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Home >> Signaling Pathways >> Tyrosine Kinase >> VEGFR

VEGFR(血管内皮生长因子受体)

VEGFR are receptors for vascular endothelial growth factor and belong to receptor tyrosine kinases.

Products for  VEGFR

  1. Cat.No. 产品名称 Information
  2. GC37047 Pz-1 Pz-1是有效地 RET 和 VEGFR2 受体酪氨酸激酶抑制剂，Pz-1抑制这两个野生型激酶的 IC50 值小于 1 nM。
  3. GC36745 Nintedanib esylate

    Nintedanib esylate, as a kinase inhibitor, used for the treatment of non-small cell lung cancer suffered from first-pass metabolism which resulted in low oral bioavailability .
  4. GC36744 Ningetinib Tosylate A multi-kinase inhibitor
  5. GC36438 Lenvatinib mesylate An inhibitor of VEGFR2 and VEGFR3
  6. GC36203 GW806742X GW806742X 是一种混合谱系激酶结构域样蛋白 (MLKL) 抑制剂，结合 MLKL 假激酶域的 Kd 值为 9.3 μM，并具有抗坏死活性。GW806742X 也具有抗 VEGFR2 的活性。
  7. GC35516 BIBF 1202 An active metabolite of BIBF 1120
  8. GC35263 AG-13958 AG-13958 (AG-013958), a VEGFR tyrosine kinase inhibitor, is in clinical development with ST administration for treatment of choroidal neovascularization associated with age–related macular degeneration (AMD).
  9. GC44958 SU 5205 An inhibitor of VEGFR2
  10. GC43885 Hypothemycin A resorcylic acid lactone polyketide with diverse biological activities
  11. GC40755 SU 5214 A 3-heteroaryl-2-indoline
  12. GC19534 Ramucirumab Ramucirumab 是一种人 VEGFR-2 拮抗剂，用于治疗实体瘤。 Ramucirumab 是一种重组人免疫球蛋白 G1 单克隆抗体，可与 VEGFR-2 的细胞外结合结构域结合并阻止 VEGFR 配体:VEGF-A、VEGF-C 和 VEGF-D 的结合。 Ramucirumab 也是一种血管生成抑制剂。
  13. GC34216 Bevacizumab (Anti-Human VEGF, Humanized Antibody) 贝伐单抗Bevacizumab是一种抗VEGF的人源化单克隆抗体。.
  14. GC34159 Ilorasertib (ABT-348) A multi-kinase inhibitor
  15. GC34126 NVP-ACC789 (ACC-789) An inhibitor of VEGFRs
  16. GC34026 Tyrosine kinase-IN-1 Tyrosinekinase-IN-1是多靶点的酪氨酸激酶抑制剂，抑制KDR，Flt-1，FGFR1和PDGFRα的IC50值分别为4，20，4，2nM。
  17. GC33840 SU1498 (AG 1498) A selective inhibitor of VEGFR2/FLK1
  18. GC33352 CP-547632 A potent inhibitor of VEGFR2 and bFGF
  19. GC33273 TAS-115 mesylate (TAS-115 methanesulfonate) A multi-kinase inhibitor
  20. GC33271 R916562 R916562是有效的和有选择性的Axl/VEGF-R2双重抑制剂,IC50值分别为136和24nM。
  21. GC33173 TAS-115 A multi-kinase inhibitor
  22. GC33171 ZD-4190 ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively.
  23. GC33087 2,4-Pyrimidinediamine with linker A multi-kinase inhibitor
  24. GC33004 Cediranib maleate (AZD-2171 maleate) An inhibitor of VEGF receptor tyrosine kinases
  25. GC32979 Chloropyramine hydrochloride Chloropyramine hydrochloride (Halopyramine) is a histamine receptor H1 antagonist and has anti-cholinergic, antispasmodic, and antiallergic effects.
  26. GC32963 hVEGF-IN-1 hVEGF-IN-1, a quinazoline derivative, specifically binds to the G-rich sequence in the internal ribosome entry site A (IRES-A) with a Kd of 0.928 μM, therefore destabilizes the G-quadruplex structure, , also hinders tumor cells migration and represses tumor growth by decreasing VEGF-A protein expression.
  27. GC32805 Sulfatinib (HMPL-012) A multi-kinase inhibitor
  28. GC32625 KDR-in-4 KDR-in-4 (KDR-in-4) 是一种有效的激酶插入结构域受体 (KDR/VEGFR2) 抑制剂，IC50 为 7 nM。
  29. GC32502 Oglufanide (H-Glu-Trp-OH) Oglufanide (H-Glu-Trp-OH) (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂。
  30. GC32469 SU5408 (VEGFR2 Kinase Inhibitor I) A potent, cell-permeable inhibitor of VEGFR2
  31. GC31816 ZK-261991 ZK-261991是一种可口服的VEGFR酪氨酸酶抑制剂，抑制VEGFR-2活性的IC50值为5nM。
  32. GC31752 Tesevatinib (XL-647) A multi-kinase inhibitor
  33. GC30242 Acrizanib Acrizanib是VEGFR-2的抑制剂，其IC50值为17.4nM。
  34. GC19332 Sitravatinib A multi-kinase inhibitor
  35. GC19108 SCR-1481B1 A pyridone
  36. GC18211 Ningetinib A multi-kinase inhibitor
  37. GC18168 JI-101 An inhibitor of VEGFR2, PDGFRβ, and EphB4
  38. GC16062 VEGFR Tyrosine Kinase Inhibitor II An inhibitor of KDR, FLT1, and c-Kit
  39. GC10938 AAL-993 Inhibitor of VEGFR1, 2, and 3
  40. GC15280 Tivozanib (hydrate) A VEGFR inhibitor
  41. GC16483 MAZ51 An antagonist of VEGFR3 (FLT4)
  42. GC11726 BAW2881 (NVP-BAW2881) A VEGFR inhibitor
  43. GC15340 BFH772 An inhibitor of VEGFR2
  44. GC10165 Dovitinib (TKI258) Lactate A multi-kinase inhibitor
  45. GC10355 Fruquintinib(HMPL-013) An inhibitor of VEGF1, -2, and -3
  46. GC17959 AZD2932 A multi-kinase inhibitor
  47. GC16604 Altiratinib A multiple kinase inhibitor
  48. GC15801 ACTB-1003 A multi-kinase inhibitor
  49. GC17098 DMH4 A VEGFR2 inhibitor
  50. GC10195 Z-Guggulsterone A farnesoid X receptor antagonist
  51. GC13344 (Z)-FeCP-oxindole (Z)-FeCP-oxindole 是一种选择性人血管内皮生长因子受体 2 (VEGFR2) 抑制剂，IC50 值为 200 nM。 (Z)-FeCP-oxindole 在 10 μM 时可显着抑制 VEGFR1 和 PDGFRa 或 b。 (Z)-FeCP-oxindole 具有一定的抗癌活性，作用于 B16 鼠黑色素瘤系，IC50 小于 1 μM。

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