Glycerol
(Synonyms: 甘油; Glycerin) 目录号 : GC36158
Glycerol (Glycerin) is a clear, colourless and viscous liquid that can be used as emollient, solvent or sweetening agent. Glycerol changes the separation characteristics of polyacrylamide nucleoprotein gels.
Cas No.:56-81-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
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Animal experiment: |
Rats: Experimental acute renal failure was induced in male Wistar rats 230-300 g by an injection of glycerol dissolved in saline (50% v/v, 10 mL/kg) into the leg muscle after a 24-h period of water deprivation[3]. |
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References: [1]. Pennings S, et al. Effect of glycerol on the separation of nucleosomes and bent DNA in low ionic strengthpolyacrylamide gel electrophoresis. Nucleic Acids Res. 1992 Dec 25;20(24):6667-72. |
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Glycerol (Glycerin) is a clear, colourless and viscous liquid that can be used as emollient, solvent or sweetening agent. Glycerol changes the separation characteristics of polyacrylamide nucleoprotein gels.
[1] S Pennings, et al. Nucleic Acids Res. 1992 Dec 25;20(24):6667-72.
| Cas No. | 56-81-5 | SDF | |
| 别名 | 甘油; Glycerin | ||
| Canonical SMILES | OCC(O)CO | ||
| 分子式 | C3H8O3 | 分子量 | 92.09 |
| 溶解度 | DMSO: ≥ 300 mg/mL (3257.68 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 10.8589 mL | 54.2947 mL | 108.5894 mL |
| 5 mM | 2.1718 mL | 10.8589 mL | 21.7179 mL |
| 10 mM | 1.0859 mL | 5.4295 mL | 10.8589 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Preparation and Uses of Chlorinated Glycerol Derivatives
Molecules 2020 May 28;25(11):2511.PMID:32481583DOI:10.3390/molecules25112511.
Crude Glycerol (C3H8O3) is a major by-product of biodiesel production from vegetable oils and animal fats. The increased biodiesel production in the last two decades has forced Glycerol production up and prices down. However, crude Glycerol from biodiesel production is not of adequate purity for industrial uses, including food, cosmetics and pharmaceuticals. The purification process of crude Glycerol to reach the quality standards required by industry is expensive and dificult. Novel uses for crude Glycerol can reduce the price of biodiesel and make it an economical alternative to diesel. Moreover, novel uses may improve environmental impact, since crude Glycerol disposal is expensive and dificult. Glycerol is a versatile molecule with many potential applications in fermentation processes and synthetic chemistry. It serves as a glucose substitute in microbial growth media and as a precursor in the synthesis of a number of commercial intermediates or fine chemicals. Chlorinated derivatives of Glycerol are an important class of such chemicals. The main focus of this review is the conversion of Glycerol to chlorinated derivatives, such as epichlorohydrin and chlorohydrins, and their further use in the synthesis of additional downstream products. Downstream products include non-cyclic compounds with allyl, nitrile, azide and other functional groups, as well as oxazolidinones and triazoles, which are cyclic compounds derived from ephichlorohydrin and chlorohydrins. The polymers and ionic liquids, which use Glycerol as an initial building block, are highlighted, as well.
Glycerol. Biochemistry, pharmacokinetics and clinical and practical applications
Sports Med 1998 Sep;26(3):145-67.PMID:9802172DOI:10.2165/00007256-199826030-00002.
Glycerol is a naturally occurring 3-carbon alcohol in the human body. It is the structural backbone of triacylglycerol molecules, and can also be converted to a glycolytic substrate for subsequent metabolism. Serum Glycerol concentrations approximate 0.05 mmol/L at rest, and can increase to 0.30 mmol/L during increased lipolysis associated with prolonged exercise or caloric restriction. When Glycerol is ingested or infused at doses greater than 1.0 g/kg bodyweight, serum concentrations can increase to approximately 20 mmol/L, resulting in more than a 10 mOsmol/kg increase in serum osmolality. Glycerol infusion and ingestion have been used in research settings for almost 60 years, with widespread clinical use between 1961 and 1980 in the treatment of cerebral oedema resulting from acute ischaemic stroke, intraocular hypertension (glaucoma), intracranial hypertension, postural syncope and improved rehydration during acute gastrointestinal disease. Since 1987, Glycerol ingestion with added fluid has been used to increase total body water (Glycerol hyperhydration) by up to 700 ml, thereby providing benefits of improved thermoregulation and endurance during exercise or exposure to hot environments. Despite the small number of studies on Glycerol hyperhydration and exercise, it appears to be an effective method of improving tolerance to exercise and other heat-related stressors.
Potential application of Glycerol in the production of plant beneficial microorganisms
J Ind Microbiol Biotechnol 2017 May;44(4-5):735-743.PMID:27514665DOI:10.1007/s10295-016-1810-2.
This review highlights the importance of research for development of biofertilizer and biocontrol products based on the use of Glycerol for further process scale-up to industrial microbiology. Glycerol can be used successfully in all stages of production of plant beneficial microorganisms. It serves as an excellent substrate in both submerged and solid-state fermentation processes with free and immobilized microbial cells. Glycerol is also one of the most attractive formulation agents that ensures high cell density and viability including in harsh environmental conditions. Future research is discussed to make this inexpensive material a base for industrial production of plant beneficial microorganisms.
Meta-analysis: Effects of Glycerol administration on plasma volume, haemoglobin, and haematocrit
Drug Test Anal 2013 Nov-Dec;5(11-12):896-9.PMID:24353192DOI:10.1002/dta.1580.
The use of Glycerol in combination with excess fluid can be used to increase total body water. Because Glycerol hyperhydration may also be misused to mask the effects of blood doping on doping-relevant parameters, namely haemoglobin and haematocrit, Glycerol has been prohibited by the World Anti-Doping Agency since 2010. In order to test this rationale, the purpose of this meta-analysis was to quantify the effects of Glycerol hyperhydration on plasma volume, haemoglobin, and haematocrit in comparison to administration of fluid only. Following a literature search, a total of seven studies was included and meta-analyses were performed separately for the effects on plasma volume (5 studies, total n = 54) and on haemoglobin (6 studies, n = 52) and haematocrit (6 studies, n = 52). The meta-analysis revealed that the increase in plasma volume was 3.3% larger (95%-CI: 1.1-5.5%) after Glycerol administration when compared to fluid only. Reductions in haemoglobin were 0.2 g/dl (95%-CI: -0.3, 0.0) larger and there was no difference in the changes in haematocrit between Glycerol and fluid administration (95%-CI: -0.7-0.8%). In comparison with other plasma-volume expanding agents, Glycerol hyperhydration has a very limited potential in increasing plasma volume and altering doping-relevant blood parameters.
Lipase-Catalyzed Synthesis and Characterization of Poly(Glycerol sebacate)
Biomacromolecules 2022 Jan 10;23(1):398-408.PMID:34936341DOI:10.1021/acs.biomac.1c01351.
This study demonstrated that immobilized Candida antarctica lipase B (N435) catalysis in bulk leads to higher molecular weight poly(Glycerol sebacate), PGS, than self-catalyzed condensation polymerization. Since the glass-transition temperature, fragility, modulus, and strength for rubbery networks are inversely dependent on the concentration of chain ends, higher molecular weight PGS prepolymers will enable the preparation of cross-linked PGS matrices with unique mechanical properties. The evolution of molecular species during the prepolymerization step conducted at 120 °C for 24 h, prior to enzyme addition, revealed regular decreases in sebacic acid and glycerol-sebacate dimer with corresponding increases in oligomers with chain lengths from 3 to 7 units such that a homogeneous liquid substrate has resulted. At 67 h, for N435-catalyzed PGS synthesis, the carboxylic acid conversion reached 82% without formation of a gel fraction, and number-average molecular weight (Mn) and weight-average molecular weight (Mw) values reached 6000 and 59 400 g/mol, respectively. In contrast, self-catalyzed PGS condensation polymerizations required termination at 55 h to avoid gelation, reached 72% conversion, and Mn and Mw values of 2600 and 13 800 g/mol, respectively. We also report the extent that solvent fractionation can enrich PGS in higher molecular weight chains. The use of methanol as a nonsolvent increased Mn and Mw by 131.7 and 18.3%, respectively, and narrower dispersity (Đ) decreased by 47.7% relative to the nonfractionated product.