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Home >> Signaling Pathways >> Proteases >> Endogenous Metabolite

Endogenous Metabolite(内源性代谢物)

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Products for  Endogenous Metabolite

  1. Cat.No. 产品名称 Information
  2. GC61164 Oxytetracycline hydrochloride

    盐酸土霉素

     A broad-spectrum antibiotic
  3. GC61150 O-Desmethylangolensin

    O-DMA

     A phytoestrogen and an active metabolite of diadzein
  4. GC61145 Octadecanedioic acid

    十八烷二酸

     Octadecanedioicacid是一种内源性代谢物，一种长链二羧酸，曾在雷氏综合征的血清游离脂肪酸中被发现。
  5. GC61144 Octadecanal

    十八烷醛

     Octadecanal是一种长链醛，存在于大腿和胸部肌肉中。
  6. GC61130 NHC-triphosphate

    NHC-triphosphate是NHC的活性胞内磷酸盐代谢物(intracellularmetabolite)，以三磷酸盐的形式存在。NHC-triphosphate是病毒聚合酶(viralpolymerase)的弱底物替代物，会被并入HCV复制子RNA中。
  7. GC61107 N-Acetyl-L-glutamic acid

    N-乙酰-L-谷氨酸

     N-Acetylglutamic acid (N-Acetylglutamate) is the first intermediate involved in the biosynthesis of arginine in prokaryotes and simple eukaryotes and a regulator in the process known as the urea cycle that converts toxic ammonia to urea for excretion from the body in vertebrates.
  8. GC61105 N4-Acetylcytidine

    N4-乙酰基胞苷

     A catabolite of cytidine
  9. GC61103 N,N,O-Tridesmethylvenlafaxine

    1-2-氨基-1-(4-羟苯基)乙基环己醇

     N,N,O-Tridesmethylvenlafaxine是一种内源性代谢产物。
  10. GC61083 Monomethyl phthalate

    邻苯二甲酸单甲酯,2-(Methoxycarbonyl)benzoic acid

     Monomethylphthalate是一种邻苯二甲酸代谢物(metabolite)。Monomethylphthalate作为暴露于phthalate后的尿液生物标记物，可作为甲状腺癌和良性结节的检测指标。
  11. GC61081 Monobenzyl phthalate

    邻苯二甲酸单苄酯,2-((Benzyloxy)carbonyl)benzoic acid

     Monobenzylphthalate(2-((Benzyloxy)carbonyl)benzoicacid)是暴露于邻苯二甲酸盐(如，邻苯二甲酸二乙基己酯)后的尿代谢物(urinarymetabolite)。
  12. GC61057 Methyl p-tert-butylphenylacetate

    对叔丁基苯乙酸甲酯

     Methyl 4-tert-butylphenylacetate is a flavouring ingredient with a roasted, chocolate-like flavour.
  13. GC61056 Methyl phenylacetate

    苯乙酸甲酯

     Methylphenylacetate是一种内源性代谢产物。
  14. GC61053 Methyl cyclohexanecarboxylate

    环己甲酸甲酯

     An aliphatic ester
  15. GC61051 Methyl anisate

    4-甲氧基苯甲酸甲酯

     Methylanisate是一种内源性代谢产物。
  16. GC61050 Methyl acetylacetate

    乙酰乙酸甲酯,Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl 3-oxobutyrate; Methyl acetoacetate; Methyl acetylacetate

     Methyl acetylacetate (MAA, Acetoacetate methyl ester, Methyl 3-oxobutanoate, Methyl 3-oxobutyrate, Methyl acetoacetate, Methyl acetylacetate), an endogenous metabolite, is used as a chemical reagent used in the synthesis of pharmaceuticals.
  17. GC61049 Methyl 3-phenylpropanoate

    3-苯丙酸甲酯

     Methyl3-phenylpropanoate是一种内源性代谢产物。
  18. GC61048 Methoxyacetic acid

    甲氧基乙酸

     Methoxyaceticacid是一种内源性代谢产物。
  19. GC61044 Mesitaldehyde

    2,4,6-三甲基苯甲醛; 2,4,6-Trimethylbenzaldehyde

     Mesitaldehyde是一种内源性代谢产物。
  20. GC61027 m-Anisaldehyde

    3-甲氧基苯甲醛

     m-Anisaldehyde是一种内源性代谢产物。
  21. GC61013 Lumisterol 3 (>90%)

    光甾醇 3; 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity C

     A photoisomer of previtamin D3
  22. GC61007 L-Sepiapterin

    L-墨蝶呤,Sepiapterin

     L-Sepiapterin(Sepiapterin)是内皮型一氧化氮合酶(eNOS)辅因子四氢生物喋呤(BH4)的前体。L-Sepiapterin改善db/db小鼠肠系膜小动脉内皮功能障碍，诱导血管生成。L-Sepiapterin通过下调p70S6K依赖性VEGFR-2表达抑制卵巢癌细胞增殖和迁移。
  23. GC60999 L-Norvaline

    L-正缬氨酸

     An inhibitor of arginase and p70S6K1
  24. GC60991 L-Homocysteine

    L-高半胱氨酸

     A thiol-containing amino acid
  25. GC60979 L-Cysteine hydrochloride hydrate

    L-半胱氨酸盐酸盐 一水合物

     L-cysteine Hydrochloride, also known as L-CYSTEINE or Cysteine HCL (anhydrous), is classified as a cysteine or a cysteine derivative that increases glutathione levels and is important for lung and brain function and liver detoxification.
  26. GC60976 L-Aspartic aicd sodium

    L-天门冬氨酸钠; Sodium L-aspartate

     L-Asparticaicdsodium是一种氨基酸，被证明是一种结肠特异性药物输送的前体药物。
  27. GC60948 Isohomovanillic acid

    3-羟基-4-甲氧基苯乙酸,3-Hydroxy-4-methoxyphenylacetic acid; iso-HVA; Homoisovanillic acid

     Isohomovanillic acid is a deaminated metabolite of catecholamines formed by the enzyme catechol-O-methyltransferase which catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine.
  28. GC60942 Isobutyryl-L-carnitine chloride

    L-异丁酰基肉碱

     An acylcarnitine
  29. GC60934 Indole-3-methanamine

    吲哚-3-甲胺

     Indole-3-methanamine是大麦、谷类食物的摄取生物标志物。
  30. GC60933 Imidazol-1-yl-acetic acid

    咪唑-1-乙酸

     Imidazol-1-yl-aceticacid是一种内源性代谢产物。
  31. GC60916 Hydroxyacetone

    丙酮醇

     Hydroxyacetone是一种内源性代谢产物。
  32. GC60898 H-His-OH.HCl.H2O

    L-盐酸组氨酸一水物,H-His-OH.HCl.H2O

     L-Histidine monohydrochloride monohydrate (L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O), a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture.
  33. GC60859 Fructosyl-lysine dihydrochloride

    Ε-N-脱氧果糖赖氨酸二盐酸盐,Fructoselysine dihydrochloride

     Fructosyl-lysine(Fructoselysine)dihydrochloride是葡萄糖与赖氨酸通过美拉德反应生成的一种氨基糖基化产物(amadoriglycation)。Fructosyl-lysine是葡萄糖烷的前体，葡萄糖烷是一种赖氨酸-精氨酸蛋白交联物，可作为糖尿病中检测的指标。
  34. GC60819 Ethoxyacetic acid

    乙氧基乙酸

     Ethoxyaceticacid是一种内源性代谢产物。
  35. GC60793 D-Ribonolactone

    D-核糖内酯

     D-Ribonolactone是一种糖内酯，也是一种大肠杆菌β-半乳糖苷酶(β-galactosidase)的抑制剂，Ki为26mM。
  36. GC60784 DL-Tryptophan

    DL-色氨酸,(±)-Tryptophan

     A racemic mixture of D- and L-tryptophan
  37. GC60780 Diphenyl disulfide

    二苯二硫醚

     Diphenyldisulfide是一种内源性代谢产物。
  38. GC60779 Dimethylmalonic acid

    二甲基丙二酸

     Dimethylmalonicacid是人血清中的短链二羧酸。Dimethylmalonicacid也是在肺泡呼吸中检测到的挥发性有机化合物。
  39. GC60768 Dibenzyl disulfide

    二苄基二硫

     Dibenzyldisulfide是一种内源性代谢产物。
  40. GC60734 Cyclohexaneacetic acid

    环己基乙酸

     Cyclohexaneacetic acid is a flavouring ingredient.
  41. GC60728 Creosol

    2-甲氧基-4-甲基苯酚,2-Methoxy-4-methylphenol

     A phenolic pyrolysis product of plant biomass
  42. GC60720 Coenzyme FO CoenzymeFO是一种脱氮黄素发色团，在产甲烷途径中起着重要的氢化物受体/供体作用。
  43. GC60672 Carveol

    香芹醇

     A monoterpene alcohol with nematocidal activity
  44. GC60640 Benzylideneacetone

    苄叉丙酮,Benzalacetone

     Benzylideneacetone是一种内源性代谢产物。
  45. GC60633 Benzophenone

    二苯甲酮

     Benzophenone (Diphenyl ketone, Benzoylbenzene) filters out both UVA and UVB rays and is widely used in a great variety of sunscreens and personal care products.
  46. GC60574 Allantoic acid

    尿囊酸

     Allantoicacid是尿酸的降解产物，与嘌呤代谢有关。
  47. GC60555 Acetyl phosphate(lithium potassium)

    乙酰磷酸锂钾盐

     乙酰磷酸锂钾（Acetyl phosphate(lithium potassium) ）是一种有机金属化合物，用作磷酰基供体，它常用于蛋白质磷酸化反应。
  48. GC60531 5α-Cholestan-3-one

    5-Α-胆甾烷-3-酮,5α-Cholestanone

     5alpha-Cholestan-3-one (Coprostanone) is a substrate of cholestenone 5alpha-reductase.
  49. GC60529 5-Hydroxy-2'-deoxyuridine

    5-OHdU

     5-Hydroxy-2'-deoxyuridine(5-OHdU)是一种2'-Deoxycytidine的主要稳定氧化产物。5-Hydroxy-2'-deoxyuridine可以通过DNA聚合酶在体外掺入DNA。
  50. GC60525 4-Vinylphenol (10%w/w in propylene glycol)

    4-乙烯基苯酚

    4-Vinylphenol存在于药用草白花蛇舌草，野生稻中，也是葡萄酒中乳酸菌对对香豆酸和阿魏酸的代谢产物。4-Vinylphenol诱导凋亡(apoptosis)，在体内抑制血管形成并抑制浸润性乳腺肿瘤生长。
  51. GC60524 4-Pentenoic acid

    4-戊烯酸

     4-Pentenoic acid (Allylacetic acid, 3-vinylpropionic acid, 4-penten-1-oic acid), a flavouring ingredient, is used to inhibit fatty acid oxidation in rat heart mitochondria.

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