC60241 Melatonin D5 An internal standard for the quantification of melatonin
  46. GC60159 Ezetimibe ketone Ezetimibe ketone (EZM-K) 是 Ezetimibe 的 I 期代谢产物。Ezetimibe 是一种 NPC1L1 抑制剂，是有效的 Nrf2 激活剂，Ezetimibe 还是有效的胆固醇吸收抑制剂。
  47. GC60076 Bigelovin Bigelovin是可从海百合中分离得到的一种倍半萜内酯，是选择性的视黄素X受体α(retinoidXreceptorα)的激动剂。Bigelovin可通过诱导凋亡和自噬来发挥抗肿瘤活性。Bigelovin通过抑制ROS的生成来调节mTOR信号通路。
  48. GC39658 4,4'-Dimethoxychalcone 4,4'-Dimethoxychalcone 可从植物当归中分离得到，是一种天然自噬 (autophagy) 诱导剂，具有抗衰老活性。
  49. GC39612 Imatinib D8 Imatinib D8 (STI571 D8) 是 Imatinib (STI571) 的氘代物。Imatinib 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。
  50. GC39530 TFEB activator 1 A synthetic curcuminoid and activator of TFEB
  51. GC39481 BL-918 An ULK1 activator

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