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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome(泛素化/蛋白酶体)

  1. Cat.No. 产品名称 Information
  2. GC35555 Britannin Britannin，分离于 Inula aucheriana，是倍半萜内酯。Britannin 通过激活由 ROS 调节的 AMPK 来诱导肝癌细胞凋亡和自噬。Britannin 具有抗增殖和抗炎活性。
  3. GC35554 Brevilin A A sesquiterpene lactone with anticancer activity
  4. GC35509 BGT226 BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.
  5. GC35497 Berberine chloride hydrate As isoquinoline alkaloid with diverse biological activities
  6. GC35462 Bafetinib A Bcr-Abl inhibitor
  7. GC35445 Azathramycin Azathramycin (Azaerythromycin A, Azaerythromycin) is a macrolide antibiotic containing cladinose.
  8. GC35434 Autogramin-2 Autogramin-2 有效抑制由饥饿诱导的自噬 (autophagy)，IC50 为 0.27 μM。Autogramin-2 也抑制 Rapamycin (通过抑制 mTORC1) 诱导的自噬 (autophagy)，IC50 为 0.14 μM。
  9. GC35433 Autogramin-1 Autogramin-1 有效抑制由饥饿诱导的自噬 (autophagy)，IC50 为 0.17 μM。Autogramin-1 也抑制 Rapamycin (通过抑制 mTORC1) 诱导的自噬 (autophagy)，IC50 为 0.44 μM。
  10. GC35432 Autocamtide-2-related inhibitory peptide (TFA) A CaMKII inhibitor
  11. GC35419 Atorvastatin 阿托伐他汀（Atorvastatin）是一种口服活性HMG-CoA还原酶抑制剂，可以有效降低血脂
  12. GC35322 Amiodarone Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
  13. GC35268 AGN 205728 AGN 205728是选择性RARγ拮抗剂，Ki/IC95分别为3 nM/ 0.6 nM，对RARα和RARβ无抑制性。
  14. GC35267 AGN 205327 AGN 205327是RAR激动剂，对RARα/β/γ的EC50分别为3766/734/32 nM，对RXR无抑制性。
  15. GC35266 AGN 196996 AGN 196996是高活性RARα选择性抑制剂，Ki为2 nM，对RARβ和RARγ的亲和性极低（Ki分别为1087 nM和8523 nM）。
  16. GC35265 AGN 195183 AGN 195183是RARα选择性激动剂，Kd为3 nM，相对于AGN 193836有更好的结合选择性，对RARβ/γ无活性。
  17. GC35262 Afzelin A polyphenolic glycoside flavone with diverse biological activities
  18. GC35242 Actein Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖，诱导自噬和凋亡。Actein 在体内几乎没有毒性。
  19. GC35238 Aclacinomycin A hydrochloride Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子，是第一个发现对 20S 蛋白酶体 (20S proteasome) 的CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效治疗血癌和实体肿瘤的蒽环类化疗药物。
  20. GC35228 Aceglutamide An acetylated form of L-glutamine
  21. GC35211 A-317491 sodium salt hydrate A P2X3 and P2X2/3 receptor antagonist
  22. GC35132 4-Hydroxylonchocarpin 4-Hydroxylonchocarpin 是一种查尔酮化合物，来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK，JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性，包括抗菌，抗癌，抗逆转录酶，抗结核，抗疟，抗炎和抗氧化活性。
  23. GC35112 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.
  24. GC35068 1-Monomyristin A monoacylglycerol
  25. GC34960 (+)-Talarozole (+)-Talarozole 是视黄酸代谢的有效抑制剂，来自专利 WO 1997049704 A1。
  26. GC45187 Zoledronic Acid (hydrate) A bisphosphonate that inhibits bone resorption
  27. GC45185 Z-LLL-AMC A fluorogenic substrate for proteasomal chymotrypsin-like activity
  28. GC45184 Z-LLE-AMC A fluorogenic substrate for proteasomal caspase-like activity
  29. GC45099 U-0126

    A MEK inhibitor and AMPK activator
  30. GC45064 Tomatidine (hydrochloride) A steroidal alkaloid with diverse biological activities
  31. GC44963 Suc-Leu-Tyr-AMC A calpain and papain substrate
  32. GC44856 Rutin (hydrate) A flavonoid glycoside with diverse biological activities
  33. GC44839 Ridaifen-B An analog of tamoxifen
  34. GC44797 Quinacrine analog 34 An autophagy inhibitor
  35. GC44680 Pregnenolone sulfate (sodium salt) A metabolite of pregnenolone
  36. GC44464 NSC 109555 An inhibitor of Chk2
  37. GC44400 Niclosamide (ethanolamine salt)

    An anthelmintic mitochondrial uncoupler
  38. GC44346 N-Desethylamiodarone (hydrochloride) A CYP3A4 metabolite of amiodarone
  39. GC44291 NAB 2 An inhibitor of α-synuclein-induced toxicity
  40. GC44290 NAADP (sodium salt)

    A secondary messenger that induces calcium mobilization
  41. GC44059 LG 100268 An RXR agonist
  42. GC43999 Ketanserin (tartrate) A potent 5-HT2 receptor antagonist
  43. GC43922 Isovaleryl-L-carnitine (chloride) An acylcarnitine
  44. GC43599 Emetine (hydrochloride) An alkaloid with diverse biological activities
  45. GC43359 Cytochalasin E Inhibitor of actin polymerization
  46. GC43354 Cysmethynil An inhibitor of protein prenylation
  47. GC43265 Chromomycin A2 An antibacterial and anticancer aureolic acid
  48. GC43189 CAY10681 A dual modulator of p53-MDM2 interaction and NF-κB signaling
  49. GC43105 C8 Ceramide (d18:1.8:0) A cell-permeable ceramide analog
  50. GC43048 C18 dihydro Ceramide (d18:0/18:0) A bioactive sphingolipid
  51. GC42958 Boc-LRR-AMC A fluorogenic substrate for trypsin-like activity of the 26S proteasome or 20S proteolytic core

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