Growth Factors(生长因子)
Growth Factor is a protein molecule made by the body; it functions to regulate cell division & cell survival. Growth factors can also be produced by genetic engineering in the laboratory and used in biological therapy.
Growth factors bind to receptors on the cell surface, with the result of activating cellular proliferation and/or differentiation. Growth factors are quite versatile, stimulating cellular division in numerous different cell types; while others are specific to a particular cell-type. Growth factors are proteins that promote cell growth.
Growth factors are proteins that function as growth stimulators (mitogens) and/or growth inhibitors, stimulate cell migration, act as chemotactic agents, inhibit cell migration, inhibit invasion of tumor cells, modulate differentiated functions of cells, involved in apoptosis, involved in angiogenesis and promote survival of cells without influencing growth and differentiation.
Growth factors secret diffusible factors that are identified in the conditioned medium of cell cultures. Growth factors are present in membrane-anchored forms. Growth factors act in an autocrine, paracrine, juxtacrine or retrocrine manner.
Usually researchers use the term growth factors as a synonym for cytokines.
Examples for Growth Factors are EGF, FGF, NGF, PDGF, VEGF, IGF, GMCSF, GCSF, TGF, Erythropieitn, TPO, BMP, HGF, GDF, Neurotrophins, MSF, SGF, GDF and more.
Hematopoietic growth factors are hormone-like substances that stimulate bone marrow to produce blood cells. Shortages of blood cells cause most of the symptoms in people with MDS, the use of growth factors is very appealing. Studies have tested several growth factors in patients with MDS, such as granulocyte colony stimulating factor (G-CSF) and granulocyte macrophage-colony stimulating factor (GM-CSF).
Erythropoietin is a growth factor which promotes red blood cell production. Recently it has been found that combining erythropoietin with G-CSF improves the response to the erythropoietin. Interleukin-11 (IL-11) stimulates platelet production after chemotherapy. Current studies try to find the best way to predict which growth factors will treat new diseases and the best way to combine growth factors with each other and with other treatments, such as chemotherapy or hormones.
Growth factors produce extra stem cells before a stem cell harvest. Chemotherapy kills off healthy white blood cells, as well as the leukaemic ones, therefore there is risk of infection while white cell count is low. Low level of white cells is called ‘neutropenia’. Early research of growth factors shown that, while growth factors help the white cell count to recover, they actually don’t make much difference to the number of infections.
Growth Factors are biologically active poly-peptides which function as hormone like regulatory signals, controlling the growth and differentiation of responsive cells. The distinction between growth factors and hormones is frequently arbitrary.
The sequence of amino acids permits growth factors to be placed into families, suggesting that they evolved from a single ancestral protein. The insulin family comprises somatemedins A and C, insulin, insulinlike growth factor (IGF), and multiplication-stimulating factor (MSF). A 2nd family consists of sarcoma growth factor (SGF), transforming growth factors (TGFs), and epidermal growth factor (EGF). In addition, there are growth factors, such as nerve growth factor (NGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF), for which structural homologs have not been identified.
Stimulation of cell proliferation growth factors is similar to the rapid cell proliferation characteristic of tumor cells. Growth factor receptors are similar to the tumor-causing proteins produced by several RNA tumor viruses. Platelet-derived growth factor ( PDGF) is virtually identical to the tumor-causing protein of the RNA tumor virus, simian sarcoma virus.
Growth Factors are involved in cell differentiation and are essential to normal cell cycle, and are thus vital elements in the life of animals from conception to death. Growth Factors mediate fetal development, play a role in maintenance and repair of tissues, stimulate production of blood cells & participate in cancerous processes.
Products for Growth Factors
- Activin(12)
- CSF(31)
- CTGF(6)
- EGF(19)
- Epigen(3)
- Erythropoietin(9)
- Fibroblast Growth Factor(59)
- Galectin(26)
- Growth Hormone(29)
- HDGF(3)
- Hepatocyte Growth Factor(8)
- IGFBP(11)
- Insulin(6)
- Insulin-Like Growth Factor(17)
- Keratinocyte Growth Factor(7)
- Leptin(31)
- Macrophage Migration Inhibitory Factor(69)
- Melanoma Inhibitory Activity(3)
- Myostatin(5)
- Noggin(3)
- NOV(3)
- Omentin(3)
- Oncostatin-M(6)
- Osteopontin(4)
- Osteoprotegerin(6)
- Other Growth Factors(6)
- PDGF(16)
- Periostin(2)
- Placental Growth Factor(10)
- Placental Lactogen(5)
- RANK Ligand(7)
- Prolactin(21)
- Retinol Binding Protein(9)
- Stem Cell Factor(5)
- Transforming Growth Factor(16)
- VEGF(27)
- Cat.No. 产品名称 Information
- GC46733 7,12-Dimethylbenz[a]anthracene A carcinogenic PAH
- GC46018 Norstictic Acid A lichen metabolite
- GC46015 KY 05009 A TNIK inhibitor
- GC45777 Peonidin 3-O-glucoside (chloride) An anthocyanin with diverse biological activities
- GC45769 Vandetanib-d6 An internal standard for the quantification of vandetanib
- GC45767 Dovitinib-d8 An internal standard for the quantification of dovitinib
- GC45760 Nilutamide-d6 An internal standard for the quantification of nilutamide
- GC45554 Questiomycin A A phenoxazine and chromophore with antibacterial and anticancer activities
- GC45448 Epitalon (acetate) A synthetic tetrapeptide with anti-aging properties
- GC45403 CAY10735 An anticancer compound
- GC45270 (±)10(11)-EDP Ethanolamide An ω-3 endocannabinoid epoxide and CB receptor agonist
- GC45266 (+)-Macrosphelide A A fungal metabolite
- GC45040 Thiodigalactoside A galectin-binding diglycan
- GC44847 RKI-1313 A ROCK1 and ROCK2 inhibitor
- GC44782 PX-866-17OH A PI3K inhibitor
- GC44545 Palmitoleoyl 3-carbacyclic Phosphatidic Acid Inhibitor of autotaxin
- GC44518 Osteocalcin (1-49) (human) (trifluoroacetate salt) A bone peptide
- GC44387 Neurotensin (trifluoroacetate salt) A neuropeptide with diverse biological activities
- GC44313 Naphthofluorescein Inhibitor of furin
- GC44223 ML-299 Dual inhibitor of PLD1 and PLD2
- GC44222 ML-298 A selective inhibitor of PLD2
- GC43780 GM 1489 An MMP inhibitor
- GC43732 Ganglioside GM3 Mixture (sodium salt) A mixture of ganglioside GM3
- GC43729 Ganglioside GD3 Mixture (sodium salt) A mixture of ganglioside GD3
- GC43727 Ganglioside GD1a mixture (sodium salt) A mixture of ganglioside GD1a
- GC43719 Fusarisetin A An inhibitor of acinar morphogenesis
- GC43361 Cytostatin (sodium salt) A selective PP2A inhibitor
- GC43360 Cytostatin A selective PP2A inhibitor
- GC43346 Cyclopamine-KAAD A potent inhibitor of hedgehog signaling
- GC43042 C17 Lactosylceramide (d18:1/17:0) A naturally occurring sphingolipid
- GC42975 BRD32048 An inhibitor of the ETV1 transcription factor oncoprotein
- GC42951 BMP-22 An inhibitor of autotaxin
- GC41655 (±)19(20)-EDP Ethanolamide An ω-3 endocannabinoid epoxide and CB receptor agonist
- GC41653 (±)16(17)-DiHDPA An epoxygenase metabolite of DHA
- GC41648 (±)13(14)-DiHDPA A metabolite of DHA
- GC41220 13(S)-HODE methyl ester Hydroxy fatty acid methyl ester
- GC40444 (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic Acid A stable isomer of 15(S)-HETE
- GC40285 Rubratoxin A A selective PP2A inhibitor
- GP23813 LGALS10 Human Charcot-Leyden Crystal Protein Human Recombinant
- GP21058 VEGI Human, His Vascular Endothelial Growth InhibitorHuman Recombinant, His Tag
- GP21057 VEGI Human Human Vascular Endothelial Growth Inhibitor Recombinant
- GP21056 VEGF E (Orf Virus) Vascular Endothelial Growth Factor-E Recombinant (Orf Virus)
- GP21055 VEGF D Human Vascular Endothelial Growth Factor D Human Recombinant
- GP21054 VEGF C Rat (152 a.a.) Vascular Endothelial Growth Factor-C (152 a.a) Rat Recombinant
- GP21053 VEGF C Rat Vascular Endothelial Growth Factor Related Protein Rat Recombinant
- GP21052 VEGFC Human, Sf9 Vascular Endothelial Growth Factor C Human Recombinant, Sf9
- GP21051 VEGFC Human HEK Vascular Endothelial Growth Factor C Human Recombinant HEK
- GP21050 VEGF C Human Vascular Endothelial Growth Factor C Human Recombinant
- GP21049 VEGF Rat, His Vascular Endothelial Growth Factor Rat Recombinant, His Tag
- GP21048 VEGF Rat 血管内皮生长因子大鼠重组