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Growth Factors(生长因子)

Growth Factor is a protein molecule made by the body; it functions to regulate cell division & cell survival. Growth factors can also be produced by genetic engineering in the laboratory and used in biological therapy.

Growth factors bind to receptors on the cell surface, with the result of activating cellular proliferation and/or differentiation. Growth factors are quite versatile, stimulating cellular division in numerous different cell types; while others are specific to a particular cell-type. Growth factors are proteins that promote cell growth.

Growth factors are proteins that function as growth stimulators (mitogens) and/or growth inhibitors, stimulate cell migration, act as chemotactic agents, inhibit cell migration, inhibit invasion of tumor cells, modulate differentiated functions of cells, involved in apoptosis, involved in angiogenesis and promote survival of cells without influencing growth and differentiation.

Growth factors secret diffusible factors that are identified in the conditioned medium of cell cultures. Growth factors are present in membrane-anchored forms. Growth factors act in an autocrine, paracrine, juxtacrine or retrocrine manner.

Usually researchers use the term growth factors as a synonym for cytokines.

Examples for Growth Factors are EGF, FGF, NGF, PDGF, VEGF, IGF, GMCSF, GCSF, TGF, Erythropieitn, TPO, BMP, HGF, GDF, Neurotrophins, MSF, SGF, GDF and more.

Hematopoietic growth factors are hormone-like substances that stimulate bone marrow to produce blood cells. Shortages of blood cells cause most of the symptoms in people with MDS, the use of growth factors is very appealing. Studies have tested several growth factors in patients with MDS, such as granulocyte colony stimulating factor (G-CSF) and granulocyte macrophage-colony stimulating factor (GM-CSF).

Erythropoietin is a growth factor which promotes red blood cell production. Recently it has been found that combining erythropoietin with G-CSF improves the response to the erythropoietin. Interleukin-11 (IL-11) stimulates platelet production after chemotherapy. Current studies try to find the best way to predict which growth factors will treat new diseases and the best way to combine growth factors with each other and with other treatments, such as chemotherapy or hormones.

Growth factors produce extra stem cells before a stem cell harvest. Chemotherapy kills off healthy white blood cells, as well as the leukaemic ones, therefore there is risk of infection while white cell count is low. Low level of white cells is called ‘neutropenia’. Early research of growth factors shown that, while growth factors help the white cell count to recover, they actually don’t make much difference to the number of infections.

Growth Factors are biologically active poly-peptides which function as hormone like regulatory signals, controlling the growth and differentiation of responsive cells. The distinction between growth factors and hormones is frequently arbitrary.

The sequence of amino acids permits growth factors to be placed into families, suggesting that they evolved from a single ancestral protein. The insulin family comprises somatemedins A and C, insulin, insulinlike growth factor (IGF), and multiplication-stimulating factor (MSF). A 2nd family consists of sarcoma growth factor (SGF), transforming growth factors (TGFs), and epidermal growth factor (EGF). In addition, there are growth factors, such as nerve growth factor (NGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF), for which structural homologs have not been identified.

Stimulation of cell proliferation growth factors is similar to the rapid cell proliferation characteristic of tumor cells. Growth factor receptors are similar to the tumor-causing proteins produced by several RNA tumor viruses. Platelet-derived growth factor ( PDGF) is virtually identical to the tumor-causing protein of the RNA tumor virus, simian sarcoma virus.

Growth Factors are involved in cell differentiation and are essential to normal cell cycle, and are thus vital elements in the life of animals from conception to death. Growth Factors mediate fetal development, play a role in maintenance and repair of tissues, stimulate production of blood cells & participate in cancerous processes.

Products for  Growth Factors

  1. Cat.No. 产品名称 Information
  2. GC65588 GB1211 GB1211 是一种具有口服活性的 galectin-3 (Gal-3) 抑制剂。
  3. GC48920 β-Carboline-1-carboxylic Acid An alkaloid with diverse biological activities
  4. GC48839 Nifuroxazide-d4 An internal standard for the quantification of nifuroxazide
  5. GC48788 Norethindrone-d6 An internal standard for the quantification of norethindrone
  6. GC48659 Umbelliprenin A prenylated coumarin with diverse biological activities
  7. GC48486 AAA A GPR75 antagonist
  8. GC48479 Migrastatin A fungal metabolite with antimuscarinic and anticancer activities
  9. GC48433 BX-320 BX-320 是一种选择性的、ATP 竞争性的、口服活性的直接 PDK1 抑制剂,在直接激酶测定中其 IC50 为 30 nM。 BX-320 还诱导细胞凋亡。抗癌作用。
  10. GC48387 Inostamycin A A bacterial metabolite with anticancer activity
  11. GC47973 PRGL493 PRGL493 是一种有效的选择性长链酰基辅酶A 合成酶 4 (ACSL4) 抑制剂。 PRGL493 阻断乳腺和前列腺细胞和动物模型中的细胞增殖和肿瘤生长。 PRGL493 用于癌症研究。
  12. GC47963 Plerixafor-d4 An internal standard for the quantification of plerixafor
  13. GC47955 Phloroglucinol A phenol with diverse biological activities
  14. GC47720 N,N'-bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine A microbial metabolite with anticancer activity
  15. GC47582 Lupulone Lupulone 是一种来自啤酒花植物 H 的 β-酸。
  16. GC47459 Irinotecan-d10 (hydrochloride) Irinotecan-d10 ((+)-Irinotecan-d10) hydrochloride 是氘标记的 Irinotecan。 Irinotecan ((+)-Irinotecan) 是一种拓扑异构酶 I 抑制剂,通过与拓扑异构酶 I-DNA 复合物结合来阻止 DNA 链的再连接。
  17. GC47400 GGTI 2133 (trifluoroacetate salt) A geranylgeranyl transferase I inhibitor
  18. GC47398 Genistein-d4 Genistein-d4 (NPI 031L-d4) 是氘标记的 Genistein。染料木黄酮是一种大豆异黄酮,是一种多种酪氨酸激酶(例如 EGFR)抑制剂,主要通过改变细胞凋亡、细胞周期和血管生成以及抑制转移来作为针对不同类型癌症的化学治疗剂。
  19. GC47098 CL2-SN-38 (dichloroacetic acid salt) An antibody-drug conjugate containing SN-38
  20. GC46821 Ajoene Ajoene 是一种大蒜衍生的化合物,是一种抗血栓和抗真菌剂。
  21. GC46733 7,12-Dimethylbenz[a]anthracene 7,12-二甲基苯并[a]蒽作为多环芳烃 (PAH) 具有致癌活性。 7,12-二甲基苯并[a]蒽用于在各种啮齿动物模型中诱导肿瘤形成。
  22. GC46018 Norstictic Acid Norstic acid 是一种有效的选择性变构转录调节剂。
  23. GC46015 KY 05009 KY 05009 是一种 ATP 竞争性 Traf2 和 Nck 相互作用激酶 (TNIK) 抑制剂,Ki 为 100 nM。 KY 05009 药理学抑制人肺腺癌细胞中 TGF-β1 诱导的上皮间质转化 (EMT)。 KY 05009 抑制 TNIK 的蛋白质表达和 Wnt 靶基因的转录活性,并诱导癌细胞凋亡。 KY 05009 具有抗癌活性。
  24. GC45777 Peonidin 3-O-glucoside (chloride) Peonidin 3-O-glucoside (chloride) 是一种花青素,可作为胰岛素促分泌剂。
  25. GC45769 Vandetanib-d6 Vandetanib-d6 (ZD6474-d6) 是氘标记的 Vandetanib。 Vandetanib (D6474) 是一种有效的口服活性 VEGFR2/KDR 酪氨酸激酶活性抑制剂 (IC50=40 nM)。 Vandetanib 对 VEGFR3/FLT4 (IC50=110 nM) 和 EGFR/HER1 (IC50=500 nM) 的酪氨酸激酶活性也有活性。
  26. GC45767 Dovitinib-d8 Dovitinib-D8 (CHIR-258-D8) 是氘标记的 Dovitinib。 Dovitinib (CHIR-258) 是一种多靶点酪氨酸激酶抑制剂,对 FLT3、c-Kit、FGFR1/FGFR3、VEGFR1/VEGFR2/ 的 IC50 为 1、2、8/9、10/13/8、27/210 nM VEGFR3 和 PDGFRα/PDGFRβ,分别。
  27. GC45760 Nilutamide-d6 Nilutamide-d6 (Nilandron-d6) 是氘标记的 Nilutamide。尼鲁米特(Nilandron)是在转移性前列腺癌研究中提出的一种非甾体抗雄激素药物。
  28. GC45554 Questiomycin A  
  29. GC45448 Epitalon (acetate)  
  30. GC45403 CAY10735  
  31. GC45270 (±)10(11)-EDP Ethanolamide (±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively).
  32. GC45266 (+)-Macrosphelide A (+)-Macrosphelide A 是一种大环内酯类抗生素。
  33. GC45040 Thiodigalactoside 硫代半乳糖苷 (TDG) 是一种口服有效的半乳凝素 (GAL) 抑制剂,对 GAL1 和 GAL3 的 Kd 值分别为 24 μM 和 49 μM 。
  34. GC44847 RKI-1313 RKI-1313 是一种 ROCK 抑制剂,对 ROCK 1 和 ROCK 2 的 IC50 分别为 34、8 μM。 RKI-1313 对 ROCK 底物的磷酸化水平、迁移、侵袭或不依赖锚定的生长几乎没有影响。
  35. GC44782 PX-866-17OH A PI3K inhibitor
  36. GC44545 Palmitoleoyl 3-carbacyclic Phosphatidic Acid Cyclic phosphatidic acids (cPAs) are naturally occurring analogs of lysophosphatidic acid (LPA) in which the sn-2 hydroxy group forms a 5-membered ring with the sn-3 phosphate.
  37. GC44518 Osteocalcin (1-49) (human) (trifluoroacetate salt) Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone.
  38. GC44387 Neurotensin (trifluoroacetate salt) Neurotensin is a neuropeptide that is distributed throughout the CNS and in enteroendocrine cells of the small intestine that has diverse biological activities.
  39. GC44313 Naphthofluorescein Naphthofluorescein 抑制 HIF-1 和 Mint3 之间的相互作用。Naphthofluorescein 抑制 Mint3 依赖性 HIF-1 活性和癌细胞和巨噬细胞的糖酵解,在体外没有细胞毒性,在体内没有副作用。 Naphthofluorescein 也是一种荧光 pH 敏感探针,可用于功能性切伦科夫成像。
  40. GC44223 ML-299 ML-299 是一种选择性变构调节剂和磷脂酶 D1 和 D2 的双重抑制剂(IC50 值分别为 6 和 12 nM)。 ML-299 减少 U87-MG 胶质母细胞瘤细胞的侵袭性迁移。
  41. GC44222 ML-298 ML298 是一种有效的选择性磷脂酶 D2 (PLD2) 抑制剂,IC50 为 355 nM。 ML298 减少 U87-MG 胶质母细胞瘤细胞的侵袭性迁移。
  42. GC43780 GM 1489 GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively.
  43. GC43732 Ganglioside GM3 Mixture (sodium salt) Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.
  44. GC43729 Ganglioside GD3 Mixture (sodium salt) Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases.
  45. GC43727 Ganglioside GD1a mixture (sodium salt)

    Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver.

  46. GC43719 Fusarisetin A Fusarisetin A 是一种五环真菌代谢物,是一种腺泡形态发生抑制剂。
  47. GC43361 Cytostatin (sodium salt) Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice.
  48. GC43360 Cytostatin Cytostatin 是一种有效的选择性 PP2A 抑制剂,具有良好的抗肿瘤活性。 Cytostatin 也是细胞粘附到细胞外基质的抑制剂并诱导细胞凋亡。 Cytostatin 属于 fostriecin 家族的天然产物。
  49. GC43346 Cyclopamine-KAAD Cyclopamine-KAAD 是一种刺猬信号抑制剂,是一种平滑拮抗剂。
  50. GC43042 C17 Lactosylceramide (d18:1/17:0) C17 Lactosylceramide is a naturally occurring sphingolipid that has been found in human brain metastases of lung adenocarcinomas but not in healthy brain tissue.
  51. GC42975 BRD32048 BRD32048 是 ETV1 的直接结合剂,KD 为 17.1 μM。 BRD32048 调节 ETV1 介导的转录活性和 ETV1 驱动的癌细胞的侵袭。 BRD32048 抑制 ETV1 乙酰化并促进其降解。 BRD32048 是最佳候选 ETV1 干扰素。

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