Propionylcarnitine
(Synonyms: 丙酰肉碱) 目录号 : GC36979
Propionylcarnitine是L-肉碱与丙酰辅酶A(Propionyl-CoA)在肉碱酰基转移酶(Carnitine Acyltransferase)催化下生成的酯类代谢物。
Cas No.:17298-37-2
Sample solution is provided at 25 µL, 10mM.
Propionylcarnitine is an ester metabolite generated by L-carnitine and propionyl-CoA under the catalysis of carnitine acyltransferase[1]. Elevated levels of Propionylcarnitine in serum are an indirect biomarker of vitamin B12 deficiency, because B12 deficiency inhibits the conversion of propionyl-CoA to succinyl-CoA, leading to accumulation of Propionylcarnitine[2]. Propionylcarnitine can act as a superoxide scavenger, antioxidant, and DNA cleavage protector[3]. Propionylcarnitine can alleviate oxidative stress damage to red blood cells in β-thalassemia[4].
References:
[1] Roseiro L C, Santos C. Carnitines (including l-carnitine, acetyl-carnitine, and proprionyl-carnitine)[M]//Nonvitamin and nonmineral nutritional supplements. Academic Press, 2019: 45-52.
[2] Hannibal L, Lysne V, Bjørke-Monsen A L, et al. Biomarkers and algorithms for the diagnosis of vitamin B12 deficiency[J]. Frontiers in molecular biosciences, 2016, 3: 27.
[3] Vanella A, Russo A, Acquaviva R, et al. L-propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector[J]. Cell biology and toxicology, 2000, 16: 99-104.
[4] Malaguarnera M, Vacante M, Giordano M, et al. L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-α 2b plus ribavirin[J]. World journal of gastroenterology: WJG, 2011, 17(39): 4414.
Propionylcarnitine是L-肉碱与丙酰辅酶A(Propionyl-CoA)在肉碱酰基转移酶(Carnitine Acyltransferase)催化下生成的酯类代谢物[1]。血清中 Propionylcarnitine的升高是维生素B12缺乏的间接生物标志物,因为B12缺乏会抑制丙酰辅酶A向琥珀酰辅酶A的转化,导致丙酰肉碱蓄积[2]。Propionylcarnitine能够作为超氧化物清除剂、抗氧化剂和DNA切割保护剂[3]。Propionylcarnitine在β-地中海贫血中能够缓解红细胞的氧化应激损伤[4]。
Cas No. | 17298-37-2 | SDF | |
别名 | 丙酰肉碱 | ||
Canonical SMILES | CCC(OC(CC([O-])=O)C[N+](C)(C)C)=O | ||
分子式 | C10H19NO4 | 分子量 | 217.26 |
溶解度 | DMSO: 125 mg/mL (575.35 mM) | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
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1 mg | 5 mg | 10 mg |
1 mM | 4.6028 mL | 23.0139 mL | 46.0278 mL |
5 mM | 0.9206 mL | 4.6028 mL | 9.2056 mL |
10 mM | 0.4603 mL | 2.3014 mL | 4.6028 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
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% DMSO % % Tween 80 % saline | ||||||||||
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计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
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Quality Control & SDS
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- Purity: >99.50%
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