Growth Factor is a protein molecule made by the body; it functions to regulate cell division & cell survival. Growth factors can also be produced by genetic engineering in the laboratory and used in biological therapy.
Growth factors bind to receptors on the cell surface, with the result of activating cellular proliferation and/or differentiation. Growth factors are quite versatile, stimulating cellular division in numerous different cell types; while others are specific to a particular cell-type. Growth factors are proteins that promote cell growth.
Growth factors are proteins that function as growth stimulators (mitogens) and/or growth inhibitors, stimulate cell migration, act as chemotactic agents, inhibit cell migration, inhibit invasion of tumor cells, modulate differentiated functions of cells, involved in apoptosis, involved in angiogenesis and promote survival of cells without influencing growth and differentiation.
Growth factors secret diffusible factors that are identified in the conditioned medium of cell cultures. Growth factors are present in membrane-anchored forms. Growth factors act in an autocrine, paracrine, juxtacrine or retrocrine manner.
Usually researchers use the term growth factors as a synonym for cytokines.
Examples for Growth Factors are EGF, FGF, NGF, PDGF, VEGF, IGF, GMCSF, GCSF, TGF, Erythropieitn, TPO, BMP, HGF, GDF, Neurotrophins, MSF, SGF, GDF and more.
Hematopoietic growth factors are hormone-like substances that stimulate bone marrow to produce blood cells. Shortages of blood cells cause most of the symptoms in people with MDS, the use of growth factors is very appealing. Studies have tested several growth factors in patients with MDS, such as granulocyte colony stimulating factor (G-CSF) and granulocyte macrophage-colony stimulating factor (GM-CSF).
Erythropoietin is a growth factor which promotes red blood cell production. Recently it has been found that combining erythropoietin with G-CSF improves the response to the erythropoietin. Interleukin-11 (IL-11) stimulates platelet production after chemotherapy. Current studies try to find the best way to predict which growth factors will treat new diseases and the best way to combine growth factors with each other and with other treatments, such as chemotherapy or hormones.
Growth factors produce extra stem cells before a stem cell harvest. Chemotherapy kills off healthy white blood cells, as well as the leukaemic ones, therefore there is risk of infection while white cell count is low. Low level of white cells is called ‘neutropenia’. Early research of growth factors shown that, while growth factors help the white cell count to recover, they actually don’t make much difference to the number of infections.
Growth Factors are biologically active poly-peptides which function as hormone like regulatory signals, controlling the growth and differentiation of responsive cells. The distinction between growth factors and hormones is frequently arbitrary.
The sequence of amino acids permits growth factors to be placed into families, suggesting that they evolved from a single ancestral protein. The insulin family comprises somatemedins A and C, insulin, insulinlike growth factor (IGF), and multiplication-stimulating factor (MSF). A 2nd family consists of sarcoma growth factor (SGF), transforming growth factors (TGFs), and epidermal growth factor (EGF). In addition, there are growth factors, such as nerve growth factor (NGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF), for which structural homologs have not been identified.
Stimulation of cell proliferation growth factors is similar to the rapid cell proliferation characteristic of tumor cells. Growth factor receptors are similar to the tumor-causing proteins produced by several RNA tumor viruses. Platelet-derived growth factor ( PDGF) is virtually identical to the tumor-causing protein of the RNA tumor virus, simian sarcoma virus.
Growth Factors are involved in cell differentiation and are essential to normal cell cycle, and are thus vital elements in the life of animals from conception to death. Growth Factors mediate fetal development, play a role in maintenance and repair of tissues, stimulate production of blood cells & participate in cancerous processes.
Products for Growth Factors
- Fibroblast Growth Factor(56)
- Growth Hormone(29)
- Hepatocyte Growth Factor(6)
- Insulin-Like Growth Factor(17)
- Keratinocyte Growth Factor(7)
- Macrophage Migration Inhibitory Factor(69)
- Melanoma Inhibitory Activity(3)
- Other Growth Factors(6)
- Placental Growth Factor(10)
- Placental Lactogen(5)
- RANK Ligand(7)
- Retinol Binding Protein(9)
- Stem Cell Factor(5)
- Transforming Growth Factor(14)
- Cat.No. 产品名称 Information
- GP26077 SPP1 Mouse SPP1 Mouse Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 287 amino acids (17-294 a
- GP26076 SPP1 Human, Active SPP1 Human Recombinant produced in E
- GP26075 RBP4 Mouse RBP4 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 191 amino acids (19-201 a
- GP26074 RBP3 Human RBP3 Human Recombinant (321-630a
- GP26073 RBP Human, Native Human Retinol Binding Protein Native produced in urine from the patients with renal tubular proteinuria having a molecular mass of approximately 21kD
- GP26068 PLGF Human, HEK PLGF Human Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain (a
- GP26067 PLGF1 Human, 132 a.a. Placental Growth Factor-1 Human Recombinant produced in E
- GP26066 Placental Lactogen Sf9, Human Placental Lactogen Human produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 197 amino acids (27-217 aa) and having a molecular mass of 23
- GP26065 PDGF-BB Equine PDGF-BB Equine Recombinant produced in E
- GP26061 MCSF Mouse, Sf9 MCSF Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 164 amino acids (33-187 aa) and having a molecular mass of 19
- GP26059 ProInsulin Human ProInsulin C-Peptide Analogue Human Recombinant produced in E
- GP26037 IGFBP4 Sf9, Human Insulin Like Growth Factor Binding Protein-4 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 237 amino acids and having a molecular mass of 30kDa
- GP26036 IGF2 Mouse IGF2 Mouse Recombinant produced in E
- GP26033 IFNAR1 Human IFNAR1 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 415 amino acids (28-436a
- GP26030 HGF Mouse HGF Mouse Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 1146 amino acids (25-931aa) and having a molecular mass of 127
- GP26029 GMCSF Poricne, His GMCSF Poricne Recombinant produced in E
- GP26028 GHBP Human, Sf9 GHBP Human produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 254 amino acids (19-264aa) and having a molecular mass of 29
- GP26027 GCSF Monkey Granulocyte Colony Stimulating Rhesus Macaque Recombinant produced in E
- GP26025 LGALS3 Mouse, Active LGALS3 Mouse Recombinant produced in E
- GP26024 LGALS2 Mouse, Active LGALS2 Mouse Recombinant produced in E
- GP26023 FGF19 Human, HEK FGF19 Mouse Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain (a
- GP26022 FGF17 Mouse Fibroblast Growth Factor 17 Mouse Recombinant produced in E
- GP26021 FGF2 (147), Bovine Fibroblast Growth Factor-basic (147 a
- GP26020 FGF1 Human, 154 a.a. Fibroblast Growth Factor-acidic Human Recombinant produced in E
- GP26018 EPO Rat EPO Rat Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain (27-192 a
- GP26017 EPO Mouse EPO Mouse Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 176 amino acids (27-192 aa) and having a molecular mass of 19
- GP26015 EGF (1-51), Human Epidermal Growth Factor (1-51 a
- GP26013 CTGF Mouse CTGF Mouse Recombinant is a single, glycosylated polypeptide chain containing 329 amino acids (26-348a
- GP26012 CTGF Human (183-255) CTGF Human Recombinant is a single, glycosylated polypeptide chain containing 80 amino acids (183-255a
- GP26002 ACVR1 Human ACVR1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 342 amino acids (21-123a
- GC65588 GB1211
- GC48920 β-Carboline-1-carboxylic Acid An alkaloid with diverse biological activities
- GC48839 Nifuroxazide-d4 An internal standard for the quantification of nifuroxazide
- GC48788 Norethindrone-d6 An internal standard for the quantification of norethindrone
- GC48659 Umbelliprenin A prenylated coumarin with diverse biological activities
- GC48486 AAA A GPR75 antagonist
- GC48479 Migrastatin A fungal metabolite with antimuscarinic and anticancer activities
- GC48433 BX-320 An inhibitor of PDK1
- GC48387 Inostamycin A A bacterial metabolite with anticancer activity
- GC47973 PRGL493 An ACSL4 inhibitor
- GC47963 Plerixafor-d4 An internal standard for the quantification of plerixafor
- GC47955 Phloroglucinol A phenol with diverse biological activities
- GC47720 N,N'-bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine A microbial metabolite with anticancer activity
- GC47582 Lupulone A beta-acid
- GC47459 Irinotecan-d10 (hydrochloride) An internal standard for the quantification of irinotecan
- GC47400 GGTI 2133 (trifluoroacetate salt) A geranylgeranyl transferase I inhibitor
- GC47398 Genistein-d4 An internal standard for the quantification of genistein
- GC47098 CL2-SN-38 (dichloroacetic acid salt) An antibody-drug conjugate containing SN-38
- GC46821 Ajoene A disulfide with antitumor and antiplatelet activities
- GC46733 7,12-Dimethylbenz[a]anthracene A carcinogenic PAH