Ubiquitination/ Proteasome(泛素化/蛋白酶体)

Cat.No. 产品名称 Information

GC10064 Flurizan

R-氟比洛芬; (R)-Flurbiprofen; MPC7869

A COX-inactive enantiomer of flurbiprofen

GC16912 PD 150606 An inhibitor of calpains

GC11640 MDL 28170

Calpain Inhibitor III

A cell permeable, selective calpain inhibitor

GC17255 Gliotoxin

胶霉毒素,Aspergillin

Gliotoxin是一种由病原性曲霉菌等真菌产生的免疫抑制性霉菌毒素，是一种特异性的20S蛋白酶体糜蛋白酶活性抑制剂，IC₅₀为10μM。

GC10342 Calpeptin

A calpain inhibitor

GC15632 YM-155 hydrochloride

YM155 hydrochloride;YM 155 hydrochloride

A survivin inhibitor

GC11007 VO-Ohpic trihydrate

VO-OHPIC三水合物,VO-Ohpic;VO Ohpic

A specific inhibitor of PTEN

GC14806 Vinorelbine ditartrate

酒石酸长春瑞滨; KW-2307; Nor-5'-anhydrovinblastine ditartrate

An inhibitor of microtubule polymerization

GC12286 Vinblastine sulfate

硫酸长春碱; Vincaleukoblastine sulfate salt

Vinblastine sulfate是一种细胞毒性生物碱。

GC11876 Vandetanib hydrochloride

Zactima hydrochloride; ZD6474 hydrochloride;ZD-6474 hydrochloride; ZD 6474 hydrochloride

A multi-kinase inhibitor

GC15272 Troglitazone

曲格列酮; CS-045

Selective PPARγ agonist

GC13984 Tamibarotene

他米巴罗汀; Am 80

A selective RARα agonist

GC17063 Talarozole

他拉罗唑; R115866

Talarozole (R115866) 是一种口服全身性全反式维甲酸代谢阻断剂 (RAMBA)，可增加内源性全反式维甲酸 (RA) 的细胞内水平。

GC16148 TAK-242

瑞沙托维; TAK-242; CLI-095

TAK 242 是一种 Toll 样受体 4 (TLR4) 信号转导抑制剂。

GC13578 Skepinone-L

Skepinone L

An inhibitor of p38 MAPK

GC17698 SJB2-043 An inhibitor of the USP1-UAF1 complex and SARS-CoV-2 PL^pro

GC11455 Silvestrol

(1R,2R,3S,3AR,8BS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-二羟基乙基]-3-甲氧基-1,4-二氧己环-2-基]氧基]-2,3,3A,8B-四氢-1,8B-二羟基-8-甲氧基-3A-(4-甲氧基苯基)-3-苯基-1H-环戊烯并[B]苯并呋喃-2-羧酸甲酯,(-)-Silvestrol

Silvestrol 是一种真核翻译起始因子 4A (eIF4A) 抑制剂，从 Agave americana Linn 中分离出来。Silvestrol 诱导自噬和半胱天冬酶介导的细胞凋亡。

GC11369 Sildenafil

西地那非; UK-92480

西地那非，作为一种磷酸二酯酶 5 (PDE-5) 抑制剂，用于治疗肺动脉高压 (PAH)。

GC10054 SB 239063

反式-1-(4-羟基环己基)-4-(4-氟苯基)-5-(2-甲氧基嘧啶-4-基)咪唑,SB-239063;SB239063

A selective p38 MAPK inhibitor

GC15785 Saquinavir mesylate

沙奎那韦甲磺酸盐; Ro 31-8959/003

An HIV protease inhibitor

GC10528 Salirasib

法尼基硫代水杨酸; S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS

A Ras inhibitor with anti-cancer and anti-atherogenic activity

GC18107 Salinomycin sodium salt

盐霉素钠; Salinomycin sodium; Sodium salinomycin

A selective cancer stem cell inhibitor

GC14882 Salinomycin

盐霉素; Procoxacin

A selective cancer stem cell inhibitor

GC16124 Ruxolitinib phosphate

鲁索利替尼磷酸盐,INCB018424 phosphate;INCB 018424 phosphate;INCB-018424 phosphate;Ruxolitinib

A potent and selective JAK1/JAK2 inhibitor

GC14651 Reversine

逆转素

Reversine是一种靶向Aurora A激酶、Aurora B激酶和MPS1（Monopolar Spindle 1）激酶的非特异性、具有口服活性的小分子抑制剂。Reversine常用于细胞分化和多种癌症的研究。

GC14534 Regorafenib monohydrate

瑞格非尼一水合物,BAY 73-4506 monohydrate

A multi-kinase inhibitor

GC14606 Regorafenib hydrochloride

瑞戈非尼盐酸盐; BAY 73-4506 hydrochloride

A multi-kinase inhibitor

GC13625 Pramipexole dihydrochloride

盐酸普拉克索

A dopamine D_2S, D_2L, D₃, and D₄ receptor agonist

GC16379 PI-103 Hydrochloride

PI 103 hydrochloride;PI103 hydrochloride

A potent, cell-permeable PI3K inhibitor

GC17694 Pemetrexed disodium hemipenta hydrate

培美曲塞二钠水合物; LY231514 disodium hemipenta hydrate

Pemetrexed disodium hemipenta hydrate 是一种新型抗叶酸剂，LY231514 的五谷氨酸的 Ki 值分别为 1.3、7.2 和 65 nM，用于抑制胸苷酸合酶 (TS)、二氢叶酸还原酶 (DHFR) 和甘氨酰胺核糖核苷酸甲酰转移酶 (GARFT)。

GC10470 Nutlin-3a chiral

Nutlin-3a;Nutlin 3a

Nutlin-3a 手性是 Nutlin-3 的活性异构体，是鼠类双微体 2 (MDM2) 拮抗剂，IC50 值为 0.09μM。

GC18089 Nordihydroguaiaretic acid

去甲二氢愈创木酸; NDGA

A non-selective LO inhibitor

GC14237 Nilotinib monohydrochloride monohydrate

尼洛替尼盐酸盐一水合物; AMN107 monohydrochloride monohydrate

A Bcr-Abl inhibitor

GC17136 MRT67307

N-[3-[[5-环丙基-2-[[3-(4-吗啉基甲基)苯基]氨基]-4-嘧啶基]氨基]丙基]环丁烷甲酰胺,MRT 67307;MRT-67307

A kinase inhibitor

GC15854 Mefloquine hydrochloride

盐酸甲氟喹,Mefloquin hydrochloride

An antimalarial compound

GC17874 Matrine

苦参碱; Matridin-15-one; Vegard; α-Matrine

苦参碱（Matrine）是一种存在于槐属植物中的生物碱，可作为 kappa 阿片受体和µ-受体激动剂。

GC15094 LY2183240

5-([1,1'-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺,LY 2183240; LY-2183240

A potent, competitive inhibitor of anandamide uptake

GC10629 KN-93

N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羟乙基)-4-甲氧苯磺酰胺磷酸酯盐,KN 93;KN93

Selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II

GC16981 KN-92 phosphate

KN-92磷酸盐,KN 92 phosphate;KN92 phosphate

KN-92 phosphate 是 KN-93 的无活性衍生物，没有 CaM 激酶抑制活性。 KN-92 磷酸盐旨在用作旨在阐明 KN-93 拮抗剂活性的研究中的对照化合物。 KN-93 是一种细胞渗透性、可逆性和竞争性 CaMKII 抑制剂。

GC15988 KN-92 hydrochloride

KN-92盐酸盐,KN 92 hydrochloride;KN92 hydrochloride

An inactive control compound for a CaMKII inhibitor

GC14132 KN-92

KN 92;KN92

An inactive control compound for a CaMKII inhibitor

GC15684 KB-R7943 mesylate

KB-R7943甲磺酰酸盐,KB-R7943; KB-R 7943

An inhibitor of the reverse Na⁺/Ca²⁺ exchanger

GC15730 Kaempferide

山奈素; Kaempferol 4'-O-methyl ether

A flavonoid with diverse biological activities

GC13316 Ivacaftor hydrate

VX-770 hydrate;VX 770 hydrate;VX770 hydrate;Kalydeco hydrate

A CFTR potentiator

GC12489 Ivacaftor benzenesulfonate

VX-770 benzenesulfonate;VX 770 benzenesulfonate;VX770 benzenesulfonate;Kalydeco benzenesulfonate

A CFTR potentiator

GC13795 Isobavachalcone

补骨脂乙素; Corylifolinin; Isobacachalcone

A chalcone and flavonoid with diverse biological activities

GC10939 Hoechst 33342 trihydrochloride

2'-(4-乙氧基苯基)-5-(4-甲基-1-哌嗪基)-2,5'-联-1H-苯并咪唑三盐酸盐,bisBenzimide H 33342;HOE 33342;Hoechst-33342;Hoechst33342

Hoechst 33342 trihydrochloride是一种DNA荧光染料，最大激发/发射光分别为350/460nm。

GC17534 GSK343

GSK-343;GSK 343

A selective, cell-permeable EZH2 inhibitor

GC17450 GSK2606414

GSK 2606414;GSK-2606414

GSK2606414是一种具有口服活性的选择性蛋白激酶R样内质网激酶（PERK）抑制剂，IC₅₀值为0.4nM。

GC16154 GDC-0941 dimethanesulfonate

GDC-0941 (2 MeSO3H salt);GDC0941 dimethanesulfonate;GDC-0941;GDC0941;GDC 0941

A pan inhibitor of class I PI3K isoforms