Endogenous Metabolite(内源性代谢物)

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Products for Endogenous Metabolite

Cat.No. 产品名称 Information
GC19403 Protoporphyrin IX
原卟啉IX
卟啉代谢中的原卟啉 IX 是由原卟啉原氧化酶产生的。
GC19353 TFAP
N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide
A selective COX-1 inhibitor
GC18663 Leukotriene C4
白三烯C4
The parent cysteinyl leukotriene produced by LTC₄ synthase catalyzed conjugation of glutathione to LTA₄
GC18646 Myristelaidic Acid
十四碳烯酸(反-9),trans-9-Tetradecenoic acid

A monounsaturated ω-5 fatty acid
GC18628 3-Methylcrotonyl Glycine
N-(3-甲基-1-氧代-2-丁烯基)氨基乙酸
A metabolite with diverse biological activities
GC18583 D-α-Hydroxyglutaric Acid
R-2-羟基戊二酸,(R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid
D-α-Hydroxyglutaric Acid是α-酮戊二酸（α-KG）的弱竞争性拮抗剂（K_i = 10.87mM）。
GC18567 β-hydroxy Pyruvic Acid
[癸烷酸与2-乙基-2-(羟甲基)-1,3-丙二醇辛酯]的酯化物,3-hydroxy-2-Oxopropanoic acid
A metabolite in the process of photorespiration
GC18544 8-dehydro Cholesterol An isomer of 7-DHC
GC18515 8-iso Prostaglandin F2α
8-异前列腺素F2α
An isoprostane that inhibits platelet aggregation
GC18398 Sitostanol
豆甾烷醇
A saturated plant sterol
GC18389 9-cis Retinal
9-顺式视黄醛

A natural retinoid
GC18289 Lathosterol
Δ7-Cholestenol, γ-Cholestenol
An intermediate in the biosynthesis of cholesterol
GC18232 Prostaglandin D2
前列腺素D2,PGD2

A major prostaglandin produced by mast cells
GC18224 Cholesterol α-Linolenate
胆甾烯基亚麻酸酯,Cholesteryl Linolenate
A cholesterol ester
GC16403 2-Arachidonoyl Glycerol
2-花生酰基甘油乙腈溶液,2-AG

Endogenous CB₁ and CB₂ receptor agonist
GC11941 Flavin adenine dinucleotide disodium
黄素腺嘌呤二核苷酸二钠盐; FAD disodium salt; FAD-Na2; FAD
A flavin dinucleotide
GC11357 Dihomo-γ-Linolenic Acid
顺式-8，11，14-二十烷三烯酸甲酯,all-cis-8,11,14-Eicosatrienoic acid
ω-6 fatty acid intermediate
GC13377 3-hydroxy Anthranilic Acid
3-羟基-2-氨基苯甲酸,3-HAA,NSC 522891
A tryptophan metabolite
GC15365 N-Acetylserotonin
N-乙酰-5-羟色胺,N-Acetyl-5-hydroxytryptamine,NAS
N-Acetylserotonin是褪黑素生物合成中的一个化学中间体，以昼夜节律的方式激活酪氨酸激酶受体B（TrkB）。
GC14953 Spermine
精胺,Gerontine,Musculamine,Neuridine,NSC 268508,1,5,10,14-Tetraazatetradecane
A natural polyamine
GC16200 L-Biopterin
L-生物喋呤,L-erythro-Biopterin,NSC 339699
An intermediate for tetrahydro-L-biopterin
GC10312 Trehalose
D-海藻糖; D-Trehalose; α,α-Trehalose
A natural non-reducing disaccharide
GC13216 trans-trans Muconic acid
反式,反式-1,3-丁二烯-1,4-二羧酸
trans-trans Muconic acid 是一种苯的尿代谢物，已被用作人体接触苯的生物标志物。
GC10577 trans-Aconitic acid
反式乌头酸
反式乌头酸存在于正常人的尿液中，并且有人建议在雷氏综合征和有机酸尿症中存在大量的乌头酸。
GC15457 Pyridoxine
吡哆醇; Pyridoxol
A 4-methanol form of vitamin B₆
GC15994 Pyridoxal hydrochloride
吡哆醛盐酸盐
A transport form of vitamin B₆
GC10084 Pyridoxal 5 phosphate
磷酸吡哆醛; Pyridoxal 5′-phosphate; Pyridoxyl phosphate
An enzyme cofactor
GC13749 O-Phosphorylethanolamine
乙醇胺磷酸酯,Monoaminoethyl phosphate; NSC 254167; O-Phosphoethanolamine
A phospholipid metabolite
GC11828 N-carbamoyl-DL-aspartic acid
脲基琥珀酸; Ureidosuccinic Acid
An intermediate in pyrimidine biosynthesis
GC15129 N-Acetylneuraminic acid
唾液酸; NANA; Lactaminic acid
An abundant sialic acid
GC17521 N-acetyl D-galactosamine
N-乙酰-D-半乳糖胺
An amino sugar derivative of galactose
GC10292 myo-Inositol
肌醇; myo-Inositol; meso-Inositol
肌醇是一种化合物，许多食物中都含有相关的脂质，特别是水果，尤其是哈密瓜和橙子。
GC10631 Melibiose
蜜二糖
蜜二糖是一种二糖，由一个半乳糖和一个葡萄糖部分组成的 α (1-6) 糖苷键。
GC17814 L-Sorbose
L-山梨糖
A monosaccharide
GC10353 L-homocystine
L-高胱氨酸
L-同型半胱氨酸是 L-同型半胱氨酸的氧化成员。
GC12518 L-Dihydroorotic acid
L-氢化乳清酸
L-二氢乳清酸可以通过二氢乳清酶可逆地水解产生无环L-脲基琥珀酸。
GC10730 L-Arabitol
L-(-)-阿拉伯糖醇
L-Arabitol 是红薯、鹿莓、蛾豆等食品消耗的潜在生物标志物，还与阿尔茨海默病和 5-磷酸核糖异构酶缺乏症有关。
GC13084 Ketoisovaleric acid
3-甲基-2-氧丁酸
Ketoisovaleric acid（KIV）是亮氨酸和缬氨酸合成的前体。
GC12809 Itaconic acid
衣康酸
Itaconic acid是一种不饱和二羧酸，可由原核生物和真菌合成，也可在哺乳动物巨噬细胞感染过程中由乌头酸脱羧酶1（ACOD1，也称为IRG1）产生和分泌。
GC16949 Guanine
鸟嘌呤

A purine base
GC15388 Glyoxylic acid
乙醛酸,NSC 27785; Formylformic acid; Oxalaldehydic acid

乙醛酸 (NSC 27785) 是一种既是醛又是羧酸的有机化合物。
GC17170 gamma-Glu-Cys
G-谷氨酸-半胱氨酸,γ-Glutamylcysteine
γ-Glu-Cys (γ-Glutamylcysteine) 是一种含有半胱氨酸和谷氨酸的二肽，是谷胱甘肽 (GSH) 的前体。
GC14331 Folinic acid
亚叶酸; leucovorin
亚叶酸 (Leucovorin) 是一种生物叶酸，通常与甲氨蝶呤 (MTX) 一起作为救援剂给药，以降低 MTX 诱导的毒性。
GC13392 Flavin adenine dinucleotide
黄素腺嘌呤二核苷酸; FAD
黄素腺嘌呤二核苷酸 (FAD) 是一种氧化还原辅助因子，更具体地说是蛋白质的辅基，参与代谢中的几个重要酶促反应。
GC13531 Deoxyadenosine 5-triphosphate
2'-脱氧腺苷5'-三磷酸酯,dATP
Deoxyadenosine 5-triphosphate是一种由一个腺嘌呤碱基、一个脱氧核糖和三个磷酸基团组成的脱氧核苷酸三磷酸。
GC16449 Cellobiose
D-纤维二糖
A disaccharide
GC16971 β-Nicotinamide mononucleotide
烟酰胺单核苷酸; β-NM; NMN
β-烟酰胺单核苷酸是烟酰胺磷酸核糖转移酶（NAMPT）反应的产物，也是关键的NAD+中间体。
GC17558 Adenosine 5'-triphosphate disodium salt hydrate
腺苷5'-三磷酸二钠盐水合物,Adenosine 5'-triphosphate disodium salt hydrate

Adenosine 5'-triphosphate disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) 是体内能量储存和代谢的核心成分，提供代谢能量以驱动代谢泵，并作为细胞中的辅酶。
GC13172 Adenosine 5-monophosphate
腺苷酸; AMP
5-单磷酸腺苷是调节能量稳态和信号转导的关键细胞代谢物。
GC10880 cAMP (Standard)
Synonyms: 环磷腺苷; Cyclic adenosine monophosphate; Adenosine cyclic 3', 5'-monophosphate; Cyclic AMP; Adenosine 3-5-cyclic monophosphate
A second messenger