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Home >> Signaling Pathways >> Proteases >> Endogenous Metabolite

Endogenous Metabolite(内源性代谢物)

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Products for  Endogenous Metabolite

  1. Cat.No. 产品名称 Information
  2. GC45339 3-Oxocholic Acid

    3-酮基-7ALPHA,12ALPHA-二羟基-5ALPHA-胆烷酸,3-Dehydrocholic Acid

     A secondary bile acid
  3. GC38010 γ-Aminobutyric acid

    γ-氨基丁酸

     γ-氨基丁酸（γ-Aminobutyric acid，GABA）是成人大脑中的主要抑制性神经递质。
  4. GC37942 Xanthosine

    黄嘌呤核苷

     Xanthosine (Xanthine riboside) is an intermediate in purine metabolism, formed from IMP, and forming GMP.
  5. GC37866 Uridine diphosphate glucose

    UDP-葡萄糖

     尿苷二磷酸葡萄糖（尿嘧啶二磷酸葡萄糖，UDPG）是一种核苷酸糖。
  6. GC37864 Uridine 5'-monophosphate

    尿苷5-单磷酸; 5'-?Uridylic acid

     A ribonucleotide
  7. GC37826 Tricaprilin

    三辛酸甘油酯,Trioctanoin; Glyceryl trioctanoate

     A triacylglycerol
  8. GC37790 Tiglic acid

    巴豆酸

     Tiglic acid (Cevadic acid, Sabadillic acid, Tiglinic acid) is a monocarboxylic unsaturated organic acid found in croton oil and in several other natural products. It is used in making perfumes and flavoring agents.
  9. GC37754 Teglicar

    替格列卡

     Teglicar 是选择性和可逆性的肉毒碱棕榈酰转移酶 1 (L-CPT1) 肝异构体抑制剂，可减少酮生成和葡萄糖生成，降低糖异生，改善葡萄糖稳态。Teglicar 具有潜在的抗高血糖特性。
  10. GC37711 T2 toxin Triol

    T2三醇

     T2 toxin Triol 是 T-2 toxin 代谢产生的一种真菌毒素 (孢菌毒素)，其毒性低于 T-2 toxin 。在肉鸡中评估 T2 toxin Triol 的主要代谢物指数，它的半衰期 (t1/2λz)，峰值血浆浓度 (Cmax) 以及Tmax 值分别为 9.6 mins，563 ng/ml，2.5 mins。
  11. GC37700 Succinyl phosphonate trisodium salt

    琥珀酰膦酸盐

     Succinyl phosphonate trisodium salt (SP) 琥珀酰膦酸三钠盐是 α-酮戊二酸脱氢酶 (KGDHC ) 抑制剂，可有效抑制肌肉，细菌，脑和人成纤维细胞中的 KGDHC。Succinyl phosphonate trisodium salt (SP) 抑制 2-氧代戊二酸脱氢酶 (OGDH)，以细胞特异性代谢依赖性方式损害癌细胞的活力。Succinyl phosphonate trisodium salt (SP) 抑制谷氨酸诱导的谷氨酸刺激的海马神经元中的 ROS 产生。
  12. GC37686 Stachydrine

    水苏碱

     A pyrrolidine betaine with anticancer and cardioprotective effects
  13. GC37652 Smilagenin

    Smilagenin (SMI) 是一种脂溶性小分子甾体皂苷元，来自知母 Rhizoma anemarrhenae 和天竺葵 Radix asparagi，广泛用于治疗慢性神经退行性疾病的中药。Smilagenin (SMI) 通过增加毒蕈碱受体亚型 1 (M1)-受体的的密度来改善老年大鼠的记忆。Smilagenin (SMI) 通过刺激脑源性神经营养因子的基因表达减弱 Aβ(25-35) 诱导的神经变性，可能代表 AD 的新型治疗策略。
  14. GC37558 Rosmarinic acid racemate

    迷迭香素

     Rosmarinic acid racemate是Rosmarinic acid的外消旋体。Rosmarinic acid抑制MAO-A, MAO-B 和COMT酶，IC50分别为50.1, 184.6 和26.7 μM。
  15. GC37532 Riboflavine phosphate

    2,6-蒽二酚,Riboflavine 5'-phosphate

     磷酸核黄素是核黄素（维生素 B2）的衍生物，是动物必需的营养素。
  16. GC37530 Riboflavin phosphate sodium

    核黄素磷酸钠; FMN-Na; Riboflavin 5'-phosphate sodium; Vitamin B2 Phosphate Sodium Salt

     Flavin mononucleotide (riboflavin-5'-phosphate, FMN) is a biomolecule produced from riboflavin (vitamin B2) by the enzyme riboflavin kinase and functions as prosthetic group of various oxidoreductases including NADH dehydrogenase as well as cofactor in biological blue-light photo receptors.
  17. GC37033 p-Synephrine

    (-)-辛弗林

     p-Synephrine 是一种常见的有机物，在尿液和血液中比较常见。
  18. GC36979 Propionylcarnitine

    丙酰肉碱

     Propionylcarnitine是L-肉碱与丙酰辅酶A（Propionyl-CoA）在肉碱酰基转移酶（Carnitine Acyltransferase）催化下生成的酯类代谢物。
  19. GC36963 Pregnenolone monosulfate

    3β-Hydroxy-5-pregnen-20-one monosulfate

     Pregnenolone monosulfate 是大麻素 CB1 受体的特异性抑制剂。
  20. GC36903 Phytic acid dodecasodium salt hydrate

    植酸十二钠盐; Inositol hexaphosphate dodecasodium hydrate

     Phytic acid (Inositol polyphosphate, Inositol hexakisphosphate) is the principal storage form of phosphorus in many plant tissues, especially bran and seeds. It can act as a cofactor in DNA repair by nonhomologous end-joining. Phytic acid inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.
  21. GC36899 Phosphocreatine disodium tetrahydrate

    磷酸肌酸二钠盐,Creatine phosphate disodium tetrahydrate; Creatinephosphoric acid disodium tetrahydrate

     磷酸肌酸二钠四水合物，主要存在于脊椎动物的骨骼肌中，是一种称为 α 氨基酸和衍生物的有机化合物，是测定肌酸激酶的底物，用于在骨骼肌收缩过程中再生 ATP。
  22. GC36898 Phosphocreatine

    磷酸肌酸,Creatine phosphate; Creatinephosphoric acid

     Phosphocreatine 主要存在于脊椎动物的骨骼肌中，属于α氨基酸及其衍生物的一种有机化合物，是测定肌酸激酶的底物，可用于骨骼肌收缩过程中ATP的再生。
  23. GC36791 Octanoic acid

    辛酸; Caprylic acid

     A medium-chain saturated fatty acid
  24. GC36737 Nicotinamide N-oxide

    烟酰胺-N-氧化物

     A metabolite of nicotinamide
  25. GC36678 N4-Acetylcytidine triphosphate sodium

    ac4CTP sodium

     N4-Acetylcytidine triphosphate sodium 是一种内源性核苷代谢物，源于 tRNA 的降解，可通过诱导 HMGB1 的表达，启动和激活 NLRP3 炎症。
  26. GC36590 Methyl 2-furoate

    2-糠酸甲酯,Methyl furan-2-carboxylate

     Methyl furan-2-carboxylate (Methyl pyromucate, Methyl 2-furoate) is found in cocoa and cocoa products. It is used in food flavouring and preparation of sesquiterpene lactone.
  27. GC36537 Maltose

    麦芽糖

     A disaccharide
  28. GC36536 Maltol

    麦芽酚

     Maltol是一种天然存在的有机化合物，是一种增香剂和调味剂。
  29. GC36535 Maltohexaose

    麦芽六糖,Amylohexaose

     Maltohexaose (Amylohexaose) is a polysaccharide with 6 units of glucose and can be classified as a maltodextrin.
  30. GC36532 Maleic Acid

    马来酸

     Maleic acid inhibits glutamate decarboxylase (GAD) activity, thus enhances acid sensitivity of Listeria monocytogenes. Maleic acid affects the extracellular GABA levels.
  31. GC36470 L-Lysine

    L-赖氨酸

    Lysine is an α-amino acid that is used in the biosynthesis of proteins and is required for growth and tissue repair.
  32. GC36469 L-Lactic acid

    L-乳酸; (S)-2-Hydroxypropanoic acid

     L-Lactic acid is a natural product that is used as a food additive.
  33. GC36465 Liothyronine An thyroid hormone which binds to TRβ1, and activates its activity
  34. GC36443 Levomefolic acid

    5-甲基四氢叶酸; 5-MTHF

     Levomefolic acid (5-MTHF, LMSR, Metafolin, Nutrifolin) is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.
  35. GC36431 L-Cysteine hydrochloride

    L-半胱氨酸盐酸盐

     A conditionally essential amino acid
  36. GC36419 Lactose

    乳糖,α-D-Lactose

     Lactose is a disaccharide naturally found in milk and dairy.
  37. GC36416 L-5-Hydroxytryptophan

    5-羟基色氨酸; L-5-HTP; Oxitriptan

     An intermediate in serotonin biosynthesis
  38. GC36412 L-Leucyl-L-alanine

    L-亮氨酸-L-丙氨酸

     L-Leucyl-L-alanine Hydrate (H-Leu-Ala-OH) is a dipeptide composed of L-leucine and L-alanine joined by a peptide linkage. It is a metabolite.
  39. GC36159 Glycerol 3-phosphate Glycerol 3-phosphate是由细胞溶质甘油3-磷酸脱氢酶途径产生的，胞质甘油3-磷酸脱氢酶（GPDH）消耗NADH从磷酸二羟基丙酮（DHAP）产生Glycerol 3-phosphate，生成的Glycerol 3-phosphate可穿过可渗透的线粒体外膜。Glycerol 3-phosphate为游离形式化合物不稳定，推荐具有相同生物学活性的稳定盐形式sn-Glycerol 3-phosphate lithium（GC61482）。
  40. GC36158 Glycerol

    甘油; Glycerin

     Glycerol (Glycerin) is a clear, colourless and viscous liquid that can be used as emollient, solvent or sweetening agent. Glycerol changes the separation characteristics of polyacrylamide nucleoprotein gels.
  41. GC36151 Glucagon-Like Peptide (GLP) II, human

    [ALA19]-GLUCAGON-LIKE肽II(大鼠)

     Glucagon-Like Peptide (GLP) II, human 是由原胰高血糖素 C 端衍生的33 氨基酸肽，主要由肠道L细胞产生。Glucagon-Like Peptide (GLP) II 可刺激肠粘膜生长，减少肠细胞的凋亡。
  42. GC35877 DL-Homocystine

    DL-高胱氨酸

     An oxidized dimeric form of homocysteine
  43. GC35866 Dimethyl trisulfide

    二甲基三硫

     Dimethyl trisulfide (Methyl trisulfide, DMTS, 2,3,4-trithiapentane) is an organic chemical compound and the simplest organic trisulfide.
  44. GC35865 Dihydroxyacetone phosphate

    1-HYDROXY-3-(PHOSPHONOOXY)-2-PROPANONE半镁盐

     A glycerolipid precursor
  45. GC35863 Diethyl oxalpropionate

    草酰丙酸二乙酯

     Methyloxalacetic acid diethyl ester (Diethyl 2-methyl-3-oxosuccinate, Diethyl methyloxobutanedioate, Diethyl oxalpropionate) is a member of the class of compounds known as beta-keto acids and derivatives.
  46. GC35861 Dichlorisone acetate

    醋酸二氯松；醋酸双氯松

     Dichlorisone acetate是用作抗炎剂的合成糖皮质激素皮质类固醇。
  47. GC35852 D-Glucose 6-Phosphate~1 M in H2O(260 mg/ml)

    D-葡萄糖-6-磷酸

     D-Glucose 6-Phosphate是葡萄糖经过磷酸化(在第6号碳的羟基上)生成的葡萄糖。
  48. GC35819 D-chiro-Inositol

    D-手性肌醇

     D-chiro-Inositol 是一种肌醇差向异构体，存在于某些哺乳动物糖基磷脂酰肌醇蛋白锚和具有胰岛素样生物活性的肌醇磷脂聚糖中。D-chiro-Inositol 用于治疗多囊卵巢综合征 (PCOS) 和糖尿病。D-chiro-Inositol 可降低高血糖，改善胰岛素抵抗。
  49. GC35794 D-(-)-Lactic acid

    D-乳酸

     D-(-)-Lactic acid 是糖发酵 (氧化，新成代谢) 的一个中间产物。D-(-)-Lactic acid 在植物中是 ProDH (proline dehydrogenase 1)) 的竞争性抑制剂。
  50. GC35793 D-(+)-Phenyllactic acid

    D-3-苯乳酸,D-3-Phenyllactic acid

     D-3-Phenyllactic acid is a chiral building block that is used in preparation of statine.
  51. GC35752 CS-722 Free base CS-722 Free base 是一种合成的中枢作用肌肉松弛剂，具有肌肉松弛活性和对脊髓反射的抑制作用。CS-722 Free base 可能通过抑制钠和钙电流来抑制海马培养物中的自发抑制性突触后电流和兴奋性突触后电流。

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